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Recent findings from our studies indicate that basal autophagy is required for the efficient lysosomal catabolism of sialyloligosaccharides, and that the downregulation of sialin, a lysosomal transporter of sialic acids can cause a significant delay in the cytosolic accumulation of such glycans. The findings reported herein show that the sialin protein level was increased when the autophagy process was inhibited. This effect appears to be specific to sialin, since the amount of LAMP1, another lysosomal membrane protein, remains constant under the same conditions. Our results suggest that autophagy may regulate the stability of sialin, and it could lead to the cytosolic accumulation of sialyloligosaccharides in autophagy-defective cells.<\/jats:p>","DOI":"10.1080\/09168451.2014.991682","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T10:44:53Z","timestamp":1418640293000},"page":"553-557","update-policy":"http:\/\/dx.doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["Autophagy regulates the stability of sialin, a lysosomal sialic acid transporter"],"prefix":"10.1080","volume":"79","author":[{"given":"Chengcheng","family":"Huang","sequence":"first","affiliation":[{"name":"Glycometabolome Team, Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, RIKEN Global Research Cluster, Wako, Japan"},{"name":"Graduate School of Science and Engineering, Saitama University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Seino","sequence":"additional","affiliation":[{"name":"Glycometabolome Team, Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, RIKEN Global Research Cluster, Wako, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Glycometabolome Team, Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, RIKEN Global Research Cluster, Wako, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimi","family":"Haga","sequence":"additional","affiliation":[{"name":"Glycometabolome Team, Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, RIKEN Global Research Cluster, Wako, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Glycometabolome Team, Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, RIKEN Global Research Cluster, Wako, Japan"},{"name":"Graduate School of Science and Engineering, Saitama University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2015,4,3]]},"reference":[{"key":"2021033107362770500_CIT0001","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1038\/sj.cdd.4401728","article-title":"The pleiotropic role of autophagy: from protein metabolism to bactericide","volume":"12","author":"Mizushima","year":"2005","journal-title":"Cell Death Differ"},{"key":"2021033107362770500_CIT0002","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"2021033107362770500_CIT0003","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/ncb0910-814","article-title":"Eaten alive: a history of macroautophagy","volume":"12","author":"Yang","year":"2010","journal-title":"Nat. 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