{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:30:35Z","timestamp":1783675835128,"version":"3.55.0"},"reference-count":30,"publisher":"Informa UK Limited","issue":"8","license":[{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We investigated the efficacy of supplementing the diet with pteroylmonoglutamic acid (PGA), choline, or phosphatidylcholine (PC) in ameliorating the lipid accumulation in rat liver that is induced by vitamin B6 (B6) deficiency. In Experiment 1, male Wistar rats were fed a control, B6-deficient, or PGA-, choline-, or PC-supplemented (10 mg, 4 g, and 6.3 g\/kg of diet, respectively) B6-deficient diet containing l-methionine at 9\u00a0g\/kg of diet for 35\u00a0days. In Experiment 2, rats were fed a control, B6-deficient, or PC-supplemented (at 3.15, 6.3, or 12.6\u00a0g PC\/kg of diet) B6-deficient diet for 35\u00a0days. Choline or PC supplementation ameliorated liver lipid deposition and returned plasma lipids to normal. Judging from these results, it appeared that B6 deficiency decreased the synthesis of PC in the liver, thereby decreasing the secretion of very low-density lipoproteins, and in consequence producing lipid accumulation in the liver and reductions of plasma lipids.<\/jats:p>","DOI":"10.1080\/09168451.2015.1020755","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T12:11:24Z","timestamp":1426594284000},"page":"1320-1326","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":14,"title":["Accumulation of lipid in rat liver was induced by vitamin B6 deficiency and was ameliorated by supplemental phosphatidylcholine in the diet"],"prefix":"10.1080","volume":"79","author":[{"given":"Erina","family":"Kitagawa","sequence":"first","affiliation":[{"name":"The United Graduate School of Agricultural Science, Gifu University, Gifu, Japan"},{"name":"Faculty of Health and Human Life, Nagoya Bunri University, Inazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"The Graduate School of Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"The United Graduate School of Agricultural Science, Gifu University, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"The United Graduate School of Agricultural Science, Gifu University, Gifu, Japan"},{"name":"The Graduate School of Applied Biological Sciences, Gifu University, Gifu, Japan"},{"name":"Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"The United Graduate School of Agricultural Science, Gifu University, Gifu, Japan"},{"name":"The Graduate School of Applied Biological Sciences, Gifu University, Gifu, Japan"},{"name":"Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2015,8,3]]},"reference":[{"key":"2021033114264924300_CIT0001","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.1995.03530130055028","article-title":"A quantitative assessment of plasma homocysteine as a risk factor for vascular disease","volume":"274","author":"Boushey","year":"1995","journal-title":"JAMA"},{"key":"2021033114264924300_CIT0002","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","article-title":"Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis","volume":"325","author":"Wald","year":"2002","journal-title":"Br. 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