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Pro-Hyp content in the hapten-treated ear was significantly higher in the chronic phase of contact dermatitis than the vehicle control. In contrast, hydroxyprolylglycine contents remained at lower levels in all cases compared to Pro-Hyp. Four hours after the ingestion of [13C5,15N]Pro and [13C5,15N]Pro-Hyp, labeled-Pro-Hyp and Pro, respectively, appeared only in the ear with dermatitis. Thus, Pro-Hyp is generated and degraded as part of the rapid synthesis and degradation of collagen in the ear with dermatitis. In addition to the endogenously generated Pro-Hyp, the orally administered Pro-Hyp was deposited in the ears.<\/jats:p>","DOI":"10.1080\/09168451.2015.1027653","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T16:54:08Z","timestamp":1428425648000},"page":"1356-1361","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":28,"title":["Detection of endogenous and food-derived collagen dipeptide prolylhydroxyproline (Pro-Hyp) in allergic contact dermatitis-affected mouse ear"],"prefix":"10.1080","volume":"79","author":[{"given":"Masashi","family":"Kusubata","sequence":"first","affiliation":[{"name":"Research Institute of Biomatrix, Nippi Inc., Toride, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoh-ichi","family":"Koyama","sequence":"additional","affiliation":[{"name":"Research Institute of Biomatrix, Nippi Inc., Toride, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisa","family":"Tometsuka","sequence":"additional","affiliation":[{"name":"Research Institute of Biomatrix, Nippi Inc., Toride, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Shigemura","sequence":"additional","affiliation":[{"name":"Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan"},{"name":"Faculty of Domestic Science, Department of Nutrition, Tokyo Kasei University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan"},{"name":"Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2015,8,3]]},"reference":[{"key":"2021033114170487200_CIT0001","first-page":"1","author":"Eastoe","year":"1967","journal-title":"Treaties on collagen"},{"key":"2021033114170487200_CIT0002","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1185\/030079908X291967","article-title":"24-week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain","volume":"24","author":"Clark","year":"2008","journal-title":"Curr. 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