{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:31:40Z","timestamp":1793824300843,"version":"4.6.1"},"reference-count":36,"publisher":"Informa UK Limited","issue":"10","license":[{"start":{"date-parts":[[2015,10,3]],"date-time":"2015-10-03T00:00:00Z","timestamp":1443830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"JSPS","award":["20228002"],"award-info":[{"award-number":["20228002"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Here, we investigated the protective effect of cacao polyphenol extract (CPE) on carbon tetrachloride (CCl4)-induced hepato-renal oxidative stress in rats. Rats were administered CPE for 7\u00a0days and then received intraperitoneal injection of CCl4. Two hours after injection, we found that CCl4 treatment significantly increased biochemical injury markers, lipid peroxides (phosphatidylcholine hydroperoxide (PCOOH) and malondialdehyde (MDA)) and decreased glutathione peroxidase activity in kidney rather than liver, suggesting that kidney is more vulnerable to oxidative stress under the present experimental conditions. CPE supplementation significantly reduced these changes, indicating that this compound has antioxidant properties against CCl4-induced oxidative stress. An inhibitory effect of CPE on CCl4-induced CYP2E1 mRNA degradation may provide an explanation for CPE antioxidant property. Together, these results provide quantitative evidence of the in vivo antioxidant properties of CPE, especially in terms of PCOOH and MDA levels in the kidneys of CCl4-treated rats.<\/jats:p>","DOI":"10.1080\/09168451.2015.1039481","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T17:21:31Z","timestamp":1432228891000},"page":"1669-1675","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":25,"title":["Carbon tetrachloride-induced hepatic and renal damages in rat: inhibitory effects of cacao polyphenol"],"prefix":"10.1080","volume":"79","author":[{"given":"Koichiro","family":"Suzuki","sequence":"first","affiliation":[{"name":"Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan"},{"name":"Research Institute, Morinaga and Company Ltd., Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Research Institute, Morinaga and Company Ltd., Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan"},{"name":"Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Kamei","sequence":"additional","affiliation":[{"name":"Research Institute, Morinaga and Company Ltd., Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruo","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan"},{"name":"Food Biotechnology Innovation Project, NICHe, Tohoku University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2015,10,3]]},"reference":[{"key":"2021033114163172900_CIT0001","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1007\/s11894-005-0024-y","article-title":"Clinical implications of oxidative stress and antioxidant therapy","volume":"7","author":"Dryden","year":"2005","journal-title":"Curr. 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