{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:36:03Z","timestamp":1789727763135,"version":"4.0.1"},"reference-count":22,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T00:00:00Z","timestamp":1451692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CdSe quantum dots (QDs) are potential fluorescent reagents, but leakage of Cd and Se often induces cytotoxicity. Here we prepared CdSe-based QDs with glass to reduce their leakage and examined their cytotoxicity using keratinocyte cells. The cytotoxicity of the QDs with glass was obviously lower than that of the commercial QDs with polymer, suggesting their safety for biological applications.<\/jats:p>","DOI":"10.1080\/09168451.2015.1069702","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T08:03:17Z","timestamp":1523347397000},"page":"210-213","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":12,"title":["Cytotoxicity of CdSe-based quantum dots incorporated in glass nanoparticles evaluated using human keratinocyte HaCaT cells"],"prefix":"10.1080","volume":"80","author":[{"given":"Masanori","family":"Ando","sequence":"first","affiliation":[{"name":"Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Horie","sequence":"additional","affiliation":[{"name":"Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Akazawa-Ogawa","sequence":"additional","affiliation":[{"name":"Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Hagihara","sequence":"additional","affiliation":[{"name":"Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Murase","sequence":"additional","affiliation":[{"name":"Research Institute of Electrochemical Energy, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Shigeri","sequence":"additional","affiliation":[{"name":"Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,1,2]]},"reference":[{"key":"2021033107581089100_CIT0001","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/(ISSN)1521-3773","article-title":"Colloidal semiconductor Q-particles: chemistry in the transition region between solid state and molecules","volume":"32","author":"Weller","year":"1993","journal-title":"Angew. Chem. Int. Ed"},{"key":"2021033107581089100_CIT0002","doi-asserted-by":"publisher","first-page":"8706","DOI":"10.1021\/ja00072a025","article-title":"Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites","volume":"115","author":"Murray","year":"1993","journal-title":"J. Am. Chem. Soc"},{"key":"2021033107581089100_CIT0003","doi-asserted-by":"publisher","first-page":"4717","DOI":"10.1016\/j.biomaterials.2007.07.014","article-title":"Biological applications of quantum dots","volume":"28","author":"Jamieson","year":"2007","journal-title":"Biomaterials"},{"key":"2021033107581089100_CIT0004","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.chembiol.2010.11.013","article-title":"Biocompatible quantum dots for biological applications","volume":"18","author":"Rosenthal","year":"2011","journal-title":"Chem. Biol"},{"key":"2021033107581089100_CIT0005","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1039\/C3CS60273G","article-title":"Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy","volume":"43","author":"Biju","year":"2014","journal-title":"Chem. Soc. Rev"},{"key":"2021033107581089100_CIT0006","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1021\/nl049170q","article-title":"Fluorescent CdSe\/ZnS nanocrystal-peptide conjugates for long-term, nontoxic imaging and nuclear targeting in living cells","volume":"4","author":"Chen","year":"2004","journal-title":"Nano Lett"},{"key":"2021033107581089100_CIT0007","doi-asserted-by":"publisher","first-page":"4595","DOI":"10.1039\/c002243h","article-title":"Bright, non-blinking, and less-cytotoxic SiO2 beads with multiple CdSe\/ZnS nanocrystals","volume":"46","author":"Yang","year":"2010","journal-title":"Chem. Commun"},{"key":"2021033107581089100_CIT0008","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1021\/nl0347334","article-title":"Probing the cytotoxicity of semiconductor quantum dots","volume":"4","author":"Derfus","year":"2004","journal-title":"Nano Lett"},{"key":"2021033107581089100_CIT0009","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1289\/ehp.8284","article-title":"A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors","volume":"114","author":"Hardman","year":"2006","journal-title":"Environ. Health Perspect"},{"key":"2021033107581089100_CIT0010","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/smll.200900626","article-title":"In vivo quantum-dot toxicity assessment","volume":"6","author":"Hauck","year":"2010","journal-title":"Small"},{"key":"2021033107581089100_CIT0011","doi-asserted-by":"publisher","first-page":"7039","DOI":"10.1039\/c1cc10692a","article-title":"Some aspects of quantum dot toxicity","volume":"47","author":"Bottrill","year":"2011","journal-title":"Chem. Commun"},{"key":"2021033107581089100_CIT0012","doi-asserted-by":"publisher","first-page":"9545","DOI":"10.1016\/j.biomaterials.2013.08.038","article-title":"Cellular uptake, elimination and toxicity of CdSe\/ZnS quantum dots in HepG2 cells","volume":"34","author":"Peng","year":"2013","journal-title":"Biomaterials"},{"key":"2021033107581089100_CIT0013","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1039\/C2NR33024E","article-title":"InP\/ZnS as a safer alternative to CdSe\/ZnS core\/shell quantum dots: in vitro and in vivo toxicity assessment.","volume":"5","author":"Brunetti","year":"2013","journal-title":"Nanoscale"},{"key":"2021033107581089100_CIT0014","unstructured":"https:\/\/www.lifetechnologies.com\/jp\/ja\/home\/references\/molecular-probes-the-handbook\/ultrasensitive-detection-technology\/qdot-nanocrystal-technology.html"},{"key":"2021033107581089100_CIT0015","doi-asserted-by":"publisher","first-page":"14455","DOI":"10.1021\/jp201214k","article-title":"Highly luminescent CdSe\/CdxZn1\u2013xS quantum dots with narrow spectrum and widely tunable wavelength","volume":"115","author":"Yang","year":"2011","journal-title":"J. Phys. Chem. C"},{"key":"2021033107581089100_CIT0016","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.colsurfa.2011.11.031","article-title":"Silica encapsulation of highly luminescent hydrophobic quantum dots by two-step microemulsion method","volume":"395","author":"Wang","year":"2012","journal-title":"Colloids Surf. A"},{"key":"2021033107581089100_CIT0017","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jcis.2013.08.053","article-title":"Formation mechanism of highly luminescent silica capsules incorporating multiple hydrophobic quantum dots with various emission wavelengths","volume":"411","author":"Li","year":"2013","journal-title":"J. Colloid Interface Sci"},{"key":"2021033107581089100_CIT0018","first-page":"S2","article-title":"Photoluminescence analysis of neurons using glass beads with multiple CdSe\/ZnS quantum dots","volume":"85","author":"Hosokawa","year":"2010","journal-title":"Proc. 8th Annual Meeting of Soc. of Nano Sci. and Tech","ISSN":"https:\/\/id.crossref.org\/issn\/1347-8082","issn-type":"print"},{"key":"2021033107581089100_CIT0019","unstructured":"https:\/\/tools.lifetechnologies.com\/content\/sfs\/manuals\/mp10198.pdf"},{"key":"2021033107581089100_CIT0020","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1021\/tx800289z","article-title":"Protein adsorption of ultrafine metal oxide and its influence on cytotoxicity toward cultured cells","volume":"22","author":"Horie","year":"2009","journal-title":"Chem. Res. Toxicol"},{"key":"2021033107581089100_CIT0021","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1021\/tx900171n","article-title":"Ultrafine NiO particles induce cytotoxicity in vitro by cellular uptake and subsequent Ni(II) release","volume":"22","author":"Horie","year":"2009","journal-title":"Chem. Res. Toxicol"},{"key":"2021033107581089100_CIT0022","doi-asserted-by":"publisher","first-page":"e52198","DOI":"10.3791\/52198","article-title":"Production and targeting of monovalent quantum dots","volume":"92","author":"Seo","year":"2014","journal-title":"J. Vis. Exp"}],"container-title":["Bioscience, Biotechnology, and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bbb\/article-pdf\/80\/1\/210\/36807828\/bbb0210.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bbb\/article-pdf\/80\/1\/210\/36807828\/bbb0210.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T19:59:30Z","timestamp":1660852770000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bbb\/article\/80\/1\/210\/5939121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,2]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,2]]},"published-print":{"date-parts":[[2016,1,2]]}},"URL":"https:\/\/doi.org\/10.1080\/09168451.2015.1069702","relation":{},"ISSN":["0916-8451","1347-6947"],"issn-type":[{"value":"0916-8451","type":"print"},{"value":"1347-6947","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,1,2]]},"published":{"date-parts":[[2016,1,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbbb20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbbb20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2015-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}