{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:39:06Z","timestamp":1760549946140,"version":"3.37.3"},"reference-count":34,"publisher":"Informa UK Limited","issue":"5","license":[{"start":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T00:00:00Z","timestamp":1462233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"the Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["25350112"],"award-info":[{"award-number":["25350112"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Murine contact hypersensitivity (CHS) is one of the most frequently used animal models of human allergic contact dermatitis. We investigated the inhibitory effects of soybean and soy isoflavone (SI) diets on 2,4-dinitrofluorobenzene- (DNFB) induced CHS in mice. The DNFB-induced ear swelling was inhibited in the soy- and SI-treated groups. Histopathological investigations revealed that oral feeding of soybean and SI attenuated ear tissue edema and reduced the number of Gr-1+ cell infiltrations into ear tissues. DNA microarray analysis showed that the expression of Ccl24, Xcl1, Ifng, and Ccl17 in the ear tissues was lower in the soy-treated mice than in the positive controls. In addition, CCL24 mRNA and protein expression in the ear tissues were more highly suppressed in the soy- and SI-treated groups. These results suggest that soybean and SI consumption downregulated the gene and protein expression of CCL24, thereby affording protection against CHS in mice.<\/jats:p>","DOI":"10.1080\/09168451.2015.1132150","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T00:29:48Z","timestamp":1454459388000},"page":"991-997","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":18,"title":["The inhibitory effect of soybean and soybean isoflavone diets on 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice"],"prefix":"10.1080","volume":"80","author":[{"given":"Takao","family":"Nagano","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woruna","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunobu","family":"Tsumura","sequence":"additional","affiliation":[{"name":"Fuji Oil Co., Ltd., Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Yonemoto-Yano","sequence":"additional","affiliation":[{"name":"Fuji Oil Co., Ltd., Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoari","family":"Kamada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Haruma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2016,5,3]]},"reference":[{"key":"2021033109303325300_CIT0001","doi-asserted-by":"crossref","first-page":"758S","DOI":"10.1093\/jn\/129.3.758S","article-title":"Dietary isoflavones: Biological effects and relevance to human health","volume":"129","author":"Setchell","year":"1999","journal-title":"J. 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