{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:35:10Z","timestamp":1761129310480},"reference-count":28,"publisher":"Informa UK Limited","issue":"7","license":[{"start":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T00:00:00Z","timestamp":1467417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Ministry of Agriculture, Food and Rural Affairs, Republic of Korea","award":["313028-3"],"award-info":[{"award-number":["313028-3"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Inappropriate platelet aggregation can cause blood coagulation and thrombosis. In this study, the effect of an ethanol extract of Ramulus mori (ERM) on blood circulation was investigated. The antithrombotic activity of ERM on rat carotid arterial thrombosis was evaluated in vivo, and the effect of ERM on platelet aggregation and blood coagulation time was evaluated ex vivo. To evaluate the safety of ERM, its cytotoxicity to platelets and its effect on tail bleeding time were assessed; ERM was not toxic to rat platelets and did not prolong bleeding time. Moreover, administering ERM to rats had a significant preventive effect on carotid arterial thrombosis in vivo, and significantly inhibited adenosine diphosphate- and collagen-induced platelet aggregation ex vivo, whereas it did not prolong coagulation periods, such as prothrombin time and activated partial thromboplastin time. The results suggest that ERM is effective in improving blood circulation via antiplatelet activity rather than anticoagulation activity.<\/jats:p>","DOI":"10.1080\/09168451.2016.1156479","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T18:14:15Z","timestamp":1457720055000},"page":"1410-1415","update-policy":"http:\/\/dx.doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":6,"title":["An ethanol extract of <i>Ramulus mori<\/i> improves blood circulation by inhibiting platelet aggregation"],"prefix":"10.1080","volume":"80","author":[{"given":"Jiyun","family":"Lee","sequence":"first","affiliation":[{"name":"Departmentof Public Health Science (BK21 PLUS Program), Graduate School, Korea University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayeung","family":"Kwon","sequence":"additional","affiliation":[{"name":"Departmentof Public Health Science (BK21 PLUS Program), Graduate School, Korea University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieun","family":"Park","sequence":"additional","affiliation":[{"name":"Departmentof Public Health Science (BK21 PLUS Program), Graduate School, Korea University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Biotechnology, Korea Polytechnic University, Shihung-si, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Young","family":"Choe","sequence":"additional","affiliation":[{"name":"Department of Biology, Chungbuk National University, Chungbuk, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoonhee","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Biology, Chungbuk National University, Chungbuk, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Hee","family":"Lim","sequence":"additional","affiliation":[{"name":"Departmentof Public Health Science (BK21 PLUS Program), Graduate School, Korea University, Seoul, Republic of Korea"},{"name":"School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2016,7,2]]},"reference":[{"key":"2021033109321100700_CIT0001","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1159\/000075548","article-title":"Inhibitory effects of J78, a newly synthesized 1,4-naphthoquinone derivative, on experimental thrombosis and platelet aggregation","volume":"70","author":"Jin","year":"2004","journal-title":"Pharmacology"},{"key":"2021033109321100700_CIT0002","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.thromres.2011.09.013","article-title":"Use of anticoagulants in elderly patients","volume":"129","author":"Bauersachs","year":"2012","journal-title":"Thromb. 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