{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:42:47Z","timestamp":1787006567837,"version":"build-2736575974"},"reference-count":31,"publisher":"Informa UK Limited","issue":"8","license":[{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Shaanxi Province Science and Technology Plan Project of Social Development Plans for Public Relations","award":["S2009SF471"],"award-info":[{"award-number":["S2009SF471"]}]},{"name":"Shaanxi Province Science and Technology Plan Project of Social Development Plans for Public Relations","award":["2012SF2-13"],"award-info":[{"award-number":["2012SF2-13"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tenascin-C (TN-C) is an extracellular matrix glycoprotein markedly upregulated during liver fibrosis. The study is performed to explore the role of TN-C during the growth and activation of hepatic stellate cells (HSCs). We found that TN-C was accumulated accompanying with the HSC activation. Our data on cell migration assay revealed that the rTN-C treatment enhanced HSC migration in a dose- and time-dependent manner, but did not influence their proliferation. HSCs transfected with pTARGET-TN-C overexpression vector displayed increased the type I collagen (Col I) production. TN-C overexpression enhanced the process of HSC activation through TGF-\u03b21 signaling. Moreover, the anti-\u03b19\u03b21 integrin antibody treatment blocked the TN-C-driven Col I increase in rat HSCs. Collectively, TN-C had a positive role in activation of HSCs mediated by TGF-\u03b21 and \u03b19\u03b21 integrin, manifesting elevation of Col I production and promotion of cell migration. Our results provide a potential insight for the therapy of hepatic fibrosis.<\/jats:p>","DOI":"10.1080\/09168451.2016.1165600","type":"journal-article","created":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T14:33:14Z","timestamp":1459521194000},"page":"1470-1477","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["Tenascin-C promotes migration of hepatic stellate cells and production of type I collagen"],"prefix":"10.1080","volume":"80","author":[{"given":"Jian-Cang","family":"Ma","sequence":"first","affiliation":[{"name":"Department of General Surgery, Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Xi\u2019an Central Hospital, Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Wei","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Xi\u2019an Central Hospital, Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Xi\u2019an Central Hospital, Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Hua","family":"Su","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Kai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,8,2]]},"reference":[{"key":"2021033109500377300_CIT0001","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1055\/s-2001-17558","article-title":"Hepatic stellate cells as a target for the treatment of liver fibrosis","volume":"21","author":"Bataller","year":"2001","journal-title":"Semin. 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