{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:04:00Z","timestamp":1776222240668,"version":"3.50.1"},"reference-count":35,"publisher":"Informa UK Limited","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We investigated the efficacy of supplementing the diet with choline or betaine in ameliorating lipid accumulation induced by vitamin B6 (B6) deficiency in rat liver. Male Wistar rats were fed a control, B6-deficient, choline-supplemented (2, 4, or 6\u00a0g choline bitartrate\/kg diet) B6-deficient diet or betaine-supplemented (1, 2, or 4\u00a0g betaine anhydrous\/kg diet) B6-deficient diet for 35 d; all diets contained 9\u00a0g l-methionine (Met)\/kg diet. Choline or betaine supplementation attenuated liver lipid deposition and restored plasma lipid profiles to control levels. These treatments restored the disruptions in Met metabolism and the phosphatidylcholine (PC)\/phosphatidylethanolamine (PE) ratio induced by B6 deficiency in liver microsomes. These results suggest that choline and betaine ameliorated liver lipid accumulation induced by B6 deficiency via recovery of Met metabolism and very low-density lipoprotein secretion by restoring the supply of PC derived from PE.<\/jats:p>","DOI":"10.1080\/09168451.2016.1240604","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T11:16:31Z","timestamp":1475579791000},"page":"316-322","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":15,"title":["Choline and betaine ameliorate liver lipid accumulation induced by vitamin B6 deficiency in rats"],"prefix":"10.1080","volume":"81","author":[{"given":"Erina","family":"Kitagawa","sequence":"first","affiliation":[{"name":"The United Graduate School of Agricultural Science, Gifu University, Gifu, Japan"},{"name":"Faculty of Health and Human Life, Nagoya Bunri University, Inazawa, 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