{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:41:58Z","timestamp":1776922918573,"version":"3.51.2"},"reference-count":24,"publisher":"Informa UK Limited","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Skeletal muscle is an important organ for controlling the development of type 2 diabetes. We discovered Panax notoginseng roots as a candidate to improve hyperglycemia through in vitro muscle cells screening test. Saponins are considered as the active ingredients of ginseng. However, in the body, saponins are converted to dammarane-type triterpenes, which may account for the anti-hyperglycemic activity. We developed a method for producing a dammarane-type triterpene extract (DTE) from Panax notoginseng roots and investigated the extract\u2019s potential anti-hyperglycemic activity. We found that DTE had stronger suppressive activity on blood glucose levels than the saponin extract (SE) did in KK-Ay mice. Additionally, DTE improved oral glucose tolerance, insulin sensitivity, glucose uptake, and Akt phosphorylation in skeletal muscle. These results suggest that DTE is a promising agent for controlling hyperglycemia by enhancing glucose uptake in skeletal muscle.<\/jats:p>","DOI":"10.1080\/09168451.2016.1246173","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T07:32:11Z","timestamp":1477294331000},"page":"335-342","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":19,"title":["Dammarane-type triterpene extracts of <i>Panax notoginseng<\/i> root ameliorates hyperglycemia and insulin sensitivity by enhancing glucose uptake in skeletal muscle"],"prefix":"10.1080","volume":"81","author":[{"given":"Kumiko","family":"Kitamura","sequence":"first","affiliation":[{"name":"Research and Development Headquarters, Lion Corporation, Odawara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Takamura","sequence":"additional","affiliation":[{"name":"Research and Development Headquarters, Lion Corporation, Odawara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Research and Development Headquarters, Lion Corporation, Odawara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Nomura","sequence":"additional","affiliation":[{"name":"Research and Development Headquarters, Lion Corporation, Odawara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Research and Development Headquarters, Lion Corporation, Odawara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyasu","family":"Ohdera","sequence":"additional","affiliation":[{"name":"Research and Development Headquarters, Lion Corporation, Odawara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiaki","family":"Murakoshi","sequence":"additional","affiliation":[{"name":"Research and Development Headquarters, Lion Corporation, Odawara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keikichi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Research and Development Headquarters, Lion Corporation, Odawara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Hachioji, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Manabe","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Hachioji, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuharu L","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Hachioji, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Fushiki","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2017,2,1]]},"reference":[{"key":"2021040104311450400_CIT0001","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/j.cell.2012.02.010","article-title":"Diabetes mellitus and the \u03b2 cell: the last ten years","volume":"148","author":"Ashcroft","year":"2012","journal-title":"Cell"},{"key":"2021040104311450400_CIT0002","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/BF00402279","article-title":"Glycated haemoglobin, plasma glucose and diabetic retinopathy: cross-sectional and prospective analyses","volume":"36","author":"Liu","year":"1993","journal-title":"Diabetologia"},{"key":"2021040104311450400_CIT0003","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1001\/archinte.1994.00420190068008","article-title":"Relationship of hyperglycemia to the long-term incidence and progression of diabetic retinopathy","volume":"154","author":"Klein","year":"1994","journal-title":"Arch Intern Med"},{"key":"2021040104311450400_CIT0004","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.2337\/diacare.18.8.1113","article-title":"Veterans affairs cooperative study on glycemic control and complications in type II diabetes (VA CSDM). 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