{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:13:24Z","timestamp":1790651604604,"version":"4.1.0"},"reference-count":51,"publisher":"Informa UK Limited","issue":"7","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We previously reported that exogenous application of auxin to Arabidopsis seedlings resulted in downregulation of indole-3-acetic acid (IAA) biosynthesis genes in a feedback manner. In this study, we investigated the involvement of the SCFTIR1\/AFB-mediated signaling pathway in feedback regulation of the indole-3-pyruvic acid-mediated auxin biosynthesis pathway in Arabidopsis. Application of PEO-IAA, an inhibitor of the IAA signal transduction pathway, to wild-type seedlings resulted in increased endogenous IAA levels in roots. Endogenous IAA levels in the auxin-signaling mutants axr2-1, axr3-3, and tir1-1afb1-1afb2-1afb3-1 also increased. Furthermore, YUCCA (YUC) gene expression was repressed in response to auxin treatment, and expression of YUC7 and YUC8 increased in response to PEO-IAA treatment. YUC genes were also induced in auxin-signaling mutants but repressed in TIR1-overexpression lines. These observations suggest that the endogenous IAA levels are regulated by auxin biosynthesis in a feedback manner, and the Aux\/IAA and SCFTIR1\/AFB-mediated auxin-signaling pathway regulates the expression of YUC genes.<\/jats:p>","DOI":"10.1080\/09168451.2017.1313694","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T10:10:11Z","timestamp":1492078211000},"page":"1320-1326","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":48,"title":["Auxin signaling through SCFTIR1\/AFBs mediates feedback regulation of IAA biosynthesis"],"prefix":"10.1080","volume":"81","author":[{"given":"Shin","family":"Takato","sequence":"first","affiliation":[{"name":"Kihara Institute for Biological Research, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kakei","sequence":"additional","affiliation":[{"name":"Kihara Institute for 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