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In this study, the antidepressant-like effect of methaolic extracts from Sargassum swartzii (SS), Stoechospermum marginatum (SM), and Nizamuddinia zanardinii (NZ) was examined in forced swimming test (FST), in rats. Oral administration of SS, SM, and NZ extract (30\u201360\u00a0mg\/kg) exhibited antidepressant-like activity in FST by reducing immobility time as compared to control group, without inducing significant change in ambulatory behavior in open field test. In order to evaluate the involvement of monoaminergic system, rats were pretreated with the inhibitor of brain serotonin stores p-chlorophenylalanin (PCPA), dopamine (SCH23390 and sulpiride), and adrenoceptor (prazosin and propranolol) antagonists. Rats receiving treatment for 28\u00a0days were decapitated and brains were analyzed for monoamine levels. It may be concluded that the extracts of SS, SM, and NZ produces antidepressant-like activity via modulation of brain monoaminergic system in a rat model.<\/jats:p>","DOI":"10.1080\/09168451.2017.1313697","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T10:16:26Z","timestamp":1492078586000},"page":"1369-1378","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["Antidepressant-like deliverables from the sea: evidence on the efficacy of three different brown seaweeds via involvement of monoaminergic system"],"prefix":"10.1080","volume":"81","author":[{"given":"Pirzada Jamal Ahmed","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Centre of Excellence in Marine Biology, University of Karachi, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Khan","sequence":"additional","affiliation":[{"name":"Centre of Excellence in Marine Biology, University of Karachi, Karachi, Pakistan"},{"name":"Karachi Institute of Radiotherapy and Nuclear Medicine (KIRAN), Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizam","family":"Uddin","sequence":"additional","affiliation":[{"name":"Centre of Excellence in Marine Biology, University of Karachi, Karachi, Pakistan"},{"name":"Batterje Medical College for Science & Technology, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Khaliq","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Federal Urdu University, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munawwer","family":"Rasheed","sequence":"additional","affiliation":[{"name":"Centre of Excellence in Marine Biology, University of Karachi, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia","family":"Nawaz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Federal Urdu University, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Hanif","sequence":"additional","affiliation":[{"name":"Karachi Institute of Radiotherapy and Nuclear Medicine (KIRAN), Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsana","family":"Dar","sequence":"additional","affiliation":[{"name":"International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2017,7,3]]},"reference":[{"key":"2021033109414927200_CIT0001","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrn1846","article-title":"New approaches to antidepressant drug discovery: beyond monoamines","volume":"7","author":"Berton","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"2021033109414927200_CIT0002","first-page":"590","article-title":"Innovative approaches for the development of antidepressant drugs: current and future strategies","volume":"2","author":"Schechter","year":"2005","journal-title":"J Am Soc Exp Neurother"},{"key":"2021033109414927200_CIT0003","first-page":"517","article-title":"Pharmacology of antidepressants","volume":"76","author":"Rechelson","year":"2001","journal-title":"Mayo Clin Proc"},{"key":"2021033109414927200_CIT0004","unstructured":"The world health report . 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