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In this study, we evaluated its effect on aging in senescence-accelerated mouse prone 8 (SAMP8) mice. Male SAMP8 mice had free access to a commercial stock diet and drinking water with or without GPC (0.07\u00a0mg\/ml). Mice in the GPC group had significantly lower total senescence grading score than that of the control group at 36\u00a0weeks of age. Administration of GPC decreased the deposition of transthyretin (TTR), an amyloidogenic protein, in the brain. Aggregated TTR activated microglia and led to neuroinflammation. Thus, GPC would protect the brain by reducing TTR deposition and preventing neuroinflammation. In a histological study of knee joints, it was found that SAMP8 mice administered GPC showed decreased joint degeneration. These results suggest that GPC delays the aging process and may be a useful compound in anti-aging functional food development.<\/jats:p>","DOI":"10.1080\/09168451.2017.1403883","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T09:05:41Z","timestamp":1512119141000},"page":"647-653","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":20,"title":["The delaying effect of alpha-glycerophosphocholine on senescence, transthyretin deposition, and osteoarthritis in senescence-accelerated mouse prone 8 mice"],"prefix":"10.1080","volume":"82","author":[{"given":"Kiminori","family":"Matsubara","sequence":"first","affiliation":[{"name":"Department of Human Life Science Education, Graduate School of Education, Hiroshima University, Higashi-Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Okuda","sequence":"additional","affiliation":[{"name":"Department of 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