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Geranylgeraniol (GGOH) is an isoprenoid found in plants, and is an important metabolic derivative in the isoprenoid\/cholesterol synthesis pathway. Earlier studies focused on GGOH\u2019s ability to improve the side effects of bisphosphonate therapy by regulating the mevalonate pathway. More recently, the mevalonate pathway-independent effects of GGOH have been described, including anti-inflammatory, anti-tumorigenic, and neuroprotective activities. It is noteworthy that GGOH regulates the steroidogenesis pathway in testis-derived I-10 tumor cells. Testosterone is a hormone produced via steroidogenesis in testicles and plays a role in fetal development and the male reproductive system. GGOH enhanced testosterone and progesterone (its precursor) levels in I-10 cells by activating adenylate cyclase via cAMP\/PKA signaling, without altering phosphodiesterase activity. These findings highlight the potential benefits of GGOH as a therapeutic agent for low testosterone levels, such as late-onset hypogonadism in men.<\/jats:p>","DOI":"10.1080\/09168451.2017.1415129","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T10:11:34Z","timestamp":1515147094000},"page":"956-962","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":46,"title":["A novel function of geranylgeraniol in regulating testosterone production"],"prefix":"10.1080","volume":"82","author":[{"given":"Hsin-Jung","family":"Ho","sequence":"first","affiliation":[{"name":"Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Shirakawa","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, 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