{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T14:17:43Z","timestamp":1772288263499,"version":"3.50.1"},"reference-count":25,"publisher":"Informa UK Limited","issue":"4","license":[{"start":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T00:00:00Z","timestamp":1522713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alcoholic beverages are enjoyed together with meals worldwide, but their excessive intake is associated with an increased risk of various diseases. We investigated whether S-allyl-L-cysteine sulfoxide (ACSO), a sulfuric odor precursor of garlic, suppresses elevation in plasma ethanol concentration by accelerating ethanol metabolism and preventing ethanol absorption from the gut in rats. ACSO and garlic extract with a high ACSO content (Garlic-H) suppressed elevation in concentrations of ethanol and acetaldehyde in plasma and promoted the activities of alcohol dehydrogenase and aldehyde dehydrogenase. However, ACSO and Garlic-H did not affect plasma acetate so much. Furthermore, we examined the change in plasma ethanol concentration by injecting ACSO or Garlic-H into the ligated stomach or jejunum together with ethanol solution. ACSO and Garlic-H suppressed the absorption of ethanol from the stomach and jejunum, but suppression in the jejunum was less than in the stomach. In conclusion, ACSO inhibits ethanol absorption and accelerates ethanol metabolism.<\/jats:p>","DOI":"10.1080\/09168451.2018.1447357","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T14:30:07Z","timestamp":1522852207000},"page":"724-731","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":16,"title":["<i>S<\/i>-Allyl-L-cysteine sulfoxide, a garlic odor precursor, suppresses elevation in blood ethanol concentration by accelerating ethanol metabolism and preventing ethanol absorption from gut"],"prefix":"10.1080","volume":"82","author":[{"given":"Harumi","family":"Uto-Kondo","sequence":"first","affiliation":[{"name":"Department of Bioscience in Daily Life, Nihon University, Fujisawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumu","family":"Hase","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Life Science, Nihon University, Fujisawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Life Science, Nihon University, Fujisawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaka","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Life Science, Nihon University, Fujisawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Akao","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Life Science, Nihon University, Fujisawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Saito","sequence":"additional","affiliation":[{"name":"ACERA Co., Ltd., Kofu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Life Science, Nihon University, Fujisawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2018,4,3]]},"reference":[{"issue":"6","key":"2021040707005389100_CIT0001","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1007\/s11883-012-0277-5","article-title":"Alcohol intake revisited: risks and benefits","volume":"14","author":"Roerecke","year":"2012","journal-title":"Curr Atheroscler Rep"},{"issue":"10","key":"2021040707005389100_CIT0002","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1007\/s10552-008-9173-2","article-title":"Alcohol and risk of lung cancer among Japanese men: data from a large-scale population-based cohort study, the JPHC study","volume":"19","author":"Shimazu","year":"2008","journal-title":"Cancer Causes Control"},{"issue":"1","key":"2021040707005389100_CIT0003","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1093\/jjco\/hym152","article-title":"Alcohol drinking and gastric cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population","volume":"38","author":"Shimazu","year":"2008","journal-title":"Jpn J Clin Oncol"},{"issue":"5","key":"2021040707005389100_CIT0004","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1093\/alcalc\/agt063","article-title":"Sulforaphane accelerates acetaldehyde metabolism by inducing aldehyde dehydrogenases: relevance to ethaenol intolerance","volume":"48","author":"Ushida","year":"2013","journal-title":"Alcohol Alcohol"},{"issue":"9","key":"2021040707005389100_CIT0005","first-page":"637","article-title":"Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia","volume":"5","author":"Peleg","year":"2003","journal-title":"Isr Med Assoc J"},{"issue":"3","key":"2021040707005389100_CIT0006","doi-asserted-by":"publisher","first-page":"1067S","DOI":"10.1093\/jn\/131.3.1067S","article-title":"enhanced immunocompetence by garlic: role in bladder cancer and other malignancies","volume":"131","author":"Lamm","year":"2001","journal-title":"J Nutr"},{"issue":"3","key":"2021040707005389100_CIT0007","doi-asserted-by":"publisher","first-page":"1032S","DOI":"10.1093\/jn\/131.3.1032S","article-title":"Garlic and cancer: a critical review of the epidemiologic literature","volume":"131","author":"Fleischauer","year":"2001","journal-title":"J Nutr"},{"issue":"1","key":"2021040707005389100_CIT0008","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2174\/1568009033333736","article-title":"Garlic [Allium sativum]: a review of its potential use as an anti-cancer agent","volume":"3","author":"Thomson","year":"2003","journal-title":"Curr Cancer Drug Targets"},{"issue":"3","key":"2021040707005389100_CIT0009","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/scientificamerican0385-114","article-title":"The chemistry of garlic and onions","volume":"252","author":"Block","year":"1985","journal-title":"Sci Am"},{"issue":"5","key":"2021040707005389100_CIT0010","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1007\/s11373-008-9257-8","article-title":"Garlic allyl derivatives interact with membrane lipids to modify the membrane fluidity","volume":"15","author":"Tsuchiya","year":"2008","journal-title":"J Biomed Sci"},{"issue":"Suppl. 1","key":"2021040707005389100_CIT0011","first-page":"502","article-title":"In vivo production of bioactive compounds from S-allyl-L-cysteine sulfoxide, garlic odor precursor, that inhibit platelet aggregation","volume":"43","author":"Akao","year":"2008","journal-title":"J Clin Biochem Nutr"},{"key":"2021040707005389100_CIT0012","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1155\/2017\/5849593","article-title":"Rapid elimination of blood alcohol using erythrocytes: mathematical modeling in in vitro study","volume":"2017","author":"Alexandrovich","year":"2017","journal-title":"BioMed Res Int"},{"issue":"3","key":"2021040707005389100_CIT0013","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1055\/s-2006-960969","article-title":"Quantitative determination of allicin and alliin from garlic by HPLC*","volume":"56","author":"Iberl","year":"1990","journal-title":"Planta Med"},{"issue":"50","key":"2021040707005389100_CIT0014","doi-asserted-by":"publisher","first-page":"10778","DOI":"10.1021\/acs.jafc.5b05501","article-title":"A simple synthesis of alliin and allo-alliin: x-ray diffraction analysis and determination of their absolute configurations","volume":"63","author":"Hakamata","year":"2015","journal-title":"J Agric Food Chem"},{"issue":"7","key":"2021040707005389100_CIT0015","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1271\/bbb.68.1598","article-title":"Enhanced calcium absorption in the small intestine by a phytate-removed deamidated soybean globulin preparation","volume":"68","author":"Kumagai","year":"2004","journal-title":"Biosci Biotechnol Biochem"},{"issue":"3","key":"2021040707005389100_CIT0016","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1042\/bj1520709","article-title":"Role of cytosolic rat liver aldehyde dehydrogenase in the oxidation of acetaldehyde during ethanol metabolism in vivo","volume":"152","author":"Eriksson","year":"1975","journal-title":"Biochem J"},{"key":"2021040707005389100_CIT0017","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1136\/bmj.300.6719.230","article-title":"Analysis of serial measurements in medical research","volume":"300","author":"Matthews","year":"1990","journal-title":"BMJ"},{"issue":"6","key":"2021040707005389100_CIT0018","first-page":"837","article-title":"Structural mutation in a major human aldehyde dehydrogenase gene results in loss of enzyme activity","volume":"34","author":"Impraim","year":"1982","journal-title":"Am J Hum Genet"},{"key":"2021040707005389100_CIT0019","first-page":"G951","article-title":"Use of measurements of ethanol absorption from stomach and intestine to assess human ethanol metabolism","volume":"273","author":"Levitt","year":"1997","journal-title":"Am J Physiol"},{"issue":"6","key":"2021040707005389100_CIT0020","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1002\/hep.22010","article-title":"Determinants of alcohol use and abuse: Impact of quantity and frequency patterns on liver disease","volume":"46","author":"Zakhari","year":"2007","journal-title":"Hepatology"},{"key":"2021040707005389100_CIT0021","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3177\/jnsv.45.275","article-title":"Combined effects of ethanol and garlic on hepatic ethanol metabolism in mice","volume":"45","author":"Kishimoto","year":"1999","journal-title":"J Nutr Sci Vitaminol"},{"issue":"9","key":"2021040707005389100_CIT0022","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nrgastro.2011.134","article-title":"Alcoholic liver disease: pathogenesis and new targets for therapy","volume":"8","author":"Altamirano","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"5","key":"2021040707005389100_CIT0023","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.alcohol.2008.03.131","article-title":"Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium","volume":"42","author":"Purohit","year":"2008","journal-title":"Alcohol"},{"issue":"9","key":"2021040707005389100_CIT0024","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/S1471-4914(01)02096-2","article-title":"Alcoholic liver disease: new insights into mechanisms and preventative strategies","volume":"7","author":"Stewart","year":"2001","journal-title":"Trends Mol Med"},{"issue":"5","key":"2021040707005389100_CIT0025","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/acer.2011.35.issue-5","article-title":"Molecular mechanisms of alcoholic liver disease: innate immunity and cytokines","volume":"35","author":"Miller","year":"2011","journal-title":"Alcohol Clin Exp Res"}],"container-title":["Bioscience, Biotechnology, and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bbb\/article-pdf\/82\/4\/724\/36942215\/bbb0724.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bbb\/article-pdf\/82\/4\/724\/36942215\/bbb0724.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T11:52:10Z","timestamp":1654602730000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bbb\/article\/82\/4\/724\/5938739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,3]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,3]]},"published-print":{"date-parts":[[2018,4,3]]}},"URL":"https:\/\/doi.org\/10.1080\/09168451.2018.1447357","relation":{},"ISSN":["0916-8451","1347-6947"],"issn-type":[{"value":"0916-8451","type":"print"},{"value":"1347-6947","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,4,3]]},"published":{"date-parts":[[2018,4,3]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbbb20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbbb20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2017-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}