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A biologically active small molecule may save directly or indirectly a number of people. Even if the molecule has not been used as a therapeutic agent, it can be used as a useful chemical probe for dissecting a living cell into different biochemical pieces. Such biologically active small molecules derived from microorganisms have been primarily found in cultivable microorganisms that make up only 1% of total microbes in nature. Discovery of novel growth factors, zincmethylphyrin, zinc coproporphyrin, and coproporphyrin enabled laboratory cultivation of previously uncultured Leucobacter sp. These findings might expand the possibility for further discovery of novel therapeutic agents or chemical probes.<\/jats:p>","DOI":"10.1080\/09168451.2018.1451740","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T13:40:41Z","timestamp":1521639641000},"page":"1063-1072","update-policy":"http:\/\/dx.doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["The logic of biologically active small molecules: amazing ability of microorganisms*"],"prefix":"10.1080","volume":"82","author":[{"given":"Makoto","family":"Ubukata","sequence":"first","affiliation":[{"name":"Graduate School of Agriculture, Hokkaido University , Kita-ku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2018,7,3]]},"reference":[{"key":"2021040104595712900_CIT0001","doi-asserted-by":"publisher","first-page":"3473","DOI":"10.1016\/S0040-4039(01)83269-X","article-title":"Stereoselective synthesis of (\u00b1)-palitantin","author":"Ichihara","year":"1977","journal-title":"Tetrahedron Lett"},{"key":"2021040104595712900_CIT0002","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/S0040-4020(01)83120-3","article-title":"Stereoselecgive synthesis of (\u00b1)-palitantin (full paper)","volume":"36","author":"Ichihara","year":"1980","journal-title":"Tetrahedron"},{"key":"2021040104595712900_CIT0003","doi-asserted-by":"publisher","first-page":"4469","DOI":"10.1016\/S0040-4039(00)92203-2","article-title":"Total synthesis of (\u00b1)-nanaomycin A and (\u00b1)-frenolicin","volume":"21","author":"Ichihara","year":"1980","journal-title":"Tetrahedron Lett"},{"key":"2021040104595712900_CIT0004","first-page":"211","article-title":"Synthesis of plumbagin by the retro-Diels Alder reaction","volume":"44","author":"Ichihara","year":"1980","journal-title":"Agric Biol Chem"},{"key":"2021040104595712900_CIT0005","unstructured":"Ubukata \u00a0M . 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