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We transfected four recombinant miRNA vectors into GBC-SD. We performed the wound healing assays and invasion assays. The result shows that the heparanase expression was significantly decreased by recombinant vectors in transfected GBC-SD cells (p\u00a0&amp;lt;\u00a00.01), of which pmiR-Hpa-2 showed best interference effect (p\u00a0&amp;lt;\u00a00.05). The penetrated and migrating cells numbers and adherence rate of GBC-SD cells were significantly decreased by pmiR-Hpa-2 (p\u00a0&amp;lt;\u00a00.05).<\/jats:p>","DOI":"10.1080\/09168451.2018.1456316","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T06:28:35Z","timestamp":1522391315000},"page":"1116-1122","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":4,"title":["Gene silencing of heparanase results in suppression of invasion and migration of gallbladder carcinoma cells"],"prefix":"10.1080","volume":"82","author":[{"given":"Hao","family":"Jin","sequence":"first","affiliation":[{"name":"The Second Department of General Surgery, Zhuhai People\u2019s Hospital , Zhuhai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Cui","sequence":"additional","affiliation":[{"name":"The Second Department of General Surgery, Zhuhai People\u2019s Hospital , Zhuhai, 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