{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:21:59Z","timestamp":1776993719939,"version":"3.51.4"},"reference-count":43,"publisher":"Informa UK Limited","issue":"9","license":[{"start":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T00:00:00Z","timestamp":1535846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003712","name":"Korea Food Research Institute","doi-asserted-by":"publisher","award":["E0170401-02"],"award-info":[{"award-number":["E0170401-02"]}],"id":[{"id":"10.13039\/501100003712","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003712","name":"Korea Food Research Institute","doi-asserted-by":"publisher","award":["E0170401-02"],"award-info":[{"award-number":["E0170401-02"]}],"id":[{"id":"10.13039\/501100003712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,9,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Allergic contact dermatitis (ACD) is an inflammatory skin disease caused by hapten-specific immune response. Silkworm droppings are known to exert beneficial effects during the treatment of inflammatory diseases. Here, we studied whether topical treatment and oral administration of silkworm dropping extract (SDE) ameliorate trimellitic anhydride (TMA)-induced ACD. In ACD mice model, SDE treatment significantly suppressed the increase in both ear thickness and serum IgE levels. Furthermore, IL-1\u03b2 and TNF-\u03b1 levels were reduced by SDE. In allergic responses, SDE treatment significantly attenuated the production of the Th2-associated cytokine IL-4 in both ear tissue and draining lymph nodes. However, it increased the production of the Th1-mediated cytokine IL-12. Thus, these results showed that SDE attenuated TMA-induced ACD symptoms through regulation of Th1\/Th2 immune response. Taken together, we suggest that SDE treatment might be a potential agent in the prevention or therapy of Th2-mediated inflammatory skin diseases such as ACD and atopic dermatitis.<\/jats:p><jats:p>Abbreviations: ACD: allergic contact dermatitis; AD: atopic dermatitis; APC: antigen presenting cells; CCL: chemokine (C-C motif) ligand; CCR: C-C chemokine receptor; Dex: dexamethasone; ELISA: enzyme-linked immunosorbent assay; IFN: interferon; Ig: immunoglobulin; IL: interleukin; OVA: ovalbumin; PS: prednisolone; SDE: silkworm dropping extract; Th: T helper; TMA: trimellitic anhydride; TNF: tumor necrosis factor<\/jats:p>","DOI":"10.1080\/09168451.2018.1475210","type":"journal-article","created":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T13:59:06Z","timestamp":1527343146000},"page":"1531-1538","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["Silkworm dropping extract ameliorate trimellitic anhydride-induced allergic contact dermatitis by regulating Th1\/Th2 immune response"],"prefix":"10.1080","volume":"82","author":[{"given":"Dae Woon","family":"Choi","sequence":"first","affiliation":[{"name":"Food Biotechnology Program, Korea University of Science and Technology, Republic of Korea"},{"name":"Division of Nutrition and Metabolism Research, Korea Food Research Institute, Wanju-gun, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Ae","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism Research, Korea Food Research Institute, Wanju-gun, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Keun","family":"Jung","sequence":"additional","affiliation":[{"name":"Food Biotechnology Program, Korea University of Science and Technology, Republic of Korea"},{"name":"Division of Functional Food Research, Korea Food Research Institute, Wanju-gun, Republic of Korea"},{"name":"School 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