{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:18:40Z","timestamp":1789474720695,"version":"build-2803163510"},"reference-count":36,"publisher":"Informa UK Limited","issue":"12","license":[{"start":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T00:00:00Z","timestamp":1543708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"MEXT KAKENHI","award":["25292073"],"award-info":[{"award-number":["25292073"]}]},{"name":"MEXT KAKENHI","award":["16K14928"],"award-info":[{"award-number":["16K14928"]}]},{"name":"MEXT KAKENHI","award":["and 17H03818 (YN)"],"award-info":[{"award-number":["and 17H03818 (YN)"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Benzyl isothiocyanate (BITC) is an organosulfur compound derived from cruciferous vegetables and papaya seeds. In this study, we investigated the effect of BITC on the lipid accumulation in 3T3-L1 preadipocytes during adipocyte differentiation. The treatment of BITC during the differentiation-inducing stage significantly ameliorated the lipid accumulation, whereas it had no inhibitory effect during the differentiation-maintaining stage. BITC also significantly suppressed the mRNA expression of the adipocyte-specific markers, such as CCAAT\/enhancer-binding protein \u03b1 (C\/EBP\u03b1), C\/EBP\u03b2, C\/EBP\u03b4 and peroxisome proliferator-activated receptor \u03b3. BITC significantly inhibited the phosphorylation of extracellular signal-regulated kinase phosphorylation, whereas it enhanced that of AMP-activated protein kinase. Furthermore, BITC significantly suppressed the intracellular 2-deoxyglucose uptake as well as glucose transporter 4 expression. These results suggest that inhibition of the adipocyte differentiation and glucose uptake may mainly contribute to the inhibitory effect of BITC on the lipid accumulation in 3T3-L1 preadipocytes.<\/jats:p>\n               <jats:p>Abbreviations: PPAR\u03b3: peroxisome proliferator-activated receptor \u03b3; CEBP: CCAAT\/enhancer-binding protein; GLUT4: glucose transporter 4; AMPK: AMP-activated protein kinase; ERK1\/2: extracellular signal-regulated kinase 1\/2; MAPK: a mitogen-activated protein kinase; ITCs: isothiocyanates; BITC: benzyl isothiocyanate; FBS: fetal bovine serum; CS: calf serum; AITC: allyl ITC; IBMX: 3-isobutyl-1-methylxanthine; LDH: lactate dehydrogenase; KRH: Krebs-Ringer-Hepes-bicarbonate; 2-DG: 2-deoxy-d-glucose<\/jats:p>","DOI":"10.1080\/09168451.2018.1514247","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T06:34:47Z","timestamp":1536215687000},"page":"2130-2139","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Benzyl isothiocyanate ameliorates lipid accumulation in 3T3-L1 preadipocytes during adipocyte differentiation"],"prefix":"10.1080","volume":"82","author":[{"given":"Ying","family":"Liang","sequence":"first","affiliation":[{"name":"Graduate School of Environmental and Life Science, Okayama University, Okayama Japan"},{"name":"School of Food Science and Technology, Dalian Polytechnic University, Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Graduate School of Environmental and Life Science, Okayama University, Okayama 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