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STS accelerated hair growth in the \u201ctelogen model\u201d, suggesting that it stimulates telogen hair follicles to reenter the anagen phase of hair growth. In the same model, STS potentiated hair growth in an additive manner with minoxidil (MXD), a drug used for the treatment of androgenic alopecia. Furthermore, in the \u201canagen model\u201d, STS promoted hair growth, probably by promoting hair follicle proliferation. Since STS elevated the skin surface temperature, its hair growth-promoting activity may be partly due to vasorelaxation, similar to MXD. In addition, STS is known to generate a gaseous mediator, H2S, which has vasorelaxation and anti-inflammatory\/anti-oxidative stress activities. Therefore, STS and\/or provisionally its metabolite, H2S, may aid the hair growth process. Collectively, these results suggest that salts of thiosulfate may represent a novel and beneficial remedy for hair loss.<\/jats:p>","DOI":"10.1080\/09168451.2018.1518705","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T04:30:09Z","timestamp":1536640209000},"page":"114-122","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Thiosulfate promotes hair growth in mouse model"],"prefix":"10.1080","volume":"83","author":[{"given":"Motoko","family":"Maekawa","sequence":"first","affiliation":[{"name":"Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Saitama, 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