{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T06:59:19Z","timestamp":1768114759246,"version":"3.49.0"},"reference-count":30,"publisher":"Informa UK Limited","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Oxytocin is produced by neurons in the paraventricular nucleus (PVN) and the supraoptic nucleus in the hypothalamus. Various ion channels are considered to regulate the excitability of oxytocin neurons and its secretion. A-type currents of voltage-gated potassium channels (Kv channels), generated by Kv4.2\/4.3 channels, are known to be involved in the regulation of neuron excitability. However, it is unclear whether the Kv4.2\/4.3 channels participate in the regulation of excitability in PVN oxytocin neurons. Here, we investigated the contribution of the Kv4.2\/4.3 channels to PVN oxytocin neuron excitability. By using transgenic rat brain slices with the oxytocin-monomeric red fluorescent protein 1\u00a0fusion transgene, we examined the excitability of oxytocin neurons by electrophysiological technique. In some oxytocin neurons, the application of Kv4.2\/4.3 channel blocker increased firing frequency and membrane potential with extended action potential half-width. Our present study indicates the contribution of Kv4.2\/4.3 channels to PVN oxytocin neuron excitability regulation.<\/jats:p>\n               <jats:p>Abbreviation: PVN, paraventricular nucleus; Oxt-mRFP1, Oxt-monometric red fluorescent protein 1; PaTx-1, Phrixotoxin-1; TEA, Tetraethylammonium Chloride; TTX, tetrodotoxin; aCSF, artificial cerebrospinal fluid;PBS, phosphate buffered saline 3v, third ventricle.<\/jats:p>","DOI":"10.1080\/09168451.2018.1537773","type":"journal-article","created":{"date-parts":[[2018,11,4]],"date-time":"2018-11-04T15:54:13Z","timestamp":1541346853000},"page":"202-211","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":6,"title":["Excitability of oxytocin neurons in paraventricular nucleus is regulated by voltage-gated potassium channels Kv4.2 and Kv4.3"],"prefix":"10.1080","volume":"83","author":[{"given":"Ryota","family":"Imai","sequence":"first","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan"},{"name":"Tsumura Kampo Research Laboratories, Kampo Research & Development Division, Tsumura & Co., Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichiro","family":"Horita","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Ueta","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Maejima","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenju","family":"Shimomura","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2019,2,1]]},"reference":[{"key":"2021033115534002200_CIT0001","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/physrev.2001.81.2.629","article-title":"The oxytocin receptor system: structure, function, and regulation","volume":"81","author":"Gimpl","year":"2001","journal-title":"Physiol Rev"},{"key":"2021033115534002200_CIT0002","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nature03701","article-title":"Oxytocin increases trust in humans","volume":"435","author":"Kosfeld","year":"2005","journal-title":"Nature"},{"key":"2021033115534002200_CIT0003","doi-asserted-by":"crossref","first-page":"193","DOI":"10.31887\/DCNS.2017.19.2\/cjones","article-title":"Oxytocin and social functioning","volume":"19","author":"Jones","year":"2017","journal-title":"Dialogues Clin Neurosci"},{"key":"2021033115534002200_CIT0004","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1016\/j.febslet.2014.10.010","article-title":"Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus","volume":"588","author":"Maejima","year":"2014","journal-title":"FEBS Lett"},{"key":"2021033115534002200_CIT0005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000371636","article-title":"Nasal oxytocin administration reduces food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas","volume":"101","author":"Maejima","year":"2015","journal-title":"Neuroendocrinology"},{"key":"2021033115534002200_CIT0006","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.18632\/aging.100408","article-title":"Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass","volume":"3","author":"Maejima","year":"2011","journal-title":"Aging (Albany NY)"},{"key":"2021033115534002200_CIT0007","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/oby.21069","article-title":"Schoenfeld DA and Tolley CJ. 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