{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:54:21Z","timestamp":1777596861848,"version":"3.51.4"},"reference-count":27,"publisher":"Informa UK Limited","issue":"3","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"JSPS KAKENHI","award":["25350112"],"award-info":[{"award-number":["25350112"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,3,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Contact hypersensitivity (CHS) is frequently used as an animal model for human allergic contact dermatitis (ACD). Diets of pomegranate polyphenols (PPs) or soy isoflavones (SIs) each alleviated CHS symptoms; however, the effect of diets containing a mixture of PPs and SIs on CHS is unclear. We investigated the CHS-inhibitory effects of diets supplemented with a mixture of PPs and SIs at human physiologically relevant doses. Consuming the mixture of PPs and SIs attenuated ear swelling and reduced infiltration of Gr-1-positive cells. Ear swelling decreased in the PP and SI-treated mice compared to the SI-treated mice. The auricle tissues of the PP and SI-fed mice exhibited decreased production of CXCL2 and MCP-5 compared to the SI- and PP-treated mice, respectively. These results suggest that dietary supplementation with a mixture of PPs and SIs may have ACD-preventive effects and may prove more beneficial than supplementation with PPs or SIs alone.<\/jats:p>","DOI":"10.1080\/09168451.2018.1543013","type":"journal-article","created":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T12:48:56Z","timestamp":1541854136000},"page":"525-530","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["Diets containing pomegranate polyphenol and soy isoflavone attenuate contact hypersensitivity in mice"],"prefix":"10.1080","volume":"83","author":[{"given":"Takao","family":"Nagano","sequence":"first","affiliation":[{"name":"Department of Food Science, Faculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Ishikawa, Japan"},{"name":"Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2019,3,4]]},"reference":[{"key":"2021033115585177000_CIT0001","first-page":"382763","article-title":"Pomegranate protection against cardiovascular diseases","volume":"2012","author":"Aviram","year":"2012","journal-title":"Evid Based Comp Alter Med"},{"issue":"3","key":"2021033115585177000_CIT0002","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/10408390802064404","article-title":"Food ellagitannins\u2013occurrence, Effects of processing and storage","volume":"49","author":"Bakkalba\u015fi","year":"2008","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"10","key":"2021033115585177000_CIT0003","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1021\/jf000404a","article-title":"Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing","volume":"48","author":"Gil","year":"2000","journal-title":"J Agric Food Chem"},{"issue":"7","key":"2021033115585177000_CIT0004","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1080\/10408391003748100","article-title":"The bioactivity of pomegranate: impact on health and disease","volume":"51","author":"Faria","year":"2011","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"2","key":"2021033115585177000_CIT0005","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.canlet.2008.03.043","article-title":"Multitargeted therapy of cancer by ellagitannins","volume":"269","author":"Heber","year":"2008","journal-title":"Cancer Lett"},{"issue":"6","key":"2021033115585177000_CIT0006","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.mam.2010.09.005","article-title":"Ellagitannins, ellagic acid and vascular health","volume":"31","author":"Larrosa","year":"2010","journal-title":"Mol Asp Med"},{"key":"2021033115585177000_CIT0007","doi-asserted-by":"crossref","first-page":"423S","DOI":"10.3945\/ajcn.113.071464","article-title":"Soy foods, isoflavones, and the health of postmenopausal women","volume":"100","author":"Messina","year":"2014","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"2021033115585177000_CIT0008","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/jjco\/hyt203","article-title":"Research group for the, J. 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