{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:28:37Z","timestamp":1774524517250,"version":"3.50.1"},"reference-count":42,"publisher":"Informa UK Limited","issue":"3","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"no funding"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,3,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study investigated the effects of proanthocyanidins derived from Acacia (Acacia mearnsii) bark extract in healthy Japanese adult subjects experiencing uncomfortable skin symptoms. All subjects were randomly allocated into two groups (n =\u00a033 each) using a computerized random-number generator. The subjects received either Acacia bark extract tablets or placebo for 8\u00a0weeks. Evaluations included water content in the stratum corneum, transepidermal water loss (TEWL), Skindex-16, dermatology life quality index (DLQI), visual analog scale for desire to scratch, and blood tests. At 4\u00a0weeks, the symptom\/feeling score of DLQI, subjective symptoms related to uncomfortable skin, and the desire to scratch were significantly reduced in the intervention group than in the placebo group. At 8\u00a0weeks, the intervention group exhibited significantly lower TEWL on facial skin than that in the placebo group. In conclusion, the intake of Acacia bark extract tablets reduced TEWL and improved dry and uncomfortable skin.<\/jats:p>","DOI":"10.1080\/09168451.2018.1547626","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T12:31:53Z","timestamp":1544445113000},"page":"538-550","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Impact of Acacia bark extract tablets on the skin of healthy humans: a randomized, double-blind, placebo-controlled study"],"prefix":"10.1080","volume":"83","author":[{"given":"Tomohiro","family":"Hoshino","sequence":"first","affiliation":[{"name":"R&D Department, ORTHOMEDICO Inc., Bunkyo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichiro","family":"Yamashita","sequence":"additional","affiliation":[{"name":"R&D Department, ORTHOMEDICO Inc., Bunkyo-ku, Tokyo, 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