{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:48:26Z","timestamp":1769816906537,"version":"3.49.0"},"reference-count":16,"publisher":"Informa UK Limited","issue":"12","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,12,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Three new flavonol glycosides, fissflavosides A-C (1\u20133), together with six known flavonol glycosides, kaempferol 3-O-\u03b1-L-rhamnopyranosyl-(1\u21922)-\u03b2-D-galactopyranoside (4), kaempferol 3-O-\u03b1-L-rhamnopyranosyl-(1\u21926)-\u03b2-D-galactopyranoside (5), kaempferol 3-O-\u03b1-L-rhamnopyranosyl-(1\u21926)-\u03b2-D-glucopyranoside (6), rhamnetin 3-O-\u03b1-L-rhamnopyranosyl-(1\u21922)-\u03b2-D-glucopyranoside (7), rutin (8), and isorhamnetin 3-O-\u03b1-L-rhamnopyranosyl-(1\u21922)-\u03b2-D-galactopyranoside (9) were isolated from the methanol extract of the Fissistigma pallens leaves. Their chemical structures were determined by 1D-, 2D-NMR, and MS data as well as in comparison with reported data in the literature. Compounds 1\u20139 showed weak cytotoxic activity on three human cancer cell lines, HT-29, A-2058, A-549 with IC50 ranging from 134.6 to 162.6 \u00b5M. In addition, the antioxidant capacities of compounds were also tested by ORAC assay. All compounds showed significant antioxidant with trolox equivalents ranging from 4.4 to 8.6 \u00b5M at the concentration of 1.0 \u00b5M. The results indicated 7 and 8 having meaningful reducing capacity of copper (I) ions of 2.7 to 6.9 \u00b5M at the concentrations of 1 and 2 \u00b5M.<\/jats:p>","DOI":"10.1080\/09168451.2019.1654848","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T06:44:32Z","timestamp":1566801872000},"page":"2177-2182","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":6,"title":["Three new flavonol glycosides from <i>Fissistigma pallens<\/i>"],"prefix":"10.1080","volume":"83","author":[{"given":"Nguyen Xuan","family":"Nhiem","sequence":"first","affiliation":[{"name":"Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Cau Giay, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngo Sy","family":"Thinh","sequence":"additional","affiliation":[{"name":"National Institute of Medicinal Materials, Hoan Kiem, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi Bich","family":"Thu","sequence":"additional","affiliation":[{"name":"National Institute of Medicinal Materials, Hoan Kiem, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luu The","family":"Anh","sequence":"additional","affiliation":[{"name":"Central Institute for Natural Resources and Environmental Studies, Vietnam National National University, Hoan Kiem, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran","family":"Minh Ngoc","sequence":"additional","affiliation":[{"name":"National Institute of Medicinal Materials, Hoan Kiem, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui Huu","family":"Tai","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Cau Giay, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pham Hai","family":"Yen","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Cau Giay, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan Van","family":"Kiem","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Cau Giay, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chau","family":"Van Minh","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Cau Giay, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seonju","family":"Park","sequence":"additional","affiliation":[{"name":"Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"2021033109503372400_CIT0001","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0031-9422(00)82561-3","article-title":"Alkaloids of formosan Fissistigma and Goniothalamus species","volume":"24","author":"Lu","year":"1985","journal-title":"Phytochemistry"},{"key":"2021033109503372400_CIT0002","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1248\/cpb.60.280","article-title":"New flavan and benzil isolated from Fissistigma latifolium","volume":"60","author":"Lan","year":"2012","journal-title":"Chem Pharm Bull"},{"key":"2021033109503372400_CIT0003","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0040-4020(99)01049-2","article-title":"Fissistigmatins A-D: novel type natural products with flavonoid-sesquiterpene hybrid structure from Fissistigma bracteolatum","volume":"56","author":"Porzel","year":"2000","journal-title":"Tetrahedron"},{"key":"2021033109503372400_CIT0004","unstructured":"Dai \u00a0DN\n           \u00a0Study on biological characteristics, oil chemical components of genera belong to Annonaceae Juss in Northern-Central of Vietnam \u00a0[PhD Dissertation]. 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