{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:05:22Z","timestamp":1785247522375,"version":"3.55.0"},"reference-count":43,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Walnut is a nutritious food material, but only a few studies have been conducted on the mechanisms of its functions and the technique for quality evaluation. Therefore, we analyzed the components in aqueous methanol extract of walnut, and characterized 30 components, including three new compounds, glansreginin C, ellagic acid 4-O-(3\u2032-O-galloyl)-\u03b2-D-xyloside, and platycaryanin A methyl ester. We analyzed the extracts of other nuts using HPLC and clarified that a characteristic peak corresponding to glansreginin A was mainly observed in walnut. These results suggested that glansreginin A might be an indicator component of the quality of walnut. We then examined whether glansreginin A has neuroprotective effect, using lipopolysaccharide (LPS)-induced inflammatory model mice. The results revealed that oral administration of glansreginin A prevented LPS-induced abnormal behavior and LPS-induced hyper-activation of microglia in the hippocampus. These results suggested that glansreginin A has the ability to exert neuroprotective effect via anti-inflammation in the brain.<\/jats:p>","DOI":"10.1080\/09168451.2019.1670046","type":"journal-article","created":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T06:46:32Z","timestamp":1569653192000},"page":"187-197","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":24,"title":["Identification of the characteristic components in walnut and anti-inflammatory effect of glansreginin A as an indicator for quality evaluation"],"prefix":"10.1080","volume":"84","author":[{"given":"Rie","family":"Haramiishi","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, Matsuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, Matsuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morio","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, Matsuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsunari","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, Matsuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, Matsuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Faculty of Health and Welfare Science, Department of Nutritional Science, Okayama Prefectural University, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Amakura","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, Matsuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,1,2]]},"reference":[{"key":"2021033116071788700_CIT0001","unstructured":"Ministry of Agriculture, Forestry and Fisheries, aff, MAFF TOPICS. (Japanese). 2011 Oct [cited 2019 Jun18]. Available from: http:\/\/www.maff.go.jp\/j\/pr\/aff\/1110\/spe2_03.html."},{"key":"2021033116071788700_CIT0002","unstructured":"Ministry of Education, Culture, Sports, Science and Technology, Standard tables of food composition in Japan - 2015- (Seventh Revised Version)."},{"key":"2021033116071788700_CIT0003","doi-asserted-by":"crossref","first-page":"1062S","DOI":"10.1093\/jn\/132.5.1062S","article-title":"The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease","volume":"132","author":"Feldman","year":"2002","journal-title":"J Nutr"},{"key":"2021033116071788700_CIT0004","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0031-9422(03)00333-9","article-title":"Antioxidative polyphenols from walnuts (Juglans regia L.)","volume":"63","author":"Fukuda","year":"2003","journal-title":"Phytochemistry"},{"key":"2021033116071788700_CIT0005","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1021\/jf062872b","article-title":"Two novel dicarboxylic acid derivatives and a new dimeric hydrolyzable tannin from walnuts","volume":"55","author":"Ito","year":"2007","journal-title":"J Agric Food Chem"},{"key":"2021033116071788700_CIT0006","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/ajcn\/nqy091","article-title":"Effects of walnut consumption on blood lipids and other cardiovascular risk factors: an updated meta-analysis and systematic review of controlled trials","volume":"108","author":"Guasch-Ferr\u00e9","year":"2018","journal-title":"Am J Clin Nutr"},{"key":"2021033116071788700_CIT0007","doi-asserted-by":"crossref","first-page":"547S","DOI":"10.3945\/jn.113.182907","article-title":"Walnuts decrease risk of cardiovascular disease: summary of efficacy and biologic mechanisms","volume":"144","author":"Kris-Etherton","year":"2014","journal-title":"J Nutr"},{"key":"2021033116071788700_CIT0008","doi-asserted-by":"crossref","first-page":"e3031","DOI":"10.1002\/dmrr.3031","article-title":"Association between walnut consumption and diabetes risk in NHANES","volume":"34","author":"Arab","year":"2018","journal-title":"Diabetes Metab Res Rev"},{"key":"2021033116071788700_CIT0009","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1021\/jf8002174","article-title":"Walnut polyphenols prevent liver damage induced by carbon tetrachloride and D-galactosamine: hepatoprotective hydrolyzable tannins in the kernel pellicles of walnut","volume":"56","author":"Shimoda","year":"2008","journal-title":"J Agric Food Chem"},{"key":"2021033116071788700_CIT0010","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1021\/jf803441c","article-title":"Effect of polyphenol-rich extract from walnut on diet-induced hypertriglyceridemia in mice via enhancement of fatty acid oxidation in the liver","volume":"57","author":"Shimoda","year":"2009","journal-title":"J Agric Food Chem"},{"key":"2021033116071788700_CIT0011","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.3945\/jn.116.234419","article-title":"Consumption of walnuts in combination with other whole foods produces physiologic, metabolic, and gene expression changes in obese C57BL\/6J high-fat\u2013fed male mice","volume":"146","author":"Luo","year":"2016","journal-title":"J Nutr"},{"key":"2021033116071788700_CIT0012","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.3233\/JAD-140675","article-title":"Dietary supplementation of walnuts improves memory deficits and learning skills in transgenic mouse model of Alzheimer\u2019s disease","volume":"42","author":"Muthaiyah","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"2021033116071788700_CIT0013","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1007\/s11064-011-0533-z","article-title":"Protective effects of walnut extract against amyloid beta peptide-induced cell death and oxidative stress in PC12 cells","volume":"36","author":"Muthaiyah","year":"2011","journal-title":"Neurochem Res"},{"key":"2021033116071788700_CIT0014","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jnutbio.2017.07.001","article-title":"Changes in the gut microbial communities following addition of walnuts to the diet","volume":"48","author":"Byerley","year":"2017","journal-title":"J Nutr Biochem"},{"key":"2021033116071788700_CIT0015","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1017\/S0007114507837421","article-title":"Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483","volume":"99","author":"Papoutsi","year":"2008","journal-title":"Br J Nutr"},{"key":"2021033116071788700_CIT0016","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1248\/cpb.55.899","article-title":"Facile discrimination of aldose enantiomers by reversed-phase HPLC","volume":"55","author":"Tanaka","year":"2007","journal-title":"Chem Pharm Bull"},{"key":"2021033116071788700_CIT0017","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/0040-4020(67)80076-0","article-title":"The structure of a C12-acid from the seed of Phaseolus multiflorus","volume":"23","author":"Macmillan","year":"1967","journal-title":"Tetrahedron"},{"key":"2021033116071788700_CIT0018","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1021\/ja01595a050","article-title":"Plant polyphenols. I. The polyphenolic constituents of the pellicle of the walnut (Juglans regia)","volume":"78","author":"Jurd","year":"1956","journal-title":"J Am Chem Soc"},{"key":"2021033116071788700_CIT0019","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/0031-9422(83)80105-8","article-title":"Flavanol glucoside from rhubarb and Rhaphiolepis umbellata","volume":"22","author":"Nonaka","year":"1983","journal-title":"Phytochemistry"},{"key":"2021033116071788700_CIT0020","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1248\/cpb.58.438","article-title":"Structural revisions of blumenol C glucoside and byzantionoside B","volume":"58","author":"Matsunami","year":"2010","journal-title":"Chem Pharm Bull"},{"key":"2021033116071788700_CIT0021","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1271\/bbb.130324","article-title":"Characterization of constituents in the peel of Citrus kawachiensis (Kawachibankan)","volume":"77","author":"Amakura","year":"2013","journal-title":"Biosci Biotechnol Biochem"},{"key":"2021033116071788700_CIT0022","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1021\/ja00980a054","article-title":"Selective exchange of nuclear protons in hydroxyindoles","volume":"89","author":"Daly","year":"1967","journal-title":"J Am Chem Soc"},{"key":"2021033116071788700_CIT0023","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1021\/jf304002h","article-title":"Chemical composition, antioxidative and anti-inflammatory activity of extracts prepared from aerial parts of Oenothera biennis L. and Oenothera paradoxa Hudziok obtained after seeds cultivation","volume":"61","author":"Granica","year":"2013","journal-title":"J Agric Food Chem"},{"key":"2021033116071788700_CIT0024","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0031-9422(97)00670-5","article-title":"Distribution of ellagic acid derivatives and a diarylheptanoid in wood of Platycarya strobilacea","volume":"47","author":"Tanaka","year":"1998","journal-title":"Phytochemistry"},{"key":"2021033116071788700_CIT0025","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1016\/j.bmcl.2005.08.022","article-title":"A new antitumor compound from the plant Oryctanthus sp. as a VEGF receptor binding inhibitor","volume":"15","author":"Hegde","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"2021033116071788700_CIT0026","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1039\/p19820002515","article-title":"The metabolism of gallic acid and hexahydroxydiphenic acid in plants. Part 1. Introduction. Naturally occurring galloyl esters","volume":"1","author":"Haddock","year":"1982","journal-title":"J Chem Soc Perkin Trans"},{"key":"2021033116071788700_CIT0027","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1016\/0031-9422(80)85058-8","article-title":"Ellagitannins of the casuarinaceae, stachyuraceae and myrtaceae","volume":"21","author":"Okuda","year":"1982","journal-title":"Phytochemistry"},{"key":"2021033116071788700_CIT0028","first-page":"211","article-title":"Ellagitannins from Tellima grandiflora. Phytochemistry","volume":"15","author":"Wilkins","year":"1976"},{"key":"2021033116071788700_CIT0029","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1039\/p19830001765","article-title":"Tannins of Casuarina and Stachyurus species. Part 1. Structures of pedunculagin, casuarictin, strictinin, casuarinin, casuariin and stachyurin","volume":"1","author":"Okuda","year":"1983","journal-title":"J Chem Soc Perkin Trans"},{"key":"2021033116071788700_CIT0030","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1248\/cpb.39.2233","article-title":"Tannins and related polyphenols of Melastomataceous Plants. I. Hydrolyzable tannins from Tibouchina semidecandra COGN","volume":"39","author":"Yoshida","year":"1991","journal-title":"Chem Pharm Bull"},{"key":"2021033116071788700_CIT0031","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1248\/cpb.30.4230","article-title":"Rugosin A, B, C and praecoxin A, tannins having a valoneoyl group","volume":"30","author":"Okuda","year":"1982","journal-title":"Chem Pharm Bull"},{"key":"2021033116071788700_CIT0032","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1055\/s-2006-961194","article-title":"Prostratins A and B: new hydrolysable tannin monomer and trimer from Euphorbia prostrate and Loropetalum chinense","volume":"56","author":"Namba","year":"1990","journal-title":"Plant Med"},{"key":"2021033116071788700_CIT0033","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1248\/cpb.41.1708","article-title":"Tannins and related compounds. CXXIV. Five new ellagitannins, platycaryanins A, B, C, and D, and platycariin, and a new complex tannin, strobilanin, from the fruits and bark of Platycarya strobilacea SIEB et ZUCC., and biomimetic synthesis of C-glycosidic ellagitannins from glucopyranose-based ellagitannins","volume":"41","author":"Tanaka","year":"1993","journal-title":"Chem Pham Bull"},{"key":"2021033116071788700_CIT0034","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1248\/cpb.40.1750","article-title":"Eucalbanins A, B and C, monomeric and dimeric hydrolyzable tannins from Eucalyptus alba REINW","volume":"40","author":"Yoshida","year":"1992","journal-title":"Chem Pharm Bull"},{"key":"2021033116071788700_CIT0035","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.phytochem.2017.02.006","article-title":"Hydrolyzable tannins from the fruits of Terminalia chebula Retz and their \u03b1-glucosidase inhibitory activities","volume":"137","author":"Lee","year":"2017","journal-title":"Phytochemistry"},{"key":"2021033116071788700_CIT0036","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.foodres.2014.08.009","article-title":"HPLC-MSn identification and quantification of polyphenolic compounds in hazelnut kernels, oil and bagasse pellets","volume":"64","author":"Slatnar","year":"2014","journal-title":"Food Res Int"},{"key":"2021033116071788700_CIT0037","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3390\/molecules23020435","article-title":"Dynamic changes in phenolics and antioxidant capacity during pecan (Carya illinoinensis) kernel ripening and its phenolics profiles","volume":"23","author":"Jia","year":"2018","journal-title":"Molecules"},{"key":"2021033116071788700_CIT0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2016.03.010","article-title":"The blood-brain barrier in systemic inflammation","volume":"60","author":"Varatharaj","year":"2017","journal-title":"Brain Behav Immun"},{"key":"2021033116071788700_CIT0039","doi-asserted-by":"crossref","first-page":"51647","DOI":"10.1074\/jbc.M407328200","article-title":"Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglia activation, interleukin-1\u03b2, and expression of caspase-11 in mice","volume":"279","author":"Arai","year":"2004","journal-title":"J Biol Chem"},{"key":"2021033116071788700_CIT0040","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuint.2014.02.008","article-title":"Systemic injection of LPS induces region-specific neuroinflammation and mitochondrial dysfunction in normal mouse brain","volume":"69","author":"Noh","year":"2014","journal-title":"Neurochem Int"},{"key":"2021033116071788700_CIT0041","doi-asserted-by":"crossref","first-page":"271359","DOI":"10.1155\/2013\/271359","article-title":"Systemic immune activation leads to neuroinflammation and sickness behavior in mice","volume":"2013","author":"Biesmans","year":"2013","journal-title":"Mediators Inflammation"},{"key":"2021033116071788700_CIT0042","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/01.WCB.0000111614.19196.04","article-title":"Pathophysiology of cerebral ischemia and brain trauma: similarities and differences","volume":"24","author":"Bramlett","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"key":"2021033116071788700_CIT0043","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.3390\/ijms19113678","article-title":"Anti-inflammatory and neuroprotective effects of fungal immunomodulatory protein involving microglial inhibition","volume":"19","author":"Chen","year":"2018","journal-title":"Int J Mol Sci"}],"container-title":["Bioscience, Biotechnology, and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bbb\/article-pdf\/84\/1\/187\/36834504\/bbb0187.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bbb\/article-pdf\/84\/1\/187\/36834504\/bbb0187.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T07:49:19Z","timestamp":1654588159000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bbb\/article\/84\/1\/187\/5937625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,2]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,2]]},"published-print":{"date-parts":[[2020,1,2]]}},"URL":"https:\/\/doi.org\/10.1080\/09168451.2019.1670046","relation":{},"ISSN":["0916-8451","1347-6947"],"issn-type":[{"value":"0916-8451","type":"print"},{"value":"1347-6947","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,1,2]]},"published":{"date-parts":[[2020,1,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbbb20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbbb20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}