{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:17:05Z","timestamp":1770819425525,"version":"3.50.1"},"reference-count":32,"publisher":"Informa UK Limited","issue":"10","license":[{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Doctoral Program of Guangdong Natural Science Foundation","award":["2015A030310068"],"award-info":[{"award-number":["2015A030310068"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mounting evidences indicate that autophagy is an essential homeostatic mechanism to maintain the global cardiac structure function. Sophocarpine (SOP), a major bioactive compound derived from the natural plant Sophora flavescens. However, the role of SOP in cardiac hypertrophy remain to be fully elucidated. In the present study, we tested the hypothesis that SOP protects against Ang II\u2013induced cardiac hypertrophy by mediating the regulation of autophagy. The results demonstrated that SOP attenuated the Ang II\u2013induced cardiac hypertrophy, as assessed by measurements of echocardiography parameters, the ratios of heart weight\/body weight and left ventricle weight\/body weight, histopathological staining, cross-sectional cardiomyocyte area, and the expression levels of cardiac hypertrophic markers. The anti-hypertrophic effect of SOP was mediated by activating autophagy-related pathway, as revealed by reversal of the increased autophagy marker protein expression. These findings reveal a novel mechanism of SOP attenuating cardiac hypertrophy via activating autophagy-related signaling pathways.<\/jats:p>","DOI":"10.1080\/09168451.2020.1780111","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T20:25:10Z","timestamp":1592339110000},"page":"2054-2061","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":4,"title":["Sophocarpine ameliorates cardiac hypertrophy through activation of autophagic responses"],"prefix":"10.1080","volume":"84","author":[{"given":"Yue-Bao","family":"Lin","sequence":"first","affiliation":[{"name":"Department of General Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Jian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan-Liang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Emergency, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Xiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong-Hua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Vasculocardiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,10,2]]},"reference":[{"issue":"7","key":"2021033109482214400_cit0001","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy[J]","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"2021033109482214400_cit0002","first-page":"1","article-title":"Inhibition of miR-296-5p protects the heart from cardiac hypertrophy by targeting CACNG6[J]","author":"Wang","year":"2019","journal-title":"Gene Ther"},{"issue":"1","key":"2021033109482214400_cit0003","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yexcr.2019.01.019","article-title":"CSN5 attenuates Ang II-induced cardiac hypertrophy through stabilizing LKB1[J]","volume":"376","author":"Sheng","year":"2019","journal-title":"Exp Cell 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