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Autism spectrum disorder (ASD) is a neurodevelopmental disorder that may be linked to neural and synaptic development impairments. The present study aimed to analyze the preventive effects of RSV on the development of ASD-like behavior, using oxytocin receptor gene knockout (Oxtr-KO) and valproic acid-induced ASD (VPA-ASD) model mice. Genetic deficiencies in Oxtr are suggested to be involved in ASD etiology. Twenty-four hours after a single RSV injection to the Oxtr-KO mice, the social impairments caused by OXTR deficiency were ameliorated. RSV also improved social impairments in the VPA-ASD mice. Administration of RSV up-regulated silent information regulator 1 (Sirt1) gene and early growth response factor 3 (Egr3) gene expressions in the amygdala of the Oxtr-KO mice. Our data suggest that RSV may have therapeutic effects on ASD with multiple targets.<\/jats:p>","DOI":"10.1080\/09168451.2020.1794783","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T01:26:08Z","timestamp":1595467568000},"page":"2207-2214","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":22,"title":["Single administration of resveratrol improves social behavior in adult mouse models of autism spectrum disorder"],"prefix":"10.1080","volume":"84","author":[{"given":"Shizu","family":"Hidema","sequence":"first","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University, Fukushima, Japan"},{"name":"Graduate School of Agricultural Science, Tohoku University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Graduate School of Agricultural 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