{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:33:41Z","timestamp":1793284421566,"version":"4.5.0"},"reference-count":54,"publisher":"Informa UK Limited","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Nanchong municipal government and North Sichuan Medical College scientific research strategic cooperation project","award":["18SXHZ0295"],"award-info":[{"award-number":["18SXHZ0295"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The objective of present investigation was to appraise the effects of piperine on STZ-induced diabetic cardiomyopathy in rats. Diabetes was induced in Sprague-Dawley rats with intraperitoneal STZ injection, and the rats were assigned to seven groups. Electrocardiograph, hemodynamic, various biochemical, molecular, and histological parameters were examined. Treatment with piperine significantly (p &amp;lt;\u00a00.05) restored altered myocardial functions, inhibited cardiac marker, and restored electrocardiogram and hemodynamic alterations. The elevated level of cardiac oxido-nitrosative stress and decreased cardiac Na-K-ATPase concentration, after STZ administration, were significantly (p &amp;lt;\u00a00.05) attenuated by piperine treatment. Piperine also considerably (p &amp;lt;\u00a00.05) increased myocardial mitochondrial enzyme activity. STZ-induced alteration in heart ANP, BNP, cTn-I, Bcl2, Bax\/Bcl2, and caspase3 mRNA expression was significantly (p &amp;lt;\u00a00.05) restored by piperine treatment. Piperine administration reduced histopathological aberrations induced by STZ. In conclusion, the present investigation suggests that piperine ameliorates STZ-induced diabetic cardiomyopathy via modulation of caspase-3, Bcl2, Bax\/Bcl2 pathways.<\/jats:p>\n               <jats:p>Abbreviations: ACE: Angiotensin-Converting Enzyme; ANOVA: Analysis of Variance; ANP: Atrial Natriuretic Peptide; APAF: Apoptotic Protease-Activating Factor; ARB: Angiotensin Receptor Blockers; ATP: Adenosine Triphosphate; Bax: Bcl-2-associated X protein; Bcl2: B-cell lymphoma 2; BPM: Beats Per Minute; BNP: brain natriuretic peptide; CAD: Caspase-3-Activated DNase; cDNA: Complementary DNA; CK-MB: Creatine Kinase-MB; CPCSEA: Committee for the Purpose of Control And Supervision of Experiments on Animals; cTn-I: cardiac troponin I; DBP: Diastolic Blood Pressure; DCM: Diabetic Cardiomyopathy; DNA: Deoxyribonucleic Acid; DPX: DisterenePhthalate Xylene; ECG: Electrocardiogram; ETC: Electron Transport Chain; GOD-POD: Glucose Oxidase Peroxidase; GSH: Glutathione; IAEC: Institutional Animal Ethics Committee; IL-6: Interleukin-6; IL-1b: Interleukin-1b; LDH: Lactate Dehydrogenase; LV: Left Ventricle; LVEDP: left ventricular end-diastolic Pressure; MABP: Mean Arterial Blood Pressure; MDA: Malondialdehyde; mRNA: Messenger Ribonucleic Acid; MTT: 3- (4,5-Dimethylthiazol-2-yl)-2,5-DiphenyltetrazoliumBromide; NADH: Nicotinamide Adenine Dinucleotide Phosphate; NADPH: Nicotinamide Adenine Dinucleotide Phosphate Hydrogen; NO: nitric oxide; NP: Natriuretic Peptides; OXPHOS: Oxidative Phosphorylation; p.o.: per os; PCR: Polymerase Chain Reaction; RT-PCR: Reverse Transcriptionpolymerase Chain Reaction; PPAR: Peroxisome Proliferator-Activated Receptor Gamma; RAS: Renin-Angiotensin System; RNA: Ribonucleic Acid; ROS: Reactive Oxygen Species; SBP: Systolic Blood Pressure; SDH: Succinate Dehydrogenase; SEM: Standard Error Means; SOD: superoxide dismutase: STZ: Streptozotocin; TNF: Tumor Necrosis Factor Alpha; TnI: Troponin I<\/jats:p>","DOI":"10.1080\/09168451.2020.1815170","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T02:39:15Z","timestamp":1599446355000},"page":"2533-2544","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":47,"title":["Streptozotocin-induced diabetic cardiomyopathy in rats: ameliorative effect of PIPERINE via Bcl2, Bax\/Bcl2, and caspase-3 pathways"],"prefix":"10.1080","volume":"84","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, North Sichuan Medical College, Nanchong City, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyang","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medicine, North Sichuan Medical College, Nanchong City, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medicine, North Sichuan Medical College, Nanchong City, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"issue":"2","key":"2021033116162048600_cit0001","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global estimates of diabetes prevalence for 2013 and projections for 2035","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"2021033116162048600_cit0002","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11154-010-9131-7","article-title":"Diabetic cardiomyopathy, causes and effects","volume":"11","author":"Boudina","year":"2010","journal-title":"Rev Endocr Metab Disord"},{"issue":"1","key":"2021033116162048600_cit0003","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5482\/HAMO-14-09-0038","article-title":"The vulnerable myocardium","volume":"35","author":"Bugger","year":"2015","journal-title":"H\u00e4mostaseologie"},{"issue":"5","key":"2021033116162048600_cit0004","first-page":"411","article-title":"Diabetic cardiomyopathy: from pathophysiology to treatment","volume":"55","author":"Trachanas","year":"2014","journal-title":"Hellenic J Cardiol"},{"issue":"3","key":"2021033116162048600_cit0005","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10741-011-9257-z","article-title":"Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment","volume":"17","author":"Falc\u00e3o-Pires","year":"2012","journal-title":"Heart Fail Rev"},{"issue":"10","key":"2021033116162048600_cit0006","doi-asserted-by":"crossref","first-page":"e78330","DOI":"10.1371\/journal.pone.0078330","article-title":"Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms","volume":"8","author":"Picatoste","year":"2013","journal-title":"PLoS One"},{"issue":"9","key":"2021033116162048600_cit0007","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ Res"},{"issue":"2","key":"2021033116162048600_cit0008","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bbadis.2014.06.030","article-title":"Interplay of oxidative, nitrosative\/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy","volume":"1852","author":"Varga","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"2021033116162048600_cit0009","doi-asserted-by":"crossref","first-page":"9932","DOI":"10.1038\/srep09932","article-title":"Magic electron affection in preparation process of silicon nanocrystal","volume":"5","author":"Huang","year":"2015","journal-title":"Sci Rep"},{"issue":"4","key":"2021033116162048600_cit0010","first-page":"247","article-title":"Cardioameliorative effect of punicalagin against streptozotocin-induced apoptosis, redox imbalance, metabolic changes and inflammation","volume":"2","author":"Mohamed","year":"2015","journal-title":"Egypt J Basic Appl Sci"},{"issue":"1","key":"2021033116162048600_cit0011","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12933-016-0383-8","article-title":"Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway","volume":"15","author":"Korkmaz-Ic\u00f6z","year":"2016","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"2021033116162048600_cit0012","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.taap.2012.12.005","article-title":"D-Saccharic acid 1, 4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-\u03baB and PKC signaling","volume":"267","author":"Bhattacharya","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"2021033116162048600_cit0013","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1475-2840-12-50","article-title":"Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy","volume":"12","author":"Wen","year":"2013","journal-title":"Cardiovasc Diabetol"},{"key":"2021033116162048600_cit0014","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3389\/fphys.2018.01514","article-title":"Diabetic cardiomyopathy: current and future therapies. Beyond glycemic control","volume":"9","author":"Borghetti","year":"2018","journal-title":"Front Physiol"},{"issue":"3","key":"2021033116162048600_cit0015","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1536\/ihj.18-476","article-title":"Current status and challenges of NRF2 as a potential therapeutic target for diabetic cardiomyopathy","volume":"60","author":"Ge","year":"2019","journal-title":"Int Heart J"},{"issue":"8","key":"2021033116162048600_cit0016","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/10408390601062054","article-title":"Black pepper and its pungent principle-piperine: a review of diverse physiological effects","volume":"47","author":"Srinivasan","year":"2007","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"6","key":"2021033116162048600_cit0017","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/1099-0461(2000)14:6<329::AID-JBT5>3.0.CO;2-G","article-title":"Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats","volume":"14","author":"Rauscher","year":"2000","journal-title":"J Biochem Mol Toxicol"},{"issue":"2","key":"2021033116162048600_cit0018","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1139\/H09-133","article-title":"Gastrointestinal protective effect of dietary spices during ethanol-induced oxidant stress in experimental rats","volume":"35","author":"Prakash","year":"2010","journal-title":"Appl Physiol Nutr Metab"},{"issue":"5","key":"2021033116162048600_cit0019","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/19336950.2015.1092836","article-title":"Anticonvulsant mechanisms of piperine, a piperidine alkaloid","volume":"9","author":"Mishra","year":"2015","journal-title":"Channels"},{"issue":"1","key":"2021033116162048600_cit0020","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0278-6915(02)00216-8","article-title":"Antimutagenic properties of bell and black peppers","volume":"41","author":"El Hamss","year":"2003","journal-title":"Food Chem Toxicol"},{"issue":"6","key":"2021033116162048600_cit0021","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.bmcl.2008.01.101","article-title":"Protective effects of amide constituents from the fruit of Piper chaba on d-galactosamine\/TNF-\u03b1-induced cell death in mouse hepatocytes","volume":"18","author":"Matsuda","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"issue":"8","key":"2021033116162048600_cit0022","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/ptr.4972","article-title":"Piper nigrum and piperine: an update","volume":"27","author":"Meghwal","year":"2013","journal-title":"Phytother Res"},{"issue":"1\u20133","key":"2021033116162048600_cit0023","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ejphar.2010.05.026","article-title":"Inhibition of lipopolysaccharide-induced inflammatory responses by piperine","volume":"642","author":"Bae","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"2021033116162048600_cit0024","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3389\/fphar.2016.00390","article-title":"Piperine suppresses pyroptosis and interleukin-1\u03b2 release upon ATP triggering and bacterial infection","volume":"7","author":"Liang","year":"2016","journal-title":"Front Pharmacol"},{"key":"2021033116162048600_cit0025","doi-asserted-by":"crossref","first-page":"2601408","DOI":"10.1155\/2019\/2601408","article-title":"Piperine alleviates doxorubicin-induced cardiotoxicity via activating PPAR-gamma in mice","volume":"2019","author":"Yan","year":"2019","journal-title":"PPAR Res"},{"issue":"6","key":"2021033116162048600_cit0026","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s10072-010-0243-3","article-title":"Minocycline with aspirin: a therapeutic approach in the treatment of diabetic neuropathy","volume":"31","author":"Bhatt","year":"2010","journal-title":"Neurol Sci"},{"issue":"5","key":"2021033116162048600_cit0027","first-page":"965","article-title":"Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice","volume":"69","author":"Atal","year":"2012","journal-title":"Acta Pol Pharm"},{"issue":"6","key":"2021033116162048600_cit0028","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/fcp.12003","article-title":"Elucidation of molecular mechanism involved in neuroprotective effect of C oenzyme Q 10 in alcohol-induced neuropathic pain","volume":"27","author":"Kandhare","year":"2013","journal-title":"Fundam Clin Pharmacol"},{"issue":"4","key":"2021033116162048600_cit0029","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.biomag.2012.10.006","article-title":"elucidation of ameliorative effect of Co-enzyme Q10 in streptozotocin-induced diabetic neuropathic perturbation by modulation of electrophysiological, biochemical and behavioral markers","volume":"2","author":"Visnagri","year":"2012","journal-title":"Biomed Aging Pathol"},{"issue":"3","key":"2021033116162048600_cit0030","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.imr.2015.02.003","article-title":"Alleviating exercise-induced muscular stress using neat and processed bee pollen: oxidative markers, mitochondrial enzymes, and myostatin expression in rats","volume":"4","author":"Ketkar","year":"2015","journal-title":"Integr Med Res"},{"issue":"4","key":"2021033116162048600_cit0031","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/archgenpsychiatry.2010.22","article-title":"Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder","volume":"67","author":"Andreazza","year":"2010","journal-title":"Arch Gen Psychiatry"},{"issue":"3","key":"2021033116162048600_cit0032","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3109\/0886022X.2014.996843","article-title":"Renoprotective effect of berberine via intonation on apoptosis and mitochondrial-dependent pathway in renal ischemia reperfusion-induced mutilation","volume":"37","author":"Visnagri","year":"2015","journal-title":"Ren Fail"},{"key":"2021033116162048600_cit0033","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cbi.2014.05.012","article-title":"Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats","volume":"219","author":"Kandhare","year":"2014","journal-title":"Chem Biol Interact"},{"issue":"2","key":"2021033116162048600_cit0034","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1538\/expanim.14-0084","article-title":"Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin","volume":"64","author":"Katsuda","year":"2015","journal-title":"Exp Anim"},{"issue":"1\u20132","key":"2021033116162048600_cit0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000064682","article-title":"Left ventricular diastolic dysfunction as an early manifestation of diabetic cardiomyopathy","volume":"98","author":"Schannwell","year":"2002","journal-title":"Cardiology"},{"issue":"4","key":"2021033116162048600_cit0036","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbrc.2004.04.138","article-title":"Streptozotocin directly impairs cardiac contractile function in isolated ventricular myocytes via a p38 map kinase-dependent oxidative stress mechanism","volume":"318","author":"Wold","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"2021033116162048600_cit0037","doi-asserted-by":"crossref","first-page":"H927","DOI":"10.1152\/ajpheart.00049.2016","article-title":"Diastolic dysfunction in prediabetic male rats: role of mitochondrial oxidative stress","volume":"311","author":"Koncsos","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"25","key":"2021033116162048600_cit0038","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1161\/CIRCULATIONAHA.106.679597","article-title":"Diabetic cardiomyopathy revisited","volume":"115","author":"Boudina","year":"2007","journal-title":"CIRC J"},{"issue":"3","key":"2021033116162048600_cit0039","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1139\/Y10-016","article-title":"Oxidative stress: a key contributor to diabetic cardiomyopathy","volume":"88","author":"Khullar","year":"2010","journal-title":"Can J Physiol Pharmacol"},{"issue":"1","key":"2021033116162048600_cit0040","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neulet.2012.01.019","article-title":"Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals","volume":"511","author":"Kandhare","year":"2012","journal-title":"Neurosci Lett"},{"issue":"7","key":"2021033116162048600_cit0041","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1253\/circj.CJ-10-1199","article-title":"Overexpression of human C-reactive protein exacerbates left ventricular remodeling in diabetic cardiomyopathy","volume":"75","author":"Mano","year":"2011","journal-title":"Circ J"},{"issue":"6","key":"2021033116162048600_cit0042","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/sj.bjp.0706245","article-title":"Pomegranate flower improves cardiac lipid metabolism in a diabetic rat model: role of lowering circulating lipids","volume":"145","author":"Huang","year":"2005","journal-title":"Br J Pharmacol"},{"issue":"2","key":"2021033116162048600_cit0043","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1258\/002367706776319042","article-title":"Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals","volume":"40","author":"O\u2019brien","year":"2006","journal-title":"Lab Anim"},{"issue":"BIC","key":"2021033116162048600_cit0044","doi-asserted-by":"crossref","first-page":"S31798","DOI":"10.4137\/BIC.S31798","article-title":"The role of biomarkers in decreasing risk of cardiac toxicity after cancer therapy: supplementary issue: biomarkers and their essential role in the development of personalised therapies (A)","volume":"8","author":"Henri","year":"2016","journal-title":"Cancer Biomark"},{"issue":"2","key":"2021033116162048600_cit0045","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cardiores.2005.10.001","article-title":"The role of natriuretic peptides in cardioprotection","volume":"69","author":"Nishikimi","year":"2006","journal-title":"Cardiovasc Res"},{"issue":"5","key":"2021033116162048600_cit0046","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1161\/01.HYP.0000144801.09557.4c","article-title":"Atrial natriuretic peptide dose-dependently inhibits pressure overload-induced cardiac remodeling","volume":"44","author":"Franco","year":"2004","journal-title":"Hypertension"},{"issue":"8","key":"2021033116162048600_cit0047","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1111\/bph.12475","article-title":"Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy","volume":"171","author":"Fillmore","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"1","key":"2021033116162048600_cit0048","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1744-9987.2006.00343.x","article-title":"Effects of immunoadsorption on the nt-BNP and nt-ANP plasma levels of patients suffering from dilated cardiomyopathy","volume":"10","author":"Staudt","year":"2006","journal-title":"Ther Apheresis Dialysis"},{"issue":"1","key":"2021033116162048600_cit0049","doi-asserted-by":"crossref","first-page":"e54620","DOI":"10.1371\/journal.pone.0054620","article-title":"Large domain motions in Ago protein controlled by the guide DNA-strand seed region determine the Ago-DNA-mRNA complex recognition process","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"2021033116162048600_cit0050","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00432-014-1854-5","article-title":"Expression and clinicopathological significance of EED, SUZ12 and EZH2 mRNA in colorectal cancer","volume":"141","author":"Liu","year":"2015","journal-title":"J Cancer Res Clin Oncol"},{"key":"2021033116162048600_cit0051","first-page":"154","article-title":"Induction of apoptosis by piperine in human cervical adenocarcinoma via ROS mediated mitochondrial pathway and caspase-3 activation","volume":"18","author":"Jafri","year":"2019","journal-title":"Excli J"},{"issue":"2","key":"2021033116162048600_cit0052","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.taap.2010.02.002","article-title":"Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver","volume":"245","author":"Patel","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"issue":"5","key":"2021033116162048600_cit0053","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1139\/bcb-2014-0107","article-title":"Berberine as a therapy for type 2 diabetes and its complications: from mechanism of action to clinical studies","volume":"93","author":"Chang","year":"2015","journal-title":"Biochem Cell Biol"},{"issue":"8","key":"2021033116162048600_cit0054","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1021\/cr900211p","article-title":"Marine indole alkaloids: potential new drug leads for the control of depression and anxiety","volume":"110","author":"Kochanowska-Karamyan","year":"2010","journal-title":"Chem Rev"}],"container-title":["Bioscience, Biotechnology, and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bbb\/article-pdf\/84\/12\/2533\/36835175\/bbb2533.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bbb\/article-pdf\/84\/12\/2533\/36835175\/bbb2533.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T11:49:51Z","timestamp":1654602591000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bbb\/article\/84\/12\/2533\/6044123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":54,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,1]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1080\/09168451.2020.1815170","relation":{},"ISSN":["1347-6947","0916-8451"],"issn-type":[{"value":"1347-6947","type":"electronic"},{"value":"0916-8451","type":"print"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbbb20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tbbb20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}