{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:38:26Z","timestamp":1778866706592,"version":"3.51.4"},"reference-count":27,"publisher":"Portico","issue":"1-2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Morphology"],"published-print":{"date-parts":[[2005,4,1]]},"DOI":"10.1080\/09243860500095463","type":"journal-article","created":{"date-parts":[[2005,9,7]],"date-time":"2005-09-07T17:29:56Z","timestamp":1126114196000},"page":"31-41","source":"Crossref","is-referenced-by-count":28,"title":["In vivo fatigue microcracks in human bone: Material properties of the surrounding bone matrix"],"prefix":"10.3730","volume":"42","author":[{"given":"Zioupos","family":"P","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1320","reference":[{"key":"E00001","doi-asserted-by":"crossref","unstructured":"Akkus, O, Polyakova-Akkus, A, Adar, F, Schaffler, MB. Aging of microstructural compartments in human compact bone J Bone Miner Res, 2003; 18: 1012\u200a\u2013\u200a1019","DOI":"10.1359\/jbmr.2003.18.6.1012"},{"key":"E00002","doi-asserted-by":"crossref","unstructured":"Briscoe, BJ, Fiori, L, Pelillo, E. Nano-indentation of polymeric surfaces J Physics D, 1998; 31: 2395\u200a\u2013\u200a2405","DOI":"10.1088\/0022-3727\/31\/19\/006"},{"key":"E00003","doi-asserted-by":"crossref","unstructured":"Zioupos, P. Ageing human bone: factors affecting its biomechanical properties and the role of collagen J Biomater Appl, 2001b; 15: 187\u200a\u2013\u200a229","DOI":"10.1106\/5JUJ-TFJ3-JVVA-3RJ0"},{"key":"E00004","doi-asserted-by":"crossref","unstructured":"Burr, DB, Martin, RB, Schaffler, MB, Radin, EL. Bone remodelling in response to in vivo fatigue microdamage J Biomech, 1985; 18: 189\u200a\u2013\u200a200","DOI":"10.1016\/0021-9290(85)90204-0"},{"key":"E00005","doi-asserted-by":"crossref","unstructured":"Burr, DB, Hooser, M. Alterations to the en bloc basic fuchsin staining protocol for the demonstration of microdamage produced in vivo Bone, 1997; 17: 431\u200a\u2013\u200a433","DOI":"10.1016\/S8756-3282(95)00241-3"},{"key":"E00006","doi-asserted-by":"crossref","unstructured":"Burr, DB, Forwood, MR, Fyhrie, DP, Martin, RB, Schaffler, MB, Turner, CH. Bone microdamage and skeletal fragility in osteoporotic and stress fractures J Bone Miner Res, 1997; 12: 6\u200a\u2013\u200a15","DOI":"10.1359\/jbmr.1997.12.1.6"},{"key":"E00007","doi-asserted-by":"crossref","unstructured":"Burr, DB. The contribution of the organic matrix to bone's material properties Bone, 2002; 31: 8\u200a\u2013\u200a11","DOI":"10.1016\/S8756-3282(02)00815-3"},{"key":"E00008","doi-asserted-by":"crossref","unstructured":"Carter, DR, Hayes, WC. Bone compressive strength: the influence of density and strain rate Science, 1976; 194: 1174\u200a\u2013\u200a1176","DOI":"10.1126\/science.996549"},{"key":"E00009","doi-asserted-by":"crossref","unstructured":"Currey, JD. The mechanical consequences of variation in the mineral content of bone J Biomech, 1969; 2: 477\u200a\u2013\u200a480","DOI":"10.1016\/0021-9290(69)90023-2"},{"key":"E00010","doi-asserted-by":"crossref","unstructured":"Currey, JD. Mechanical properties of bone with greatly differing functions J Biomech, 1979; 12: 313\u200a\u2013\u200a319","DOI":"10.1016\/0021-9290(79)90073-3"},{"key":"E00011","doi-asserted-by":"crossref","unstructured":"Donahue, SW, Sharkey, NA, Modanlou, KA, Sequeira, LN, Martin, RB. Bone strain and micro cracks at stress fracture sites in human metatarsals Bone, 2000; 27: 827\u200a\u2013\u200a833","DOI":"10.1016\/S8756-3282(00)00402-6"},{"key":"E00012","doi-asserted-by":"crossref","unstructured":"Fan, ZF, Rho, JY. Effects of viscoelasticity and time-dependent plasticity on nanoindentation measurements of human cortical bone J Biomed Mater Res, 2003; 67: 208\u200a\u2013\u200a214","DOI":"10.1002\/jbm.a.10027"},{"key":"E00013","doi-asserted-by":"crossref","unstructured":"Frank, JD, Ryan, M, Kalscheur, VL, Ruaux-Mason, CP, Hoazak, RR, Muir, P. Aging and accumulation of microdamage in canine bone Bone, 2002; 30: 201\u200a\u2013\u200a206","DOI":"10.1016\/S8756-3282(01)00623-8"},{"key":"E00014","doi-asserted-by":"crossref","unstructured":"Frost, HM. Presence of microscopic cracks in vivo in bone Henry Ford Hosp Bull, 1960; 8: 27\u200a\u2013\u200a35","DOI":"10.3109\/10520296009114729"},{"key":"E00015","doi-asserted-by":"crossref","unstructured":"Grynpas, M. Age- and disease-related changes in the mineral of bone Calcif Tissue Int, 1993; 53: S57\u200a\u2013\u200a64","DOI":"10.1007\/BF01673403"},{"key":"E00016","doi-asserted-by":"crossref","unstructured":"Mori, S, Burr, DB. Increased intracortical remodelling following fatigue microdamage Bone, 1993; 14: 103\u200a\u2013\u200a109","DOI":"10.1016\/8756-3282(93)90235-3"},{"key":"E00017","doi-asserted-by":"crossref","unstructured":"Mori, S, Harruff, R, Ambrosius, W, Burr, DB. Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures Bone, 1997; 21: 521\u200a\u2013\u200a526","DOI":"10.1016\/S8756-3282(97)00200-7"},{"key":"E00018","doi-asserted-by":"crossref","unstructured":"Norman, TL, Wang, Z. Microdamage of human cortical bone: Incidence and morphology in long bones Bone, 1997; 20: 375\u200a\u2013\u200a379","DOI":"10.1016\/S8756-3282(97)00004-5"},{"key":"E00019","doi-asserted-by":"crossref","unstructured":"Norman, TL, Yeni, YN, Brown, CU, Wang, Z. Influence of microdamage on fracture toughness of the femur and tibia Bone, 1998; 23: 303\u200a\u2013\u200a306","DOI":"10.1016\/S8756-3282(98)00103-3"},{"key":"E00020","doi-asserted-by":"crossref","unstructured":"Oliver, WC, Pharr, GM. An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments J Mater Res, 1992; 7: 1564\u200a\u2013\u200a1583","DOI":"10.1557\/JMR.1992.1564"},{"key":"E00021","doi-asserted-by":"crossref","unstructured":"Parfitt, AM. Bone age, mineral density, and fatigue damage Calcif Tissue Int, 1993; 53: S82\u200a\u2013\u200a86","DOI":"10.1007\/BF01673408"},{"key":"E00022","doi-asserted-by":"crossref","unstructured":"Schaffler, MB, Choi, K, Milgrom, C. Aging and matrix microdamage accumulation in human compact bone Bone, 1995; 17: 521\u200a\u2013\u200a525","DOI":"10.1016\/8756-3282(95)00370-3"},{"key":"E00023","doi-asserted-by":"crossref","unstructured":"Timlin, JA, Carden, A, Morris, MD. Raman spectroscopic imaging markers for fatigue-related microdamage in bovine bone Anal Chem, 2000; 72: 2229\u200a\u2013\u200a2236","DOI":"10.1021\/ac9913560"},{"key":"E00024","doi-asserted-by":"crossref","unstructured":"Vashishth, D, Verborgt, O, Divine, G, Schaffler, MB, Fyhrie, DP. Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age Bone, 2000; 26: 375\u200a\u2013\u200a380","DOI":"10.1016\/S8756-3282(00)00236-2"},{"key":"E00025","doi-asserted-by":"crossref","unstructured":"Zioupos, P. Recent developments in the study of failure of solid biomaterials and bone: \u2018fracture\u2019 and \u2018pre-fracture\u2019 toughness Mater Sci Eng C, 1998; 6: 33\u200a\u2013\u200a40","DOI":"10.1016\/S0928-4931(98)00033-2"},{"key":"E00026","doi-asserted-by":"crossref","unstructured":"Zioupos, P, Currey, JD, Casinos, A. Exploring the effects of hypermineralisation in bone tissue by using an extreme biological example Connect Tissue Res, 2000; 41: 229\u200a\u2013\u200a248","DOI":"10.3109\/03008200009005292"},{"key":"E00027","doi-asserted-by":"crossref","unstructured":"Zioupos, P. Accumulation of in vivo fatigue microdamage and its relation to biomechanical properties in ageing human cortical bone J Microsc, 2001a; 201: 270\u200a\u2013\u200a278","DOI":"10.1046\/j.1365-2818.2001.00783.x"}],"container-title":["European Journal of Morphology"],"original-title":[],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T11:16:31Z","timestamp":1683198991000},"score":1,"resource":{"primary":{"URL":"http:\/\/access.portico.org\/stable?au=pggtrn2cqj"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,1]]},"references-count":27,"aliases":["10.1080\/ejom.42.1-2.0031"],"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2005,4,1]]}},"alternative-id":["Q3587213QN373847"],"URL":"https:\/\/doi.org\/10.1080\/09243860500095463","relation":{},"ISSN":["0924-3860"],"issn-type":[{"value":"0924-3860","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4,1]]}}}