{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:06:13Z","timestamp":1770897973457,"version":"3.50.1"},"reference-count":38,"publisher":"Informa UK Limited","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Biology"],"published-print":{"date-parts":[[2003,6]]},"DOI":"10.1080\/0955300031000139371","type":"journal-article","created":{"date-parts":[[2004,1,24]],"date-time":"2004-01-24T16:31:26Z","timestamp":1074961886000},"page":"423-430","source":"Crossref","is-referenced-by-count":11,"title":["Genetic susceptibility to thymic lymphomas and K\u2010\n                    <i>ras<\/i>\n                    gene mutation in mice after exposure to X\u2010rays and\n                    <i>N<\/i>\n                    \u2010ethyl\u2010\n                    <i>N<\/i>\n                    \u2010nitrosourea"],"prefix":"10.1080","volume":"79","author":[{"given":"Y.","family":"Shimada","sequence":"first","affiliation":[{"name":"Low Dose Radiation Effect Project, National Institute of Radiological Sciences, Inage\u2010ku, Chiba 263\u20108555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Environmental Radiation Protection Research Group, National Institute of Radiological Sciences, Chiba 263\u20108555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kakinuma","sequence":"additional","affiliation":[{"name":"Laboratory of Radiation Life Science, Kyoto University, Osaka 590\u20100494, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ogiu","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Science, Faculty of Science, Toho University, Chiba 274\u20108510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kubo","sequence":"additional","affiliation":[{"name":"Low Dose Radiation Effect Project, National Institute of Radiological Sciences, Inage\u2010ku, Chiba 263\u20108555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Nagai","sequence":"additional","affiliation":[{"name":"Environmental Radiation Protection Research Group, National Institute of Radiological Sciences, Chiba 263\u20108555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kobayash","sequence":"additional","affiliation":[{"name":"Laboratory of Radiation Life Science, Kyoto University, Osaka 590\u20100494, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Tano","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Science, Faculty of Science, Toho University, Chiba 274\u20108510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yoshinaga","sequence":"additional","affiliation":[{"name":"Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. K.","family":"Bhakat","sequence":"additional","affiliation":[{"name":"Low Dose Radiation Effect Project, National Institute of Radiological Sciences, Inage\u2010ku, Chiba 263\u20108555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2009,7,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"2008","article-title":"Efficient repair of 06-ethylguanine, but not 04-ethylthymine or 02-ethylthymine, is dependent upon 06-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells","volume":"52","author":"BRONSTEIN S. M.","year":"1992","unstructured":"BRONSTEIN, S. M., SKOPEK, T. R. and SWENBERG, J. A., 1992, Efficient repair of 06-ethylguanine, but not 04-ethylthymine or 02-ethylthymine, is dependent upon 06-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells. Cancer Research, 52, 2008\u20132011.","journal-title":"Cancer Research"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","unstructured":"BUCHMANN A. BAUER-HOFMANN R. MAUR J. DRINKWATER N. R. Luz A. and SCHWARZ M. 1991 Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcino-genesis. Proceedings of National Academy of Sciences USA 88 911\u2013915.","DOI":"10.1073\/pnas.88.3.911"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.919341"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/095530099139377"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199902000-00011"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.8.5.2233-2236.1988"},{"key":"e_1_2_1_8_1","first-page":"333","article-title":"Incidence of mutations at codon 61 of the Ha-ras gene in liver tumors of mice genetically susceptible and resistant to hepatocarcinogenesis","volume":"6","author":"DRAGANI T. A.","year":"1991","unstructured":"DRAGANI, T. A., MANENTI, G., COLOM BO, B. M., FALVELLA, F. S., GARIBOLDI, M., PIEROTII, M. A. and DELLA PORTA, G., 1991, Incidence of mutations at codon 61 of the Ha-ras gene in liver tumors of mice genetically susceptible and resistant to hepatocarcinogenesis. Oncogene, 6, 333\u2013338.","journal-title":"Oncogene"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60711-3"},{"key":"e_1_2_1_10_1","first-page":"845","article-title":"Thymomas induced by simple alkylating agents in C57BL\/Cbi mice: kinetics of the dose response","volume":"64","author":"FREI J. V.","year":"1980","unstructured":"FREI, J. V. and LAWLEY, P. D., 1980, Thymomas induced by simple alkylating agents in C57BL\/Cbi mice: kinetics of the dose response. Journal of the National Cancer Institute, 64, 845\u2013856.","journal-title":"Journal of the National Cancer Institute"},{"key":"e_1_2_1_11_1","first-page":"4818","article-title":"Activation of K-ras by codon 13 mutations in C57BL\/6 X C3H Fl mouse tumors induced by exposure to 1,3-butadiene","volume":"50","author":"GOODROW T.","year":"1990","unstructured":"GOODROW, T., REYNOLDS, S., MARONPOT, R. and ANDERSON, M., 1990, Activation of K-ras by codon 13 mutations in C57BL\/6 X C3H Fl mouse tumors induced by exposure to 1,3-butadiene. Cancer Research, 50, 4818\u20134823.","journal-title":"Cancer Research"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6474169"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","unstructured":"JACKSON P. E. HALL C. N. O'CONNOR P. J. COOPER D. P. MARGISON G. P. and POVEY A. C. 1997 Low 06-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC \u2014> AT transition in the K-ras oncogene. Carcinogenesis 18 1299\u20131302.","DOI":"10.1093\/carcin\/18.7.1299"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/095530097143419"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553000050111578"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/85798"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","unstructured":"MALUMBRES M. PEREZ DE CASTRO I. SANTOS J. MELENDEZ B. MANGUES R. SERRANO M. PELLICER A. and FERNANDEZ-PIQUERAS J. 1997 Inactivation of the cyclin-dependent kinase inhibitor p 15INK4b by deletion and de novo methylation with independence of pl6INK4a alterations in murine primary T-cell lymphomas. Oncogene 14 1361\u20131370.","DOI":"10.1038\/sj.onc.1200969"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(95)03112-S"},{"key":"e_1_2_1_19_1","first-page":"115","article-title":"Identification of a specific marker chromosome early in tumor development in gamma-irradiated C57BL\/6J mice","volume":"2","author":"MCMORROW L. E.","year":"1988","unstructured":"MCMORROW, L. E., NEwcomB, E. W. and PELLICER, A., 1988, Identification of a specific marker chromosome early in tumor development in gamma-irradiated C57BL\/6J mice. Leukemia, 2, 115\u2013119.","journal-title":"Leukemia"},{"key":"e_1_2_1_20_1","first-page":"1","article-title":"The structure of mutation in mammalian cells","volume":"1032","author":"MEUTH M","year":"1990","unstructured":"MEUTH, M., 1990, The structure of mutation in mammalian cells. Biochimica et Biophysica Acta, 1032, 1\u201317.","journal-title":"Biochimica et Biophysica Acta"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204497"},{"key":"e_1_2_1_22_1","first-page":"5514","article-title":"ras oncogenes and phenotypic staging in JV:methylnitrosourea-and gamma-irradiation-induced thymic lymphomas in C57BL\/6J mice","volume":"48","author":"NEWCOMB E. W.","year":"1988","unstructured":"NEWCOMB, E. W., STEINBERG, J. J. and PELLICER, A., 1988, ras oncogenes and phenotypic staging in JV:methylnitrosourea-and gamma-irradiation-induced thymic lymphomas in C57BL\/6J mice. Cancer Research, 48, 5514\u20135521.","journal-title":"Cancer Research"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0921-8777(01)00098-2"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.2307\/3579764"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","unstructured":"OKANO H. SAITO Y. MIYAZAWA T. SHINBO T. CHOU D. KOSUGI S. TAxAHAsm Y. ODANI S. NIWA 0. and KOMINAMI R. 1999 Homozygous deletions and point mutations of the Ikaros gene in gamma-ray-induced mouse thymic lymphomas. Oncogene 18 6677\u20136683.","DOI":"10.1038\/sj.onc.1203100"},{"key":"e_1_2_1_26_1","first-page":"3848","article-title":"Genetic analysis of resistance to radiation lymphoma-genesis with recombinant inbred strains of mice","volume":"50","author":"OKUMOTO M.","year":"1990","unstructured":"OKUMOTO, M., NISHIKAWA, R., Imm, S. and ILLGERs, J., 1990, Genetic analysis of resistance to radiation lymphoma-genesis with recombinant inbred strains of mice. Cancer Research, 50, 3848\u20133850.","journal-title":"Cancer Research"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(00)00017-X"},{"key":"e_1_2_1_28_1","first-page":"1068","article-title":"Environment and cancer","volume":"278","author":"PERERA F. P","year":"1997","unstructured":"PERERA, F. P., 1997, Environment and cancer: who are susceptible? Science, 278, 1068\u20131073.","journal-title":"who are susceptible? Science"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(90)90181-5"},{"key":"e_1_2_1_30_1","first-page":"2415","article-title":"Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice","volume":"57","author":"SAKUMI K.","year":"1997","unstructured":"SAKUMI, K., SHERAISHI, A., SHIMIZU, S., TSUZUKI, T., ISHIKAWA, T. and SEKIGUCHI, M., 1997, Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice. Cancer Research, 57, 2415\u20132418.","journal-title":"Cancer Research"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(91)90029-U"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(99)00100-1"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.2307\/3579149"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(93)90005-8"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2000)154[0293:RALOHA]2.0.CO;2"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553000010022643"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.10.1.405-408.1990"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","unstructured":"STORER \" B. MITCHELL T. J. and FRY R. J. 1988 Extrapolation of the relative risk of racliogenic neoplasms across mouse strains and to man. Radiation Research 114 331\u2013353.","DOI":"10.2307\/3577229"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-035416-0.50008-2"}],"container-title":["International Journal of Radiation Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/0955300031000139371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:05:10Z","timestamp":1770894310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/0955300031000139371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.1080\/0955300031000139371"],"URL":"https:\/\/doi.org\/10.1080\/0955300031000139371","relation":{},"ISSN":["0955-3002","1362-3095"],"issn-type":[{"value":"0955-3002","type":"print"},{"value":"1362-3095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}