{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:05:50Z","timestamp":1772769950864,"version":"3.50.1"},"reference-count":60,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Biology"],"published-print":{"date-parts":[[1996,1]]},"DOI":"10.1080\/095530096145940","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T12:22:42Z","timestamp":1027686162000},"page":"385-395","source":"Crossref","is-referenced-by-count":8,"title":["Genetic complementation of radiation response by 3 untranslated regions (UTR) of RNA"],"prefix":"10.1080","volume":"69","author":[{"given":"P.","family":"CHEN","sequence":"first","affiliation":[{"name":"Department of Molecular and Medical Genetics, University of Toronto; Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada"}]}],"member":"301","published-online":{"date-parts":[[2009,7,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","unstructured":"AKASHI M. SHAW G. GROSS M. SAITO M. and KOEFFLER H. P. 1991 Role of AUUU sequences in stabilization of granulocyte-macrophage colony-stimulating factor RNA in stimulated cells. Blood 78 2005\u20132012.","DOI":"10.1182\/blood.V78.8.2005.2005"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553009414550211"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(89)90515-5"},{"key":"e_1_2_1_5_1","first-page":"6426","article-title":"Hetero-geneous DNA damage and repair in the mammalian genome","volume":"47","author":"BOHR V. A.","year":"1987","unstructured":"BOHR, V. A., PHILLIPS, D. H. and HANAWALT, P. C., 1987, Hetero-geneous DNA damage and repair in the mammalian genome. Cancer Research, 47, 6426\u20136436.","journal-title":"Cancer Research"},{"key":"e_1_2_1_6_1","first-page":"5587","article-title":"Induction of tissue-type plasminogen activator by ionising radiation in human malignant melanoma cells","volume":"51","author":"BOOTHMAN D. A.","year":"1991","unstructured":"BOOTHMAN, D. A., WANG, M. and LEE, S. W., 1991, Induction of tissue-type plasminogen activator by ionising radiation in human malignant melanoma cells. Cancer Research, 51, 5587\u20135595.","journal-title":"Cancer Research"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","unstructured":"CAPuT D. BEGTLER B. HARTOG K. THAYE RR. BROWN-SHImER S. and CERAMI A. 1986 Identification of a common nucleotide sequence in the 3 -untranslated region of mRNA molecules specifying inflammatory mediators. Proceedings of the National Academy of Sciences USA 83 1670\u20131674.","DOI":"10.1073\/pnas.83.6.1670"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb08544.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","unstructured":"CHEN C. -Y A. and SHYU A. 1994 Selective degradation of early-response-gene mRNAs: function analysis of sequence features of the AU-rich elements. Molecular and Cellular Biology 14 8471\u20138482.","DOI":"10.1128\/mcb.14.12.8471-8482.1994"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(94)90069-8"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(84)90149-0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/274484a0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.13.6127"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(84)90038-1"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.26.120192.002451"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2787(77)90253-2"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","unstructured":"GooDwIN E. B. OKKEMA P. G. EVANS T. C. and K!mBLE J. 1993 Translational regulation of tra-2 by its 3 untranslated region controls sexual identity in C. elegans. Cell 75 329\u2013339.","DOI":"10.1016\/0092-8674(93)80074-O"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1967.02090270073006"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","unstructured":"GREEN M. H. LowE J. E. ARLETT C. F. HARCOURT S. A. BURKE J. F. JAMES M. R. and LEHMANN A. R. 1987 A gamma-ray resistant derivative of an ataxia-telangiectasia cell line following DNA-mediated gene transfer. Journal of Cell Science 6 (suppl.) 127\u2013137.","DOI":"10.1242\/jcs.1984.Supplement_6.8"},{"key":"e_1_2_1_20_1","author":"GREENBERG M. E.","year":"1993","unstructured":"GREENBERG, M. E. and BELASCO, J. G., 1993, Control of the decay of labile proto oncogene and cytokine mRNAs. In J. Belasco and G. Brawerman (ed.), Control of Messenger RNA stability. (Academic, San Diego), pp. 199-218.","journal-title":"Control of the decay of labile proto oncogene and cytokine mRNAs"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","unstructured":"HALLAHAN D. E. SGKHATME V. P. SHERMAN M. L. VIRUDACHA-LAM S. KGFE D. and WEICHSELBAGM R. R. 1991 Protein kinase C mediates X-ray inducibility of nuclear signal transducers EGR1 and JUN. Proceedings of the National Academy of Sciences USA 88 2156\u20132160.","DOI":"10.1073\/pnas.88.6.2156"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.10.3045"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.2307\/3578563"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/8.16.3709"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","unstructured":"JASPERS N. G. J. and BOOTSMA D. 1982 Genetic heterogeneity in ataxia-telangiectasia studied by cell fusion. Proceed-ings of the National Academy of Sciences USA 79 2641\u20132644.","DOI":"10.1073\/pnas.79.8.2641"},{"key":"e_1_2_1_26_1","unstructured":"KASTAN M. B. ONYEKWERE 0. SIDRANSKY D. VOGELSTEIN B. and CRAIG R. W. 1991 Participation of p53 protein in the cellular response of DNA damage. Cancer Research 51 6304\u20136311."},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","unstructured":"KASTAN M. B. ZHAN 0. EI-DEIRY W. S. CARRIER F. JACKS T. WALSH W. V. PLUNKETT B. S. VOGELSTEIN B. and FOR-NACE A. J. 1992 A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71 587\u2013597.","DOI":"10.1016\/0092-8674(92)90593-2"},{"key":"e_1_2_1_28_1","first-page":"3307","article-title":"Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia","volume":"8","author":"KHANNA K. K.","year":"1993","unstructured":"KHANNA, K. K. and LAVIN, M. F., 1993, Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia. Oncogene, 8, 3307\u20133312.","journal-title":"Oncogene"},{"key":"e_1_2_1_29_1","unstructured":"KMSON C. CHEN P. and ImRAY P. 1982 Ataxia-telangiectasia heterozygotes: dominant expresion of ionising radia-tion sensitive mutant In: Ataxia-telangiectasia\u2014 A Cellu-lar and Molecular Link Between Cancer Neuropathology and Immune Deficiency. Edited by: B. A. Bridges and D. G. Harnden (Wiley: Chichester) pp. 363\u2013372."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90046-S"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1993.tb01692.x"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","unstructured":"KRAMER M. STEIN B. MAI S. KUNZ E. KOINIG H. LOFERER H. GRUNICKE H. H. PONTA H. HERRLICH P. and KAHMS-DORF H. J. 1990 Radiation-induced activation of tran-scription factors in mammalian cells. Radiation Environmental Biophysics 29 303\u2013313.","DOI":"10.1007\/BF01210410"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","unstructured":"LAGNADO C. A. BROWN C. Y. and GOODALL 1994 AUUUAis not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA (U\/A) (U\/A). Molecular and Cellular Biology 14 7984\u20137995.","DOI":"10.1128\/mcb.14.12.7984-7995.1994"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90529-Y"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/359070a0"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.13.6.3494-3504.1993"},{"key":"e_1_2_1_37_1","unstructured":"MEYN M. S. Lu-Kuo J. M. and HERZING L. B. K. 1993 Expression cloning of multiple human cDNAs that complement the phenotypic defects of ataxia-tel-angiectasia group D fibroblasts. American Journal of Human Genetics 53 1206\u20131216."},{"key":"e_1_2_1_38_1","first-page":"557","article-title":"Radiation reaction in ataxia-telangiectasia","volume":"116","author":"MORGAN J. L.","year":"1968","unstructured":"MORGAN, J. L., HOLCOMB, T. M. and MORRISSEY, R. W., 1968, Radiation reaction in ataxia-telangiectasia. American Journal of Diseases of Childhood, 116, 557\u2013558.","journal-title":"American Journal of Diseases of Childhood"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.1960"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.14.7.4920-4928.1994"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1411571"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7508142"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8817(85)90041-0"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7315"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.13.120179.001451"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90579-F"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90320-P"},{"key":"e_1_2_1_48_1","doi-asserted-by":"crossref","unstructured":"SAVITSKY K. BAR-SHIRA A. GILAD S. ROTMAN G. ZIV Y VANAGAITE L. TAGLE D. A. et al. 1995 A single ataxia-telangiectasia gene with a product similar to PI-3 kinase. Science 268 1749\u20131753.","DOI":"10.1126\/science.7792600"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.10.10.5279-5285.1990"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/356763a0"},{"key":"e_1_2_1_51_1","doi-asserted-by":"crossref","unstructured":"TAYLOR A. M. R. HARNDEN D. G. ARLETT C. F. HARCOURT A. R. LEHMANN A. R. STEVENS S. and BRIDGES B. A. 1975 Ataxia-telangiectasia: a human mutation with abnor-mal radiation sensitivity. Nature 258 427\u2013429.","DOI":"10.1038\/258427a0"},{"key":"e_1_2_1_52_1","first-page":"441","volume":"260","author":"TAYLOR A. M.","year":"1976","unstructured":"TAYLOR, A. M., METCALFE, J. A., OXFORD, J. M. and HARNDEN, D. G., 1976, Is chromatid-type damage in ataxia-telangiectasia after irradiation of Go cells a conse-quence of defective repair? Nature, 260, 441\u2013443.","journal-title":"Is chromatid-type damage in ataxia-telangiectasia after irradiation of Go cells a conse-quence of defective repair? Nature"},{"key":"e_1_2_1_53_1","doi-asserted-by":"crossref","unstructured":"UCKUN F. M. SCHIEVEN G. L. TUEL-AHLGREN L. M. DIBIRDIK I. MYERS D. E. LEDBETTER J. A. and SONG C. W. 1993 Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors. Proceedings of the National Academy of Sciences USA 90 252\u2013256.","DOI":"10.1073\/pnas.90.1.252"},{"key":"e_1_2_1_54_1","doi-asserted-by":"crossref","unstructured":"UENO S. KOTANI y. KONDOH K. SAN? A. KAKIMOTO Y and CAMPAGNONI A. T. 1994a The 3 -untranslated region of mouse myelin basic protein gene increases the amount of mRNA in immortalized mouse oligodendrocytes. Biochemical and Biophysical Research Communications 204 1352\u20131357.","DOI":"10.1006\/bbrc.1994.2612"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.62041254.x"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-035405-4.50011-6"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.2307\/3575500"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/367017a0"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90530-4"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.12.7.2931-2940.1992"},{"key":"e_1_2_1_61_1","doi-asserted-by":"crossref","unstructured":"ZDT Y. BAR-SHIRA A. JORGENSEN T. RUSSELL P. S. SARTIEL A. Snows T. B. EDDY R. L. BUCHWALD M. LEGERSKI R. SCHIMKE R. T. and SHILOH Y. 1995 Human cDNA clones that modify radiomimetic sensitivity of ataxia-telangiectasia (Group A) cells. Somatic Cell and Molecu-lar Genetics 21 99\u2013111.","DOI":"10.1007\/BF02255785"}],"container-title":["International Journal of Radiation Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/095530096145940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:53:49Z","timestamp":1772765629000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/095530096145940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["10.1080\/095530096145940"],"URL":"https:\/\/doi.org\/10.1080\/095530096145940","relation":{},"ISSN":["0955-3002","1362-3095"],"issn-type":[{"value":"0955-3002","type":"print"},{"value":"1362-3095","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1]]}}}