{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:09:46Z","timestamp":1791328186739,"version":"4.3.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>: Beh\u00e7et\u2032s disease (BD) is a systemic immuno\u2010inflammatory disorder and the aetiopathogenesis is to be specified. Cytokines play a role in immune response and in many inflammatory diseases. The aim of this case\u2010control study is to investigate serum pro\u2010inflammatory cytokine tumour necrosis factor (TNF)\u2010\u03b1, interleukin\u20101beta (IL\u20101\u03b2), soluble IL\u20102 receptor (sIL\u20102R), IL\u20106, and chemokine IL\u20108 levels in patients with BD. We also determined the end product of lipid peroxidation (malondialdehyde (MDA)) in BD patients as an index for oxidative stress.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: A total of 37 patients (19 men, 18 women) with BD (active, <jats:italic>n<\/jats:italic> = 17; inactive, <jats:italic>n<\/jats:italic> = 20) and 20 age\u2010matched and sex\u2010matched healthy control subjects (11 men, nine women) included in this cross\u2010sectional, blinded study. Serum TNF\u2010\u03b1, IL\u20101\u03b2, sIL\u20102R, IL\u20106 and IL\u20108 levels were determined by a spectrophotometer technique using the immulite chemiluminescent immunometric assay. Lipid peroxidation was evaluated by Wasowicz <jats:italic>et al<\/jats:italic>. The levels of cytokines and lipid peroxidation in the active period were compared with the inactive period of the disease. Results are expressed as mean \u00b1 standard error.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: IL\u20101\u03b2 levels were below the detection limits of the assay (&lt; 5 pg\/ml) in all samples. Mean levels of MDA (8.1 \u00b1 0.7 \u03bcmol\/l), sIL\u20102R (800 \u00b1 38 U\/ml), IL\u20106 (12.6 \u00b1 1.1 pg\/ml), IL\u20108 (7.2 \u00b1 0.4 pg\/ml), and TNF\u2010\u03b1 (7.9 \u00b1 0.5 pg\/ml) in active BD patients were significantly higher than those in inactive patients (4.3 \u00b1 0.5 \u03bcmol\/l, <jats:italic>p<\/jats:italic> &lt; 0.01; 447 \u00b1 16 U\/ml, <jats:italic>p<\/jats:italic> &lt; 0.001\n; 8.3 \u00b1 0.6 pg\/ml, <jats:italic>p<\/jats:italic> = 0.006; 5.3 \u00b1 0.1 pg\/ml, <jats:italic>p<\/jats:italic> &lt; 0.001; and 5.1 \u00b1 0.2 pg\/ml, <jats:italic>p<\/jats:italic> &lt; 0.001; respectively) or control subjects (2.1 \u00b1 0.2 \u03bcmol\/l, <jats:italic>p<\/jats:italic> &lt; 0.001; 446 \u00b1 20 U\/ml, <jats:italic>p<\/jats:italic> &lt; 0.001; 6.4 \u00b1 0.2 pg\/ml, <jats:italic>p<\/jats:italic> &lt; 0.001; 5.4 \u00b1 0.1 pg\/ml, <jats:italic>p<\/jats:italic> &lt; 0.001; and 4.7 \u00b1 0.1 pg\/ml, <jats:italic>p<\/jats:italic> &lt; 0.001, respectively). On the contrary, only the mean IL\u20106 level was significantly different between inactive BD and control subjects \n(<jats:italic>p<\/jats:italic> = 0.02). All acute phase reactants were significantly higher in active BD than in inactive period \n(for each, <jats:italic>p<\/jats:italic> &lt; 0.01).<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: High levels of sIL\u20102R, IL\u20106, IL\u20108 and TNF\u2010\u03b1 indicate the activation of immune system in BD. Serum sIL\u20102R, IL\u20106, IL\u20108 and TNF\u2010\u03b1 seem to be related to disease activity. Increased lipid peroxidation suggests oxidative stress in BD and therefore tissue damage in such patients. Amelioration of clinical manifestations would be envisaged by targeting these cytokines, chemokines and lipid peroxidation with pharmacological agents.<\/jats:p>","DOI":"10.1080\/09629350220131935","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:35:35Z","timestamp":1027701335000},"page":"87-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":191,"title":["Serum levels of TNF\u2010\u03b1, sIL\u20102R, IL\u20106, and IL\u20108 are increased and associated with elevated lipid peroxidation in patients with Beh\u00e7et\u2032s disease"],"prefix":"10.1155","volume":"11","author":[{"given":"Cem","family":"Evereklioglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdi","family":"Er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"T\u00fcrk\u00f6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"\u00c7ekmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1]]},"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2002\/615451.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/09629350220131935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T18:19:14Z","timestamp":1723141154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/09629350220131935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1080\/09629350220131935"],"URL":"https:\/\/doi.org\/10.1080\/09629350220131935","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"2002-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}