{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:21:42Z","timestamp":1782375702615,"version":"3.54.5"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"crossref","award":["10416"],"award-info":[{"award-number":["10416"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Institute of Odontology","award":["10416"],"award-info":[{"award-number":["10416"]}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["10416"],"award-info":[{"award-number":["10416"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish National Association against Rheumatism","award":["10416"],"award-info":[{"award-number":["10416"]}]},{"name":"Signe and Reihold Sund's Foundation","award":["10416"],"award-info":[{"award-number":["10416"]}]},{"DOI":"10.13039\/501100005300","name":"Swedish Dental Association","doi-asserted-by":"crossref","award":["10416"],"award-info":[{"award-number":["10416"]}],"id":[{"id":"10.13039\/501100005300","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>: To investigate whether blood serotonin (5\u2010hydroxytryptamine) (5\u2010HT) modulates musculoskeletal pain differently in seropositive and seronegative rheumatoid arthritis (RA).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Patients with temporomandibular joint (TMJ) involvement of seropositive RA (33 patients) or seronegative RA (28 patients) and 26 healthy individuals were included. TMJ pain, general musculoskeletal pain, plasma and serum 5\u2010HT, acute phase reactants and thrombocyte count were investigated.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: The patients with seropositive RA had higher serum (median = 1130 nmol\/l) and plasma (55 nmol\/l) levels of 5\u2010HT than the healthy individuals (704 nmol\/l, <jats:italic>p<\/jats:italic> = 0.044 and 23 nmol\/l, <jats:italic>p<\/jats:italic> &lt; 0.001, respectively), and higher plasma levels of 5\u2010HT than the seronegative patients (14 nmol\/l, <jats:italic>p<\/jats:italic> &lt; 0.001). There was no significant correlation between serum and plasma levels of 5\u2010HT in any group.<\/jats:p><jats:p>In the seropositive RA patients, positive correlations were found between serum levels of 5\u2010HT and the number of painful mandibular movements \n(<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = 0.36, <jats:italic>n<\/jats:italic> = 33, <jats:italic>p<\/jats:italic> = 0.042), as well as pain on maximum mouth opening (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = 0.41, <jats:italic>n<\/jats:italic> = 24, <jats:italic>p<\/jats:italic> = 0.047) and tenderness to digital palpation (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = 0.49, <jats:italic>n<\/jats:italic> = 33, p = 0.003).<\/jats:p><jats:p>In the healthy individuals, there was a negative correlation between plasma level of 5\u2010HT and the TMJ pressure pain threshold \n(<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = \u22120.47\n, <jats:italic>n<\/jats:italic> = 20\n, <jats:italic>p<\/jats:italic> = 0.037).<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Peripheral serotonergic pain mechanisms seem to be activated by blood 5\u2010HT in patients with seropositive RA, in contrast to seronegative patients.<\/jats:p>","DOI":"10.1080\/09629350290000069","type":"journal-article","created":{"date-parts":[[2002,11,23]],"date-time":"2002-11-23T09:55:17Z","timestamp":1038045317000},"page":"211-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Blood serotonin and joint pain in seropositive versus seronegative rheumatoid arthritis"],"prefix":"10.1155","volume":"11","author":[{"given":"Sigvard","family":"Kopp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Alstergren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1]]},"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2002\/286459.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/09629350290000069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T17:26:24Z","timestamp":1723137984000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/09629350290000069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1080\/09629350290000069"],"URL":"https:\/\/doi.org\/10.1080\/09629350290000069","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"2002-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}