{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:58:04Z","timestamp":1777517884655,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100006047","name":"State Committee for Scientific Research","doi-asserted-by":"crossref","award":["4P05B04919"],"award-info":[{"award-number":["4P05B04919"]}],"id":[{"id":"10.13039\/501100006047","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p>The aim of our study was to analyse a significance of tumour necrosis factor (TNF)\u2010\u03b1 promoter gene polymorphisms in relation to the HLA\u2010DR locus in genetic predisposition to pemphigus. TNF\u2010\u03b1 gene polymorphisms in position \u2010238 and \u2010308 were identified using a modified polymerase chain reaction\u2010restriction fragment length polymorphism method in 53 patients with pemphigus (38 with pemphigus vulgaris, 15 with pemphigus foliaceus) and 87 healthy controls. The HLA\u2010DRB1 locus was typed using the polymerase chain reaction SSO method in all the patients and 152 population controls.<\/jats:p><jats:p>Carriers of the TNF\u2010\u03b1 polymorphic \u2010308 A allele were found to be more frequent in the pemphigus foliaceus group in comparison with the control group (odds ratio (OR)=8.12; <jats:italic>P<\/jats:italic> = 0.0005). A significant association between HLA\u2010DRB1*04 (OR=3.86; <jats:italic>P<\/jats:italic>cor = 0.0001) and DRB1*14 (OR=8.4; <jats:italic>P<\/jats:italic>cor = 0.0001) and pemphigus vulgaris was found. In this group of patients a decreased frequency of HLA\u2010DRB1*07 (OR=0.08; <jats:italic>P<\/jats:italic>cor = 0.006) was also identified.<\/jats:p><jats:p>We have shown for the first time a positive association of TNF\u2010\u03b1 polymorphism in position \u2010308 with pemphigus foliaceus.<\/jats:p>","DOI":"10.1080\/09629350310001619735","type":"journal-article","created":{"date-parts":[[2004,4,30]],"date-time":"2004-04-30T02:20:18Z","timestamp":1083291618000},"page":"303-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Tumour necrosis factor\u2010\u03b1 polymorphism as one of the complex inherited factors in pemphigus"],"prefix":"10.1155","volume":"12","author":[{"given":"Jolanta Dorota","family":"Torzecka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Narbutt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sysa-jedrzejowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Borowiec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anetta","family":"Ptasinska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Woszczek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek L.","family":"Kowalski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,1]]},"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2003\/407217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/09629350310001619735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T05:01:32Z","timestamp":1723093292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/09629350310001619735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1080\/09629350310001619735"],"URL":"https:\/\/doi.org\/10.1080\/09629350310001619735","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]},"assertion":[{"value":"2003-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}