{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T04:19:09Z","timestamp":1772597949761,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Faculty of Medicine, University of Bonn","award":["O-107.0063"],"award-info":[{"award-number":["O-107.0063"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p><jats:italic>BACKGROUND<\/jats:italic>: The mechanisms leading to hepatic injury in chronic hepatitis C virus (HCV) infection are only incompletely understood. Recent data propose a correlation of the intrahepatic expression of the CC chemokine RANTES and the degree of periportal and portal inflammatory liver damage.<\/jats:p><jats:p><jats:italic>Aim<\/jats:italic>: Here, we have studied the intrahepatic mRNA levels of CC chemokines RANTES together with that of other members of this chemokine family (MIP\u20101\u03b2, MCP\u20101, and MCP\u20102) in chronic hepatitis C as compared with healthy controls.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Liver samples from 22 HCV\u2010infected patients, nine individuals with primary biliary cirrhosis and from 12 normal controls were included into this study. Intrahepatic mRNA levels of CC chemokines RANTES, MIP\u20101\u03b2, MCP\u20101, and MCP\u20102 were analyzed by a semi\u2010quantitative reverse transcription\/real\u2010time polymerase chain reaction assay.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: In chronic HCV infection, intrahepatic RANTES mRNA levels were significantly higher than in non\u2010infected controls (7.2\u2010fold, <jats:italic>p<\/jats:italic> &lt; 0.001) or in the disease control group (2.8\u2010fold, <jats:italic>p<\/jats:italic> &lt; 0.001) and higher levels of RANTES mRNA levels were observed in livers with an advanced stage of liver cell injury (histologic activity index \u22656), although this difference was not statistically significant (<jats:italic>p<\/jats:italic> = 0.08). In contrast, mRNA levels of MIP\u20101\u03b2 (<jats:italic>p<\/jats:italic> = 0.021) and MCP\u20101 (<jats:italic>p<\/jats:italic> = 0.021) were significantly lower in HCV liver samples while MCP\u20102 expression was similar in all groups analyzed.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: The data support the concept of chemokines as mediators of liver cell injury in chronic hepatitis C.<\/jats:p>","DOI":"10.1080\/09629350400003159","type":"journal-article","created":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T16:51:12Z","timestamp":1105116672000},"page":"357-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Semiquantitative analysis of intrahepatic CC\u2010chemokine mRNAs in chronic hepatitis C"],"prefix":"10.1155","volume":"13","author":[{"given":"Hans Dieter","family":"Nischalke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Nattermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Peter","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilman","family":"Sauerbruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Spengler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz Ludwig","family":"Dumoulin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,1]]},"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2004\/651230.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/09629350400003159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T03:34:50Z","timestamp":1723088090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/09629350400003159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":0,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1080\/09629350400003159"],"URL":"https:\/\/doi.org\/10.1080\/09629350400003159","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"2004-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}