{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:32:46Z","timestamp":1762954366304},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"University Hospital laboratory"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p><jats:italic>BACKGROUND<\/jats:italic>: Studies on peripheral benzodiazepine receptor function have yielded a diverse list of activities of which the anti\u2010inflammatory effects need to be further examined.<\/jats:p><jats:p><jats:italic>Aims<\/jats:italic>: To evaluate the role of steroids, nitric oxide and adenosine\u2010deaminase in the anti\u2010inflammatory effect of PK11195.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Pleurisy was induced by intrapleural injection of carrageenan in mice pre\u2010treated or not with PK11195. Leukocytes, exudation, adenosine\u2010deaminase (ADA) activity and nitric oxide (NO) level were measured. Steroid involvement was evaluated by pre\u2010treatment with D,L\u2010aminogluthetimide before PK11195.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Leukocytes, exudation and NO levels were reduced by PK11195 in the early (4 h) phase. In the late (48 h) phase, PK11195 decreased leukocytes and ADA activity. D,L\u2010aminogluthetimide reversed the effect of PK11195 on exudate (4 h), as well as total and differential leukocytes and NO levels (48 h).<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: Steroids, NO and ADA are implicated in the anti\u2010inflammatory action of PK11195.<\/jats:p>","DOI":"10.1080\/09629350410001688486","type":"journal-article","created":{"date-parts":[[2004,5,10]],"date-time":"2004-05-10T20:03:43Z","timestamp":1084219423000},"page":"93-103","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Involvement of steroids in anti\u2010inflammatory effects of PK11195 in a murine model of pleurisy"],"prefix":"10.1155","volume":"13","author":[{"given":"Marcelo Barreto Spillere","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roseli Coimbra","family":"Farges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00e2nia Silvia","family":"Fr\u00f6de","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,1]]},"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2004\/847896.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/09629350410001688486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T02:52:07Z","timestamp":1723085527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/09629350410001688486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1080\/09629350410001688486"],"URL":"https:\/\/doi.org\/10.1080\/09629350410001688486","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"type":"print","value":"0962-9351"},{"type":"electronic","value":"1466-1861"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"2004-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}