{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:31:33Z","timestamp":1790220693771,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["0062058"],"award-info":[{"award-number":["0062058"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p><jats:italic>OBJECTIVE<\/jats:italic>: Oral lichen planus (OLP) is chronic inflammatory disease of the oral mucosa, presenting in various clinical forms. The etiology of OLP is still unknown but mounting evidence points to the immunologic basis of this disorder.<\/jats:p><jats:p><jats:italic>Aim<\/jats:italic>: Our study was undertaken to quantify the salivary levels of pro\u2010inflammatory tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) in the reticular and the erosive\/atrophic forms of OLP, compared with age\u2010matched healthy control volunteers.<\/jats:p><jats:p><jats:italic>Subjects and methods<\/jats:italic>: Whole saliva from 40 patients with active lesions of OLP, as well as from 20 healthy persons, was investigated for the presence of TNF\u2010\u03b1 by enzyme immunoassay.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Salivary TNF\u2010\u03b1 levels were significantlly increased in patients with OLP in comparison with healthy subjects. The presence of TNF\u2010\u03b1 showed positive correlation to clinical forms of OLP, being significantly higher in the erosive\/atrophic type than in the reticular type of disease.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Saliva provides an ideal medium for the detection of pro\u2010inflammatory markers of the oral cavity. In patients with OLP, TNF\u2010\u03b1 levels in saliva are elevated, correlating with the severity of illness. Salivary TNF\u2010\u03b1 analysis may be a useful diagnostic tool and a potential prognostic marker in OLP.<\/jats:p>","DOI":"10.1080\/09629350410001688530","type":"journal-article","created":{"date-parts":[[2004,5,10]],"date-time":"2004-05-10T20:03:43Z","timestamp":1084219423000},"page":"131-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Salivary levels of tumor necrosis factor\u2010\u03b1 in oral lichen planus"],"prefix":"10.1155","volume":"13","author":[{"given":"Sonja","family":"Pezelj-Ribaric","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana Brekalo","family":"Prso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Abram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Glazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Brumini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marica","family":"Simunovic-Soskic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,1]]},"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2004\/879719.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/09629350410001688530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T02:52:05Z","timestamp":1723085525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/09629350410001688530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1080\/09629350410001688530"],"URL":"https:\/\/doi.org\/10.1080\/09629350410001688530","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"2004-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}