{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T13:40:01Z","timestamp":1723124401746},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1095,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>Interleukin\u20106 (IL\u20106) and soluble interleukin\u20106 receptor (sIL\u20106R) were detected in supernatants of cultures of B chronic lymphatic leukaemia (CLL) lymphocytes. Phorbol\u201012\u2010myristate 13 acetate (PMA) caused a decrease in the levels of IL\u20106 in 14 out of 16 cultures and an increase in levels of sIL6R in all 15 cases. The effect of pokeweed mitogen (PWM) was variable and not significant. The levels of IL\u20106 were below the detection limit (60 pg\/ml) in sera of 13 CLL patients whereas sIL\u20106R was detected (13 ng\/ml to 97 ng\/ml) in the 13 sera. IL6 was not detected in cultures of unstimulated or stimulated with PMA or PWM normal human B cells. Levels of sIL\u20106R were minimal in cultures of normal B lymphocytes and were increased in PMA stimulated cultures. The results are consistent with the view that B\u2010CLL cells produce spontaneously IL\u20106 which could act in an autocrine fashion to cause shedding of surface IL\u20106R and account for the correlation found between serum levels of sIL\u20106R and B\u2010CLL lymphocyte numbers. The fall in levels of IL\u20106 in PMA stimulated CLL cultures might express masking or degradation of IL\u20106 after combination with the receptor.<\/jats:p>","DOI":"10.1080\/09629359791857","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:10:43Z","timestamp":1027699843000},"page":"147-153","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interleukin\u20106 and interleukin\u20106 receptor secretion by chronic lymphatic leukaemia and normal B lymphocytes: effect of PMA and PWM"],"prefix":"10.1155","volume":"6","author":[{"given":"I.","family":"Drucker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Klajman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Revel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Manor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ben-Efraim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Novick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,1]]},"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/1997\/348437.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/09629359791857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T12:45:35Z","timestamp":1723121135000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/09629359791857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1080\/09629359791857"],"URL":"https:\/\/doi.org\/10.1080\/09629359791857","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"type":"print","value":"0962-9351"},{"type":"electronic","value":"1466-1861"}],"subject":[],"published":{"date-parts":[[1997,1]]},"assertion":[{"value":"1997-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}