{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:47:13Z","timestamp":1788871633571,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>\n                    This study intended to characterize pharmacologically the mediator(s ) released in the inflammation induced by Soluble Egg Antigen (SEA), the main antigen released from eggs of\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    , in rat hindpaws . A single intraplantar injection of 0.1\u2013100 \u03bcg SEA at day zero induced a dose\u2010dependent increase in the volume of rat hindpaws characterizing an oedema of quick onset (within 15 min) and\n4 h\u2010duration, which was confirmed by his topathological analys is of the paws . A second injection of SEA\nin the same paw (1\u201310 \u03bcg) 28 days later induced an increased dose \u2010dependent oedematogenic response.\nThe early oedematogenic response following SEA sensitization was derived from serotonin release and\ninterleukin\u20101 (IL\u20101), since treatment with either pizotifen or anantibody against IL\u20101, reduced the\nresponse by 60% and 48%, respectively. The increased oedematogenic response derived from SEA\u2010challenge (10 \u03bcg) of rat paws derived from a local rather than systemic reaction, since it was not\nobserved if the sensitization was in the contralateral paw or the peritoneal cavity of the animals. Chronic\ntre atment with inhibitors of IL\u20102 synthesis \/ release such as cyclosporin or dexamethasone during the\nsens itization phase reduced the oedematogenic response due to SEA challenge by 51% and 55%,\nrespectively. These data suggested that SEA\u2010challenge was immune\u2010derived and dependent of IL\u20102 release. It\nis discussed the association between cytokine release and the resistance of rats to\n                    <jats:italic>S. mans o ni<\/jats:italic>\n                    infe ction.\n                  <\/jats:p>","DOI":"10.1080\/09629359890947","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T12:10:43Z","timestamp":1027685443000},"page":"261-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacological evidence supporting a role for IL\u20101, IL\u20102 and serotonin in the inflammation induced by\n                    <i>Schistosoma mansoni<\/i>\n                    Soluble Egg Antigen (SEA) in rat paws"],"prefix":"10.1155","volume":"7","author":[{"given":"C. M. F.","family":"Pacheco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A. P.","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M. Z.","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. A.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M. M.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. R. M.","family":"Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. N.","family":"Francischi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1998,1]]},"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/1998\/590764.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/09629359890947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T07:42:40Z","timestamp":1723102960000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/09629359890947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1080\/09629359890947"],"URL":"https:\/\/doi.org\/10.1080\/09629359890947","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1]]},"assertion":[{"value":"1998-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}