{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:59:49Z","timestamp":1777946389237,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p>Beh\u00e7et\u2032s disease (BD) is a current systemic vasculitis of unknown aetiology. Eyes, skin, joints, the oral cavity, genital system, blood vessels, central nervous system and lung are usually involved. Defective regulation of programmed cell death (apoptosis) may play a role in the development of (BD), and the protooncogene Bcl\u20102 is involved in the control of apoptosis in immunocompetent cells. We therefore wished to investigate the expression of Bcl\u20102 in the peripheral lymphocytes and in two inflammatory sites of patients with active BD: bronchoalveolar lavage (BAL) and cerebrospinal fluid (CSF) lymphocytes. Levels of Bcl\u20102 expression in the lymphocytes of patients with BD and, for comparison, in the lymphocytes of healthy controls and non\u2010inflammatory neurological diseases (NIND), were studied by two\u2010colour cytofluorography and RNA analysis. In BD patients, a significant proportion of T cells expressed increased amounts of Bcl\u20102 protein, both in peripheral blood and in inflammatory sites. Mononuclear cells of patients with BD showed increased amount of Bcl\u20102 messenger RNA. The in vitro incubation of T lymphocytes with IL\u201010, significantly increased the Bcl\u20102 expression, specifically in T lymphocytes from inflammatory sites. In active BD, stimulation of HSV\u20101 T lymphocytes slightly increased Bcl\u20102 expression, not significantly different from unstimulated HSV\u20101 T cells. The occurrence of circulating T lymphocytes with abnormally high Bcl\u20102 expression in peripheral circulation and in inflammatory sites may be explained in part by the increased <jats:italic>in vivo<\/jats:italic> activation levels, and by aetiopathological agent(s): our findings seem to indicate an important role in the chronic inflammation in BD.<\/jats:p>","DOI":"10.1080\/09629359990595","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:10:43Z","timestamp":1027699843000},"page":"101-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Expression of Bcl\u20102 in Inflammatory Sites from Patients with Active Beh\u00e7et\u2032s Disease"],"prefix":"10.1155","volume":"8","author":[{"given":"K.","family":"Hamzaoui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hamzaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Zakraoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Chabbou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,1]]},"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/1999\/757864.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/09629359990595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T01:47:11Z","timestamp":1723081631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/09629359990595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["10.1080\/09629359990595"],"URL":"https:\/\/doi.org\/10.1080\/09629359990595","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1]]},"assertion":[{"value":"1999-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}