{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T19:15:32Z","timestamp":1782501332484,"version":"3.54.5"},"reference-count":102,"publisher":"Informa UK Limited","issue":"1","funder":[{"name":"Amgen S.A"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Hematology"],"published-print":{"date-parts":[[2017,1,2]]},"DOI":"10.1080\/10245332.2016.1219497","type":"journal-article","created":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T07:44:51Z","timestamp":1474962291000},"page":"41-53","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":59,"title":["Advances in the pathophysiology of primary immune thrombocytopenia"],"prefix":"10.1080","volume":"22","author":[{"given":"Mar\u00eda","family":"Perera","sequence":"first","affiliation":[{"name":"Haematology Service, University Hospital Doctor Negr\u00edn, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Garrido","sequence":"additional","affiliation":[{"name":"Medical Department, Amgen S.A., Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,9,27]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.02.001"},{"issue":"3","key":"CIT0003","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1182\/blood.V94.3.909.415k02_909_913","volume":"94","author":"Frederiksen H","year":"1999","journal-title":"Blood."},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04547.x"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02147.x"},{"issue":"2","key":"CIT0007","first-page":"226","volume":"86","author":"Hedman A","year":"1997","journal-title":"Acta Paediatr Oslo Nor 1992."},{"key":"CIT0008","first-page":"374","volume":"78","author":"Shulman NR","year":"1965","journal-title":"Trans Assoc Am Physicians."},{"issue":"1","key":"CIT0009","first-page":"1","volume":"38","author":"Harrington WJ","year":"1951","journal-title":"J Lab Clin Med."},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1965.tb18984.x"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90450-2"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.23.11104"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1038\/369533a0"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1038\/369565a0"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205323"},{"key":"CIT0016","first-page":"6","volume":"17","author":"Wolber E-M","year":"2002","journal-title":"News Physiol Sci."},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01571.x"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03184.x"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113060"},{"issue":"10","key":"CIT0020","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1182\/blood.V87.10.4068.bloodjournal87104068","volume":"87","author":"Emmons RV","year":"1996","journal-title":"Blood"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26674"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0275"},{"issue":"10","key":"CIT0023","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1182\/blood.V78.10.2619.2619","volume":"78","author":"Semple JW","year":"1991","journal-title":"Blood"},{"issue":"10","key":"CIT0024","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1182\/blood.V87.10.4245.bloodjournal87104245","volume":"87","author":"Semple JW","year":"1996","journal-title":"Blood"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2003.00138.x"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4238"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1038\/nm921"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00622.x"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1305780"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225565"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2011.11.011"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-466375"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3908"},{"key":"CIT0034","volume-title":"Roitt's essential immunology","author":"Roitt I","year":"2001","edition":"10"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1038\/ni833"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.4.475"},{"key":"CIT0037","first-page":"43","volume":"293","author":"Coutinho A","year":"2005","journal-title":"Curr Top Microbiol Immunol."},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1038\/nri3155"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.10.005"},{"issue":"2","key":"CIT0040","first-page":"204","volume":"12","author":"Zhang H-Y","year":"2004","journal-title":"[Zhongguo Shi Yan Xue Ye Xue Za Zhi Zhongguo Bing Li Sheng Li Xue Hui] J Exp Hematol Chin Assoc Pathophysiol."},{"issue":"4","key":"CIT0041","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1182\/blood.V100.4.1388.h81602001388_1388_1398","volume":"100","author":"Roark JH","year":"2002","journal-title":"Blood"},{"issue":"3","key":"CIT0042","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1182\/blood.V37.3.316.316","volume":"37","author":"McMillan R","year":"1971","journal-title":"Blood"},{"issue":"2","key":"CIT0043","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1182\/blood.V67.2.421.421","volume":"67","author":"Stahl CP","year":"1986","journal-title":"Blood"},{"issue":"1","key":"CIT0044","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1182\/blood.V80.1.162.162","volume":"80","author":"Bettaieb A","year":"1992","journal-title":"Blood"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1872.x"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.11.001"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1985.tb00945.x"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04843.x"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-501858"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/352059"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2202"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1038\/35100529"},{"issue":"4","key":"CIT0053","first-page":"239","volume":"1","author":"Xu D","year":"2004","journal-title":"Cell Mol Immunol."},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(02)00013-4"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.005015"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071059"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-062695"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01534.x"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2011.02600.x"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1292-2"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-344051"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-432575"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.009"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2013.03.011"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.01.018"},{"issue":"10","key":"CIT0066","first-page":"5569","volume":"186","author":"Carter NA","year":"2011","journal-title":"J Immunol Baltim Md 1950."},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.4110\/in.2010.10.6.247"},{"issue":"3","key":"CIT0068","first-page":"471","volume":"7","author":"Guo Y","year":"2015","journal-title":"J Thorac Dis."},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13567"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-434605"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1048.2002.03345.x"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.04.025"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.046417"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2011.01745.x"},{"issue":"3","key":"CIT0075","first-page":"213","volume":"49","author":"Chang D","year":"2010","journal-title":"Zhonghua Nei Ke Za Zhi."},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2011.05.003"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2013.03.018"},{"issue":"3","key":"CIT0078","first-page":"730","volume":"19","author":"Cao J","year":"2011","journal-title":"[Zhongguo Shi Yan Xue Ye Xue Za Zhi Zhongguo Bing Li Sheng Li Xue Hui] J Exp Hematol Chin Assoc Pathophysiol."},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050909"},{"issue":"5","key":"CIT0080","first-page":"1264","volume":"19","author":"Jia R-P","year":"2011","journal-title":"[Zhongguo Shi Yan Xue Ye Xue Za Zhi Zhongguo Bing Li Sheng Li Xue Hui] J Exp Hematol Chin Assoc Pathophysiol."},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-413526"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-424648"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65689"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2014.898746"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21872"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24342"},{"issue":"3","key":"CIT0087","first-page":"221","volume":"12","author":"Warrier R","year":"2012","journal-title":"Ochsner J."},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3282ab98c7"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1855-5"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60203-2"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2013.08.006"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/548085"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0753-z"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-129262"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00917.x"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23994"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12888"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2011.e20"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12139"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1179\/1607845415Y.0000000041"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23900"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-281717"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000033597.45947.0F"}],"container-title":["Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10245332.2016.1219497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T08:09:06Z","timestamp":1601107746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10245332.2016.1219497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,27]]},"references-count":102,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,10,14]]},"published-print":{"date-parts":[[2017,1,2]]}},"alternative-id":["10.1080\/10245332.2016.1219497"],"URL":"https:\/\/doi.org\/10.1080\/10245332.2016.1219497","relation":{},"ISSN":["1607-8454"],"issn-type":[{"value":"1607-8454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,27]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=yhem20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=yhem20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}