{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:40:02Z","timestamp":1785908402069,"version":"3.56.0"},"reference-count":64,"publisher":"Informa UK Limited","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Critical Reviews in Analytical Chemistry"],"published-print":{"date-parts":[[2022,7,4]]},"DOI":"10.1080\/10408347.2020.1839737","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T06:30:52Z","timestamp":1604385052000},"page":"897-905","source":"Crossref","is-referenced-by-count":8,"title":["Bioproperties, Nanostructured System and Analytical and Bioanalytical Methods for Determination of Rapamycin: A Review"],"prefix":"10.1080","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2208-1465","authenticated-orcid":false,"given":"Karen Cristina","family":"dos Santos","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leidiana Rocha","family":"dos Reis","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Fernanda","family":"Rodero","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Miguel","family":"S\u00e1bio","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6083-8177","authenticated-orcid":false,"given":"Alberto Gomes Tavares","family":"Junior","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Palmira Daflon","family":"Gremi\u00e3o","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6698-0545","authenticated-orcid":false,"given":"Marlus","family":"Chorilli","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.28.721"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315185"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11080384"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b01431"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118529"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.105098"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-019-2667-7"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2014.02.015"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2019.109518"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1021\/jm068049o"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1996.d01-52.x"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002769"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1997.tb04318.x"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.cqn.2015.11.005"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199311000-00029"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1854323"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12089"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.12.004"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.03.014"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665112000754"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2018.10.051"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1038\/nature11861"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106703200"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.05.026"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.02.035"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.01.001"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi113"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3531"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1039\/C9TB00912D"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.04.067"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.3390\/md17100581"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.12.031"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S216432"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.01.068"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b00617"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0987"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.22037\/ijpr.2018.2274"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27243"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.05.026"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.7b00469"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119605"},{"key":"CIT0042","first-page":"444","volume":"4","author":"Bhagyasree T.","year":"2014","journal-title":"Int. J. Pharm. Res. Anal."},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40422003000100020"},{"key":"CIT0044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4155\/ppa.13.76","volume":"3","author":"Shah Kruti V.","year":"2014","journal-title":"J. Pharm. Anal"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2017.10.016"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181c49a00"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.02.029"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2010.06.030"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1295"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2010.531141"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.192"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/571201"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2019.121772"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2020.01.077"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2019.11.006"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bms205"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.5681\/apb.2012.021"},{"key":"CIT0058","first-page":"77","volume":"12","author":"Sobhani H.","year":"2013","journal-title":"Iran. J. Pharm. Res"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2015.03.200"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-020-4190-2"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.07.065"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2007.00701.x"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.22037\/ijpr.2013.1274"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2013.03.014"}],"container-title":["Critical Reviews in Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10408347.2020.1839737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T16:07:51Z","timestamp":1674922071000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10408347.2020.1839737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,2]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,7,4]]}},"alternative-id":["10.1080\/10408347.2020.1839737"],"URL":"https:\/\/doi.org\/10.1080\/10408347.2020.1839737","relation":{},"ISSN":["1040-8347","1547-6510"],"issn-type":[{"value":"1040-8347","type":"print"},{"value":"1547-6510","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,2]]}}}