{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:35:48Z","timestamp":1789958148810,"version":"4.0.1"},"reference-count":78,"publisher":"Informa UK Limited","issue":"2","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"This work was supported by Altria Client Services (ALCS), LLC."}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Toxicology"],"published-print":{"date-parts":[[2017,2,7]]},"DOI":"10.1080\/10408444.2016.1236071","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T11:50:06Z","timestamp":1478865006000},"page":"98-120","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":34,"title":["A critical review of the literature to conduct a toxicity assessment for oral exposure to methyl salicylate"],"prefix":"10.1080","volume":"47","author":[{"given":"Tracy","family":"Greene","sequence":"first","affiliation":[{"name":"Environment and Health Division, Ramboll Environ, Monroe, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Rogers","sequence":"additional","affiliation":[{"name":"Environment and Health Division, Ramboll Environ, Monroe, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Franzen","sequence":"additional","affiliation":[{"name":"Environment and Health Division, Ramboll Environ, Monroe, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robinan","family":"Gentry","sequence":"additional","affiliation":[{"name":"Environment and Health Division, Ramboll Environ, Monroe, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,11,11]]},"reference":[{"key":"CIT0002","unstructured":"Abbot DD, Harrisson JWE. 1978. Methyl salicylate: studies of osseous changes in the rat, reproduction in the rat and mouse, and liver and kidney effects in the dog. Unpublished communication to the Flavor and Extract Manufacturers Association (As cited in CIR 2003, NFSA 2012)."},{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1994.1134"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1080\/10715760400023853"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1080\/20018091094303"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342120-00004"},{"key":"CIT0006","unstructured":"ChemSpider. 2015. Search and share chemistry [Internet]. Royal Society of Chemistry. [cited 2016 Apr 14]. Available from: http:\/\/www.chemspider.com\/Chemical-Structure.13848808.html?rid =56c5d453-3418-4c23-9d07-6dbb9d658fd2."},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.12.015"},{"key":"CIT0008","unstructured":"Code of Federal Regulations. 2015. From the U.S. Government Printing Office via GPA access. Title 21, vol. 3, part 175. [cited 2016 Aug 31]; Available from: http:\/\/www.ecfr.gov\/cgi-bin\/text-idx?SID=a52bd4f6a793316bc823387b87c80829&mc=true&node=pt21.3.175&rgn=div5#se21.3.175_1105."},{"issue":"3","key":"CIT0009","first-page":"1","volume":"22","author":"[CIR] Cosmetic Ingredient Review","year":"2003","journal-title":"Int J Toxicol"},{"issue":"1","key":"CIT0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10915810701876265","volume":"27","author":"[CIR] Cosmetic Ingredient Review","year":"2008","journal-title":"Int J Toxicol"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(71)90227-4"},{"key":"CIT0012","first-page":"75","volume":"58","author":"Crossland AM.","year":"1948","journal-title":"Can Med Assoc J"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(88)90104-2"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.2460\/ajvr.1972.33.06.1253","volume":"33","author":"Davis LE","year":"1972","journal-title":"Am J Vet Res"},{"key":"CIT0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0022-3565(25)26029-3","volume":"132","author":"Davison C","year":"1961","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2004.00292.x"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2012.2785"},{"key":"CIT0018","first-page":"385","volume":"9","author":"Gatti G","year":"1989","journal-title":"Int J Clin Pharm Res"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1201\/9780203646960.ch5"},{"key":"CIT0020","unstructured":"Gulati DK, Choudhury H, Chambers R, Sabharwal PS, Lamb JIV. 1984. Methyl salicylate: fertility assessment in cd-1 mice when administered by gavage. National Toxicology Program, National Institutes of Environmental Health Sciences. NTP-85-022. Available from: https:\/\/www.ntis.gov\/products\/ntrl\/."},{"key":"CIT0021","unstructured":"Harrisson JWE, Abbott DD, and Packman EW. 1963. Salicylates and other hydroxybenzoates: effect upon osseous tissue of young rats. Federation Proceedings, vol. 22, p. 554."},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.3109\/00498258609043527"},{"key":"CIT0023","unstructured":"Infurna R, Beyer B, Twitty L, Koehler G, Daughtrey W. 1990. Evaluation of the dermal absorption and teratogenic potential of methyl salicylate in a petroleum-based grease. East Millstone (NJ): Exxon Biomedical Sciences, Inc. Teratology. 41:566."},{"key":"CIT0024","unstructured":"[IPCS] International Program on Chemical Safety. (1987). Environmental Health Criteria 70. Principles for the safety assessment of food additives and contaminants in food. World Health Organization, Geneva. Available from: http:\/\/www.inchem.org\/documents\/ehc\/ehc\/ehc70.htm#SectionNumber:5.5."},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(84)90271-0"},{"key":"CIT0026","unstructured":"[JECFA] Joint FAO\/WHO Expert Committee on Food Additives. 1968. Specifications for the identity and purity of food additives and their toxicological evaluation: some flavoring substances and non-nutritive sweetening agents. Eleventh report of the Joint FAO\/WHO Expert Committee on Food Additives. World Health Organization Technical Report Series No. 383, FAO Nutrition Meetings Report Series No. 44, Geneva."},{"key":"CIT0027","unstructured":"[JECFA] Joint FAO\/WHO Expert Committee on Food Additives. 2002. Evaluation of certain food additives and contaminants. Fifty-seventh report of the Joint FAO\/WHO Expert Committee on Food Additives. WHO Technical Report Series 909. Geneva: World Health Organization."},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.1996.1076"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1080\/02652039309374151"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd1959.34.183"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.09.053"},{"key":"CIT0032","unstructured":"LaWall and Harrisson Research Laboratories, Inc. 1964. Study of Methyl Salicylate on rats. L&H 58188. (Submitted by FDA in response to an FOI request \u2013 1998; 120 pages) (As cited in CIR 2003)."},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600551135"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1080\/01926230252824725"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1039\/C4AY00271G"},{"key":"CIT0036","first-page":"260","volume":"53","author":"Lucker PW","year":"2003","journal-title":"Arzneimittel-Forsch"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1986.98"},{"key":"CIT0038","unstructured":"Morrissey RE, Lamb J, Morris R, Chapin R, Gulati D, Heindel J. 1989. Results and evaluations of 48 continuous breeding reproduction studies conducted in mice. Developmental and Reproductive Toxicology Group, NIEHS, NTP Program, Research Triangle Park, North Carolina, Analytical Sciences Inc., Durham, North Carolina, Environmental Health Research and Testing, Inc., Lexington, Kentucky. Fund Appl Toxicol. 13:747\u2013777."},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1002\/em.2860080802"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(81)90154-5"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198510020-00004"},{"key":"CIT0042","unstructured":"[NFSA] Norwegian Food Safety Authority. 2012. Risk profile methyl salicylate CAS no. 119-36-8."},{"key":"CIT0043","unstructured":"[NRC] National Research Council of the National Academies. 2014. Review of EPA\u2019s Integrated Risk Information (IRIS) Process. Committee to Review the IRIS Process Board on Environmental Studies and Toxicology Division on Earth and Life Studies."},{"key":"CIT0044","unstructured":"[NTP] National Toxicology Program. 1984. Abstract for RACB82104 \u2013 Methyl salicylate CAS no. 119-36-8. NTIS #RACB82104. Available from: http:\/\/ntp.niehs.nih.gov\/testing\/types\/repro\/abstracts\/racb\/index-8.html."},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-6264(78)80132-1"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/0015-6264(79)90330-4"},{"key":"CIT0047","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0015-6264(79)90288-8","volume":"17","author":"Opdyke DL.","year":"1979","journal-title":"Food Cosmet Toxicol"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420280313"},{"key":"CIT0049","first-page":"62","volume":"3","author":"Packman EW","year":"1961","journal-title":"Pharmacologist"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1_suppl.39S"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1201\/9780203646960.ch1"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1201\/9780203646960.ch7"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1201\/9780203646960.ch8"},{"key":"CIT0054","first-page":"687","volume-title":"Goodman & Gilman's the pharmacological basis of therapeutics","author":"Roberts LJIII","year":"2001"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90451-5"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1981.00340030090016"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(75)90064-7"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420270214"},{"key":"CIT0059","unstructured":"[USEPA] United States Environmental Protection Agency. 1985. Reference values for risk assessment. United States Environmental Protection Agency, Washington, (DC): Environmental Criteria and Assessment Office."},{"key":"CIT0060","unstructured":"[USEPA] United States Environmental Protection Agency. 1988. Research and Development: General Quantitative Risk Assessment Guidelines for Noncancer Health Effects. Prepared for Risk Assessment Forum. Sixth Draft. ECAD-CIN-538."},{"key":"CIT0061","unstructured":"[USEPA] United States Environmental Protection Agency. 1993. Reference dose (RfD): Description and use in health risk assessments. Background document 1A, March 15, 1993. Integrated Risk Information System (IRIS), United States Environmental Protection Agency. Available from: http:\/\/www.epa.gov\/iris\/rfd.htm."},{"key":"CIT0062","unstructured":"[USEPA] United States Environmental Protection Agency. 1994. Methods for derivation of inhalation reference concentrations and application of inhalation dosimetry. United States Environmental Protection Agency, Office of Research and Development. EPA\/600\/8 90\/066F."},{"key":"CIT0063","unstructured":"[USEPA] United States Environmental Protection Agency. 2002. A review of the reference dose and reference concentration processes. Final report. Risk Assessment Forum, United States Environmental Protection Agency, Washington, DC. EPA\/630\/P-02\/002F."},{"key":"CIT0064","unstructured":"[USEPA] United States Environmental Protection Agency. 2005a. Reregistration eligibility decision for methyl salicylate. United States Environmental Protection Agency. OPP Chemical Code: 076601. Issued September 27, 2005."},{"key":"CIT0065","unstructured":"[USEPA] United States Environmental Protection Agency. 2005b. Guidelines for carcinogen risk assessment. United States Environmental Protection Agency. EPA\/630\/P-03\/001F."},{"key":"CIT0067","unstructured":"[USEPA] Untied States Environmental Protection Agency. 2011a. Recommended Use of BW3\/4as the Default Method in Derivation of the Oral Reference Dose. EPA\/100\/R11\/001."},{"key":"CIT0068","unstructured":"[USEPA] Untied States Environmental Protection Agency. 2011b. Exposure Factors Handbook: 2011 Edition. EPA\/600\/R-090\/052F. Available at: Available from: https:\/\/cfpub.epa.gov\/ncea\/risk\/recordisplay.cfm?deid =236252."},{"key":"CIT0066","unstructured":"[USEPA] United States Environmental Protection Agency. 2012. Benchmark Dose Technical Guidance. Risk Assessment Forum. United States Environmental Protection Agency. EPA\/100\/R-12\/001."},{"key":"CIT0069","unstructured":"[USEPA] Untied States Environmental Protection Agency. 2016 Benchmark Dose Software (BMDS). Available at: https:\/\/www.epa.gov\/bmds."},{"key":"CIT0070","unstructured":"[USFDA] United States Food and Drug Administration. 1966. Chronic oral toxicity study of Methyl Salicylate using dogs and reproductive and developmental effects oral study of Methyl Salicylate using rats. Studies dated May. Submitted by FDA in response to an FOI request \u2013 1998; 33 pages (As cited in CIR 2003)."},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(03)00379-7"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2008.11.017"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.10.014"},{"key":"CIT0074","first-page":"129","volume":"11","author":"Vigano G","year":"1991","journal-title":"Int J Clin Pharm Res"},{"key":"CIT0075","first-page":"315","volume":"35","author":"Warknay J","year":"1959","journal-title":"Am J Pathol"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(63)90003-6"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-120022002"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.12.004"}],"container-title":["Critical Reviews in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tandfonline.com\/doi\/pdf\/10.1080\/10408444.2016.1236071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10408444.2016.1236071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:15:56Z","timestamp":1749726956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10408444.2016.1236071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,11]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2,7]]}},"alternative-id":["10.1080\/10408444.2016.1236071"],"URL":"https:\/\/doi.org\/10.1080\/10408444.2016.1236071","relation":{},"ISSN":["1040-8444","1547-6898"],"issn-type":[{"value":"1040-8444","type":"print"},{"value":"1547-6898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,11]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itxc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itxc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}