{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:18:29Z","timestamp":1792484309797,"version":"4.5.0"},"reference-count":401,"publisher":"Informa UK Limited","issue":"8","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Toxicology"],"published-print":{"date-parts":[[2018,9,14]]},"DOI":"10.1080\/10408444.2018.1504276","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T06:53:40Z","timestamp":1543215220000},"page":"615-665","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":50,"title":["The development of environmentally acceptable fluorocarbons"],"prefix":"10.1080","volume":"48","author":[{"given":"George M.","family":"Rusch","sequence":"first","affiliation":[{"name":"Veritox Toxicology and Industrial Hygiene, Sarasota, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1975.tb02340.x"},{"key":"CIT0002","first-page":"120","volume-title":"Technical Support Document 1,1,1,2-Tetrafluoroethane","volume":"2","author":"AEGL","year":"2002"},{"key":"CIT0003","first-page":"120","volume-title":"Technical Support Document 1,1-Dichloro-1-Fluoroethane., National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances","volume":"2","author":"AEGL","year":"2002"},{"key":"CIT0004","volume-title":"Atmospheric and Environmental Research, Private communications to AFEAS","author":"AER.","year":"1992"},{"key":"CIT0005","volume-title":"Alternative Fluorocarbons Environment Acceptability Study, Energy and Global Warming Impacts of CFC Alternative Technologies, Executive Summary","author":"AFEAS","year":"1991"},{"key":"CIT0006","volume-title":"Alternative Fluorocarbons Environment Acceptability Study. Proceedings of the AFEAS Workshop: Atmospheric Wet and Dry Deposition of Carbonyl and Haloacetyl Halides","author":"AFEAS","year":"1992"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1177\/096032719501400903"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1177\/096032719601500609"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1177\/096032719501400902"},{"key":"CIT0010","volume-title":"A Four-Hour Acute Inhalation Toxicity Study with HFC 245ea in Mice (personal communication)","author":"AlliedSignal.","year":"1997"},{"key":"CIT0011","volume-title":"Cardiac Sensitization Study with HFC 245ea in the Dog (personal communication)","author":"AlliedSignal","year":"1997"},{"key":"CIT0012","volume-title":"Genotoxic Evaluation of HFC 245ea with the Salmonella typhimurium Reverse Mutation Assay (personal communication)","author":"AlliedSignal","year":"1997"},{"key":"CIT0013","volume-title":"An Evaluation of HFC 245ea: The Chromosome Aberration Test Using Human Lymphocytes (personal communication)","author":"AlliedSignal.","year":"1997"},{"key":"CIT0014","volume-title":"An Evaluation of HCFC 245ea in the In Vivo Mouse Micronucleus Assay (personal communication)","author":"AlliedSignal.","year":"1997"},{"key":"CIT0015","volume-title":"A Two Week Dose Range-Finding Inhalation Toxicity Study with HFC 245fa in Dogs (unpublished data), Huntingdon Life Sci. Rep. ALS 174\/982608","author":"AlliedSignal.","year":"1998"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600680210"},{"key":"CIT0017","volume-title":"Arcton 134a: A Cytogenetic Study in the Rat, CTL Study No. SR0002","author":"Anderson D","year":"1979"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1007\/BF00380702"},{"key":"CIT0019","first-page":"138","volume":"47","author":"Antti-Poika M","year":"1990","journal-title":"Br J Ind Med"},{"key":"CIT0020","volume-title":"Report on Reverse Mutation Assay in Bacteria on Tetrafluoroethane, Japan Bioassay Laboratory","author":"Araki A","year":"1991"},{"key":"CIT0021","volume-title":"Report on a Chromosomal Aberration Test of Difluoromethane in Cultured Mammalian Cells, Japan Bioassay Lab","author":"Asakura M","year":"1993"},{"key":"CIT0022","volume-title":"Report on a Chromosomal Aberration Test of 1,1,1,2-Tetrafluoro-Ethane in Cultured Mammalian Cells, Japan Bioassay Laboratory","author":"Asakura M","year":"1991"},{"key":"CIT0023","unstructured":"ASHRAE. 2017. Chemours Application to ASHRAE; Zeotropic Refrigerant Blend: R-744\/R-125\/R-1234yf\/R-134a. May 2017 personal communication from Dr. Gary Jepson to the author."},{"key":"CIT0024","unstructured":"Atochem. 1986. Chlorodifluoromethane: Local Tolerance Tests in the Rabbit, Ocular Irritation\u2014Cutaneous Irritation\u2014Cutaneous Sensitizing Test in the Guinea Pig. Paris: Hazleton France for Elf Atochem, La Defense, Hazleton IFT, Rep. No. 603344."},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1007\/BF00379077"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1097\/01.paf.0000202715.71009.0e"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7826207"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(74)90040-7"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(75)90009-8"},{"key":"CIT0030","first-page":"3071","volume-title":"Patty\u2019s Industrial Hygiene and Toxicology","volume":"2","author":"Aviado DM","year":"1981","edition":"3"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(75)90088-8"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1080\/0002889728506632"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1080\/0002889738506816"},{"key":"CIT0034","unstructured":"Barsky FC. 1976. In Vitro Microbial Mutagenicity Studies of Ethane, 1-Chloro-1,2,2,2-Trifluoro. Newark (DE): Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 349-76."},{"key":"CIT0035","unstructured":"Barsky FC, Butterworth BE. 1976. In Vitro Microbial Mutagenicity Studies of Ethane Chlorodifluoro, Newark (DE): Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 322-76."},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(80)90002-0"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1970.03170250031004"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1021\/tx025505c"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(74)90031-6"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(74)90262-2"},{"key":"CIT0041","volume-title":"CFC141b: Investigation of Mutagenic Activity at the HGPRT Locus in a Chinese Hamster V79 Cell Mutation System","author":"Bootman J","year":"1998"},{"key":"CIT0042","volume-title":"In Vitro Assessment of the Clastogenic Activity of CFC 141b in Cultured Hamster Ovary (CHO-K1) Cells (88\/PSV007\/214)","author":"Bootman J","year":"1988"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1080\/15428110308984791"},{"key":"CIT0044","unstructured":"Brock WJ. 1988a. Acute Dermal Toxicity Study of FC-141b. Newark, DE.: Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 501-88."},{"key":"CIT0045","unstructured":"Brock WJ. 1988b. DuPont Haskell Laboratory for Toxicology & Industrial Medicine. Primary Dermal Irritation Study with NCFC 123 in Rabbits. Newark (DE): Haskell Laboratory, E.I. du Pont de Nemours & Co. HLR 535-88 (unpublished data)."},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1080\/109158100224881"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(95)00008-P"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/S0273-2300(03)00072-2"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1996.0092"},{"key":"CIT0050","unstructured":"Brodzinsky R, Singh HB. 1982. Volatile Organic Chemicals in the Atmosphere: An Assessment of Available Data. Research Triangle Park, NC.: Environmental Sciences Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency. Final report on Contract No. 68-022-3452."},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1520\/JFS14284J"},{"key":"CIT0052","first-page":"165","volume":"125","author":"Brugnone F","year":"1981","journal-title":"Collect M\u00e9d Leg Toxicol M\u00e9d"},{"key":"CIT0053","unstructured":"Brusick DJ. 1976. Mutagenicity Data of Genetron 134a. Morristown (NJ): Litton Bionetics for Allied Chemical Corp. Final Report, LBI Proj. No. 2683 (unpublished data)."},{"key":"CIT0054","unstructured":"Brusick DJ. 1976. Mutagenicity Evaluation of Genetron 124 (LBI No. 2547). Morristown (NJ): Litton Bionetics for Allied Chemical Corp."},{"key":"CIT0055","volume-title":"Crossover Study with HCFC 123 in Lactating Sprague\u2013Dawley Rats including Additional Studies on Milk Production and Metabolites in Offspring Urine","author":"Buschmann J","year":"1996"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2012.12.006"},{"key":"CIT0057","unstructured":"Butterworth BE. 1976. In Vitro Microbial Mutagenicity Studies of Methane, Chlorodifluorocarbon. Newark (DE): Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 398-76."},{"key":"CIT0058","volume-title":"HCFC 123\u2014An Evaluation Using the Salmonella Mutagenicity Assay","author":"Callander RD","year":"1989"},{"key":"CIT0059","unstructured":"Callander RD, Priestley KP. 1990. HFC 134a. An Evaluation Using the Salmonella Mutagenicity Assay, CTL. Alderley Park, Cheshire, UK: Imperial Chemical Industries, Central Toxicology Laboratory. Rep. No. CTL\/P2422 (unpublished data),"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1081\/DCT-120014798"},{"key":"CIT0061","volume-title":"Arcton 22 (Chlorodifluoromethane) Relationship between Blood Levels and Inhaled Concentrations in Anesthetised Artificially Ventilated Rats","author":"Carney I","year":"1977"},{"key":"CIT0062","first-page":"343","volume":"31","author":"Carpenter CP","year":"1949","journal-title":"J Ind Hyg Toxicol"},{"key":"CIT0063","volume-title":"Effects of Inhalation of Freon 113 on Laboratory Animals","author":"Carter VL","year":"1970"},{"key":"CIT0064","first-page":"212","volume":"13","author":"Clark DG","year":"1972","journal-title":"Proc Eur Soc Study Drug Toxic"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1177\/096032718200100306"},{"key":"CIT0066","first-page":"459","volume":"20","author":"Clayton JW","year":"1966","journal-title":"Handb Exp Pharmakol"},{"key":"CIT0067","first-page":"97","volume":"1","author":"Clayton JW","year":"1967","journal-title":"Fluorine Chem Rev"},{"key":"CIT0068","volume-title":"LC50 of G124 in Rats","author":"Coate WB","year":"1976"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/25.2.271"},{"key":"CIT0070","volume-title":"HCFC 123\u201313-Week Inhalation Neurotoxicity Study in the Rat","author":"Coombs DW","year":"1984"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1016\/0004-6981(76)90170-0"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1042\/bj1300087Pa"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1042\/bj1300013Pb"},{"key":"CIT0074","unstructured":"Culik R, Kelly DP. 1980. Embryotoxicity and Teratogenicity Studies in Rats with 1,1-Dichloroethane. Newark, DE.: Haskell Laboratory, E.I. du Pont de Nemours & Co. (HFC-152a) (unpublished report 437-79)."},{"key":"CIT0075","unstructured":"Damske DR, Mecler FJ, Beliles RP. 1978. Teratology Study in Rats; Isotron 142b. Monochlorodifluoroethane. England: Litton Bionetics, Kensington, MD, for ICI, Macclesfield. Final Report, LBI Proj. No. 20980."},{"key":"CIT0076","volume-title":"In Vitro Assessment of the Clastogenic Activity of HCFC 123 in Cultured Human Lymphocytes, Final Report","author":"Dance CA","year":"1991"},{"key":"CIT0077","volume-title":"An Acute Inhalation Toxicity Study of Fluorocarbon 123 in the Chinese Hamster, Corporate Medical Affairs Rep. No. MA-25-78-15","author":"Darr RW","year":"1981"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1002\/qua.560100720"},{"key":"CIT0079","volume-title":"Health Based Recommended Occupational Exposure Limits for Fluorocarbons","author":"DEC","year":"1987"},{"key":"CIT0080","volume-title":"Metabolism of 1,1-Dichloro-2,2,2-Trifluoroethane (personal communication)","author":"Dekant W","year":"1984"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.96104s175"},{"key":"CIT0082","first-page":"381","volume":"29","author":"Desoille H","year":"1968","journal-title":"I Arch Mal Prof M\u00e9d Trav S\u00e9cur Soc"},{"key":"CIT0083","first-page":"117","volume":"34","author":"Desoille H","year":"1973","journal-title":"Arch Mal Prof Med Trav Secur Soc"},{"key":"CIT0084","first-page":"151. H","volume-title":"Maximale Arbeitsplatzkonzentrationen und Biologische Arbeitsstofftoleranzwerte, D-6940","author":"DFG.","year":"1989"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(93)90117-G"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1080\/089583797198303"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(75)90086-4"},{"key":"CIT0088","unstructured":"Du Pont. 1995. Inhalation Developmental Toxicity Study of HFC-236fa in Rats, Newark (DE): Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 66\u201395 (unpublished data)."},{"key":"CIT0089","unstructured":"Du Pont. 1996. Inhalation Developmental Toxicity Study HFC-236fa in Rabbits, Newark (DE): Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 417-96 (unpublished data)."},{"key":"CIT0090","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). 1991. Joint Assessment of Commodity Chemicals, No. 17, 1-Chloro-1, 1-Difluoromethane. Brussels, Belgium: ECETOC."},{"key":"CIT0091","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). 1994a. Joint Assessment of Commodity Chemicals, No. 25, 1-Chloro-1,2,2,2-Tetrafluoroethane. Brussels, Belgium: ECETOC."},{"key":"CIT0092","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). 1994b. Joint Assessment of Commodity Chemicals, No. 29, 1-1-Dichloro-1-Fluoroethane. Brussels, Belgium: ECETOC."},{"key":"CIT0093","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). 1994c. Joint Assessment of Commodity Chemicals, No. 24: Pentafluoroethane (HFC 125). Brussels, Belgium: ECETOC."},{"key":"CIT0094","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). 1995a. Joint Assessment of Commodity Chemicals, No. 32: Difluoromethane. Brussels, Belgium: ECETOC."},{"key":"CIT0095","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). 1995b. Joint Assessment of Commodity Chemicals, No. 31: 1,1,1,2-Tetrafluoroethane. Brussels, Belgium: ECETOC."},{"key":"CIT0403","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) 1995a. Joint Assessment of Commodity Chemicals, No. 31: 1,1,1,2-Tetrafluoroethane. Brussels, Belgium: ECETOC."},{"key":"CIT0404","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). 1995b. Joint Assessment of Commodity Chemicals, No. 32: Difluoromethane. Brussels, Belgium: ECETOC."},{"key":"CIT0096","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). 1996. Joint Assessment of Commodity Chemicals, No. 33, 1-1-Dichloro-2,2,2-Trifluoroethane. Brussels, Belgium: ECETOC."},{"key":"CIT0097","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). 2005. Joint Assessment of Commodity Chemicals, No. 47, 1-1-Dichloro-2,2,2-Trifluoroethane. Brussels, Belgium: ECETOC."},{"key":"CIT0098","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). 2006. Joint Assessment of Commodity Chemicals, No. 52, 1,1,1-Trifluoroethane. Brussels, Belgium: ECETOC."},{"key":"CIT0099","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). 2008. Toxicity of Possible Impurities and By-products in Fluorocarbon Products, Technical Report No. 103, ECETOC. Brussels, Belgium: ECETOC."},{"key":"CIT0100","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC). 2009. Evaluation of Cardiac Sensitization Test Methods, Technical Report No. 105, ECETOC. Brussels, Belgium: ECETOC."},{"key":"CIT0101","unstructured":"Eddy CW, Griffith FD. 1971. Metabolism of Dichlorodifluoromethane-C14 by Rats, presented at the American Industrial Hygiene Association Conference, Toronto, Canada, May 1971, American National Standards Institute, New York, and American Industrial Hygiene Association, Akron, OH."},{"key":"CIT0102","volume-title":"Health Risks with Exposure to Freons in (Swedish)","author":"Edling C","year":"1988"},{"key":"CIT0103","unstructured":"Edwards CN. 1991a. HCFC 123 (Vapour Phase): In Vitro Assessment of Clastogenic Activity in Cultured Human Lymphocytes. Suffolk, UK: Life Sciences Research, Eye. Final Rep. No. 91\/PFE002\/0125."},{"key":"CIT0104","unstructured":"Edwards CN. 1991b. In Vitro Assessment of the Clastogenic Activity of HCFC 124 in Cultured Chinese Hamster Ovary (CHO-K1) Cells. Suffolk, UK: Life Sciences Research, Eye. Final Rep. No. 91\/PAR002\/0855a."},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700220607"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.3109\/00498259309166779"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1177\/096032719601500707"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1996.0096"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2009.11.005"},{"key":"CIT0110","first-page":"14","volume":"70","author":"Ember LR","year":"1996","journal-title":"Chem Eng News"},{"key":"CIT0111","unstructured":"Emmens H. 1999a. Report on an Ascending Dose Safety Study Comparing HFA-134a with CFC-12 and Air-Administered by Whole-Body Exposure to Health, Volunteers (unpublished data), Zeist, The Netherlands: TNO Nutrition and Food Research Institute. TNO. Rep. V98.754."},{"key":"CIT0112","unstructured":"Emmens H. 1999b. Report on an Ascending Dose Safety Study Company HFA-227 with CFC-12 and Air, Administered by Whole-Body Exposure to Healthy Volunteers. The Netherlands: TNO Nutrition and Food Research Institute. TNO Rep. V98.755."},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp273"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1038\/214526a0"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(72)90192-5"},{"key":"CIT0116","unstructured":"Emergency Response Planning Guide Committee (ERPG). 2012a. Emergency Response Planning Guidelines. 2,3,3,3-Tetrafluoropropene. Falls Church (VA): AIHA Guideline Foundation."},{"key":"CIT0117","unstructured":"Emergency Response Planning Guide Committee (ERPG). 2012b. Trans-1,3,3,3-tetrafluoropropene. Emergency Response Planning Guidelines. Falls Church (VA): AIHA Guideline Foundation."},{"key":"CIT0118","unstructured":"Emergency Response Planning Guide Committee (ERPG). 2014. Emergency Response Planning Guide: 1-Chloro-1, 1-Difluoroethane. Farifax, VA: AIHA- American Industrial Hygiene Association."},{"key":"CIT0119","unstructured":"Emergency Response Planning Guide Committee (ERPG). 2017. Emergency Response Planning Guide: 1,1-Dichloro-2,2,2-Trifluoroethane. Farifax, VA: AIHA- American Industrial Hygiene Association."},{"key":"CIT0120","unstructured":"Emergency Response Planning Guide Committee (ERPG). 2018. Emergency Response Planning Guide: 1,1-Difluoroethane. Farifax, VA: AIHA- American Industrial Hygiene Association."},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1038\/315207a0"},{"key":"CIT0122","unstructured":"Ferrara R. 1995. Reductive activation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123) by rat liver microsomal cytochrome P-450. 5th International Symposium for Biological Reactions Intermediates. Munich, Germany."},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.8064"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1975.10666719"},{"key":"CIT0125","first-page":"619","volume":"20","author":"Flowers NC","year":"1972","journal-title":"Clin Res"},{"key":"CIT0126","first-page":"671","volume":"114","author":"Fogel S","year":"1976","journal-title":"Can Med Assoc J"},{"key":"CIT0127","volume-title":"Allied Chemical Corp. from G. E. Foll","author":"Foll GE","year":"1976"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(74)90028-0"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1016\/0045-6535(93)90251-Y"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(73)90041-3"},{"key":"CIT0131","first-page":"1201","volume":"94","author":"Furuya M","year":"1979","journal-title":"Tokyo Jikeikai Ika Daigaku Zasshi"},{"key":"CIT0132","unstructured":"Gardner JR. 1988. Acute Dermal Toxicity to Rats of Dichlorofluoroethane, Huntingdon, Cambridgeshire, UK: Huntingdon Research Centre. Rep. No. 881114\/PWT91\/AC."},{"key":"CIT0133","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(89)90137-3"},{"key":"CIT0134","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(86)90196-1"},{"key":"CIT0135","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(74)90029-2"},{"key":"CIT0136","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0090-9556(25)07416-1","volume":"21","author":"Godin CS","year":"1993","journal-title":"Drug Metab Dispos"},{"key":"CIT0137","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(79)90064-2"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5539.563"},{"key":"CIT0139","first-page":"338","volume":"72","author":"Gunnare S","year":"2003","journal-title":"Toxicol Sci"},{"key":"CIT0140","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2006.08.009"},{"key":"CIT0141","first-page":"185","volume":"84","author":"Gunnare S","year":"2005","journal-title":"Toxicol Sci"},{"key":"CIT0142","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2007.05.005"},{"key":"CIT0143","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/30.8.638"},{"key":"CIT0144","unstructured":"Hall GT. 1975. Acute Inhalation Toxicity of Freon 123. Newark, DE.: Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 426-75."},{"key":"CIT0145","unstructured":"Hamner Institute for Health Sciences. 2007. Toxicogenomic Assessment of the carcinogenic potential. Of 2,3,3,3-tetrafluoropropene. Research Triangle Park, NC: The Hamner Institute for Health Sciences. Report no. 06014."},{"key":"CIT0146","first-page":"6","volume":"51","author":"Hanst PL","year":"1978","journal-title":"Chemistry"},{"key":"CIT0147","unstructured":"Hardy CJ. 1989. HCFC 141b Acute Inhalation Toxicity Study in Rats, 4-Hour Exposure. Huntingdon, Cambridgeshire, UK: Huntingdon Research Centre. Rep. No. PWT95\/881676."},{"key":"CIT0148","volume-title":"Hydrofluorocarbon 32: Assessment of Cardiac Sensitisation Potential in Beagle Dogs","author":"Hardy CJ","year":"1992"},{"key":"CIT0149","unstructured":"Hardy CJ, Sharman IJ, Clark GC. 1991. Assessment of Cardiac Sensitization in Dogs, Comparison of HFA 134a and A12, CTL. Huntingdon, Cambridgeshire, UK: Huntingdon Research Centre. Rep. No. CTL\/C\/2521, ICI, CTL."},{"key":"CIT0150","doi-asserted-by":"publisher","DOI":"10.1021\/tx00029a020"},{"key":"CIT0151","doi-asserted-by":"publisher","DOI":"10.1021\/tx00020a009"},{"key":"CIT0152","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90096-N"},{"key":"CIT0153","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/01.CIR.44.1.119","volume":"44","author":"Harriset WS","year":"1971","journal-title":"Circulation"},{"key":"CIT0154","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1996.tb05980.x"},{"key":"CIT0155","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.1989.tb00492.x"},{"key":"CIT0156","unstructured":"Henschler D. 1987. Gesundheitsschadliche Arbeitstoffe, Toxikologisch-arbeitsmedizinische, Begrundung von MAK-Werten, No. 12, VCH Verlag."},{"key":"CIT0157","unstructured":"Hino Y, Yamasaki K, Schiraishi K. 1992. Twenty Eight-Day Repeated Inhalation Toxicity Study of HCFC 141b in Rats. OITA, Japan: Hita Research Laboratory Chemical Biotesting Center, Chemicals Inspection and Testing Institute. Rep. B 18-0005."},{"key":"CIT0158","doi-asserted-by":"publisher","DOI":"10.1002\/rog.20013"},{"key":"CIT0159","unstructured":"Hodson-Walker G. 1990. In Vitro Assessment of the Clastogenic Activity of HCFC141b in Cultured Chinese Hamster Ovary (CHO-K1) Cells. Suffolk, UK: Life Sciences Research, Eye. LSR Rep. 89\/PFG001\/0971a."},{"key":"CIT0160","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)03094-8"},{"key":"CIT0161","unstructured":"Honeywell. 2011. HFO-1234ze Material Safety Data Sheet, Morristown NJ."},{"key":"CIT0162","first-page":"39","volume":"15","author":"Horiguchi Y","year":"1985","journal-title":"Bull\u2014Kanagawa Prefect Public Health Lab"},{"key":"CIT0163","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1992.tb17042.x"},{"key":"CIT0164","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80030-0"},{"key":"CIT0165","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1972.10666080"},{"key":"CIT0167","unstructured":"Intergovernmental Panel on Climate Change (IPCC). 1990. International Program for Chemical Safety. Fully Halogenated Chlorofluorocarbons, Environmental Health Criteria 113. Geneva: World Health Organization."},{"key":"CIT0168","unstructured":"Intergovernmental Panel on Climate Change (IPCC). 1992. International Program for Chemical Safety. Partially Halogenated Chlorofluorocarbons, Environmental Health Criteria 139, 2PCS. Geneva: World Health Organization."},{"key":"CIT0166","unstructured":"Intergovernmental Panel on Climate Change (IPCC). 1994. Radiative Forcing of Climate Change 1994. The 1994 Report of the Scientific Assessment Working Group of IPCC, Summary of Policymakers, IPCC. Geneva: World Health Organization."},{"key":"CIT0169","volume-title":"Toxicometric Parameters of Industrial Toxic Chemicals under Single Exposure","author":"Izmerov NF","year":"1982"},{"key":"CIT0170","unstructured":"Jack D. (1971) Allen & Hanburys Ltd., An Investigation of Possible Cardiotoxic Effects of the Aerosol, Propellants, Arctons 11 and 12, Vol. 1, unpublished report, courtesy of D. Jack, Managing Director, Allen & Hanburys Ltd."},{"key":"CIT0171","volume-title":"Mutagenic Evaluation of Isotron 142b","author":"Jagannath DR","year":"1977"},{"key":"CIT0172","volume-title":"Acute Dermal Toxicity Study with FC 141b in Rats, Interim Doc. No. 56645\/23\/88","author":"Janssen PJM","year":"1988"},{"key":"CIT0173","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90903-0"},{"key":"CIT0174","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(70)90169-9"},{"key":"CIT0175","doi-asserted-by":"publisher","DOI":"10.1038\/292823a0"},{"key":"CIT0176","doi-asserted-by":"publisher","DOI":"10.1016\/S0380-1330(83)71890-3"},{"key":"CIT0177","first-page":"231","volume":"75","author":"Karpov BD","year":"1963","journal-title":"Tr Leningr Sanit Gig Med Inst"},{"key":"CIT0178","first-page":"128","volume":"75","author":"Karpov BD","year":"1963","journal-title":"Tr Leningr Sanit-Gig Med Inst"},{"key":"CIT0179","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700250512"},{"key":"CIT0180","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1995.1163"},{"key":"CIT0181","unstructured":"Kehoe RA. 1943. Report on Human Exposure to Dichlorodifluoromethane in Air, unpublished report. Cincinnati, OH: Kettering Laboratory."},{"key":"CIT0182","volume-title":"Metabolism of HFC-143a in the Rat, unpublished report HLR 3-94","author":"Keller DA","year":"1994"},{"key":"CIT0183","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1996.0058"},{"key":"CIT0185","unstructured":"Kelly DP. 1978. Inhalation teratology studies on three fluorocarbons. Toxicol Appl Pharmacol. 45:293."},{"key":"CIT0184","unstructured":"Kelly DP. 1990. Four-Hour Inhalation Approximate Lethal Concentration (ALC) of HCFC-124 in Rats. Newark (DE): Haskell Laboratory, E.I. du Pont de Nemours Co. Rep. No. 71-90."},{"key":"CIT0186","unstructured":"Kelly DP, Trochimowicz HJ. 1976. Two-Week Inhalation Toxicity Studies FC21 and FC 123. Newark, DE: Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 149-76."},{"key":"CIT0187","unstructured":"Kennedy GL. 1979. Acute Inhalation Toxicity Study of Tetrafluoroethane (FC 134a), Newark, DE: Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 422-79."},{"key":"CIT0188","unstructured":"Kennelly JC. 1993. Assessment for the Induction of Unscheduled DNA Synthesis in Rat Liver After Inhalation Exposure. Cheshire, UK: Zeneca Central Toxicology Laboratory, Alderley Park, Macclesfield."},{"key":"CIT0189","doi-asserted-by":"publisher","DOI":"10.1029\/1998JD100097"},{"key":"CIT0190","unstructured":"Koops A, Krahn DF. 1977. Mutagenic Activity of Ethane Chlorodifluoro in the Salmonella\/Microsome Assay. Newark, DE.: Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 578-77."},{"key":"CIT0191","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0090-9556(25)07452-5","volume":"24","author":"Koster U","year":"1996","journal-title":"Drug Metab Dispos"},{"key":"CIT0192","unstructured":"Krahn DF. 1977. Mutagenic Activity of Methane, Chlorodifluoro, in the Salmonella Microsome Assay. Newark, DE: Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 577-77."},{"key":"CIT0193","first-page":"91","volume":"25","author":"Krahn DF","year":"1982","journal-title":"Environ Sci Res"},{"key":"CIT0194","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-015-9348-5"},{"key":"CIT0195","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-100102469"},{"key":"CIT0196","doi-asserted-by":"publisher","DOI":"10.1038\/344529a0"},{"key":"CIT0197","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0489"},{"key":"CIT0198","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-0590(81)80126-1"},{"key":"CIT0199","first-page":"1270","volume":"171","author":"Lessard Y","year":"1977","journal-title":"C. R. Seances Soc Biol Ses Fil"},{"key":"CIT0200","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/20.11.807"},{"key":"CIT0201","first-page":"335","volume":"2","author":"Lester D","year":"1950","journal-title":"Arch Ind Hyg Occup Med"},{"key":"CIT0202","first-page":"1475","volume":"33","author":"Leuschner F","year":"1983","journal-title":"Arzneimittelforschung"},{"key":"CIT0203","doi-asserted-by":"publisher","DOI":"10.1021\/es60110a005"},{"key":"CIT0204","doi-asserted-by":"publisher","DOI":"10.2190\/M1NT-3PCH-DWNN-8NH7"},{"key":"CIT0205","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(84)90331-4"},{"key":"CIT0206","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0090-9556(25)07507-5","volume":"22","author":"Loizou GD","year":"1994","journal-title":"Drug Metab Dispos"},{"key":"CIT0207","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S0090-9556(25)07466-5","volume":"21","author":"Loizou GD","year":"1993","journal-title":"Drug Metab Dispos"},{"key":"CIT0208","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0090-9556(25)06671-1","volume":"23","author":"Loizou GD","year":"1995","journal-title":"Drug Metab Dispos"},{"key":"CIT0209","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(84)90245-X"},{"key":"CIT0210","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(78)90056-5"},{"key":"CIT0211","unstructured":"Lu M. 1981. 1,1,1,2-Tetrafluoroethane (FC-134a): embryo-foetal toxicity and teratogenicity study by inhalation in the rat. Newark, DE: Newark, DE.: Haskell Laboratory, E.I. du Pont de Nemours & Co. (unpublished data)."},{"key":"CIT0212","volume-title":"HCFC 123: An Evaluation in the In Vitro Cytogenetic Assay","author":"Mackay JM","year":"1992"},{"key":"CIT0213","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2003.09.008"},{"key":"CIT0214","volume-title":"1,1,1,2-Tetrafluoethan Toxikolgisch-Arbeits Medizinsche","author":"MAK","year":"1996"},{"key":"CIT0215","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1996.0197"},{"key":"CIT0216","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1995.1044"},{"key":"CIT0217","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1996.0102"},{"key":"CIT0218","doi-asserted-by":"publisher","DOI":"10.3109\/01480549809002215"},{"key":"CIT0219","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb30116.x"},{"key":"CIT0220","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb50389.x"},{"key":"CIT0221","first-page":"68, 70, 92, 99","volume":"10","author":"Marier G","year":"1973","journal-title":"Household Pers Prod Ind"},{"key":"CIT0222","doi-asserted-by":"publisher","DOI":"10.1177\/019262339402200406"},{"key":"CIT0223","volume-title":"Evaluation of chromosomal aberration frequencies in peripheral blood lymphocytes from rats treated with HCFC 123","author":"Marshall RR","year":"1992"},{"key":"CIT0224","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1984.10545862"},{"key":"CIT0225","unstructured":"McAlack JW, Schneider PW. 1982. Two-Year Inhalation Study with 1,1-Difluoroethane (FC 152a) in Rats (unpublished report 8-82). Newark, DE: Haskell Laboratory, E.I. du Pont de Nemours & Co."},{"key":"CIT0226","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(72)90172-X"},{"key":"CIT0227","unstructured":"McCooey KT. 1980. Methane Dichlorodifluoro, Chinese Hamster Ovary Cell Assay for Mutagenicity. Newark, DE: Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 149-90."},{"key":"CIT0228","first-page":"447","volume":"15","author":"McKnight JE","year":"1983","journal-title":"J Submicrosc Cytol"},{"key":"CIT0229","volume-title":"Acute Inhalation Toxicity Study in Rat. Isotron 142b, LBI Proj. No. 20888","author":"Mecler FJ","year":"1978"},{"key":"CIT0230","unstructured":"Mercier O. 1990a. HFA-134a: Test to Evaluate the Ocular Irritation in the Rabbit. La Defense Paris: Hazleton, France for Elf Atochem. Rep. No. 912349."},{"key":"CIT0231","unstructured":"Mercier O. 1990b. HFA-134a: Test to Evaluate the Sensitizing Potential by Topical Applications in the Guinea Pig. The Epicutaneous Maximization Test. La Defense Paris: Hazleton, France for Elf Atochem. Rep. No. 001380."},{"key":"CIT0232","unstructured":"Mercier O. 1989. HFA-134a: Test to Determine the Index of Primary Cutaneous Irritation in the Rabbit. Paris: Hazleton, France for Elf Atochem, La Defense. Rep. No. 911422."},{"key":"CIT0233","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197503000-00018"},{"key":"CIT0234","volume-title":"Results of Employee Exposure Monitoring for HCFC 123 at Centrifugal Chiller Installations, Final Report 68-D90068","author":"Meridian","year":"1991"},{"key":"CIT0235","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(95)00015-T"},{"key":"CIT0236","first-page":"315","volume":"96","author":"Millischer RJ","year":"2007","journal-title":"Toxicologist"},{"key":"CIT0237","doi-asserted-by":"publisher","DOI":"10.1038\/249810a0"},{"key":"CIT0238","doi-asserted-by":"publisher","DOI":"10.1016\/0731-7085(94)00104-9"},{"key":"CIT0239","unstructured":"Moore BL. 1975. Acute Inhalation Toxicity (unpublished report 699-75). Newark, DE: Haskell Laboratory, E.I. du Pont de Numours & Co."},{"key":"CIT0240","unstructured":"Moore BL, Trochimowicz HJ. 1976. Subacute (Two-Week) Inhalation Toxicity. Newark, DE.: Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 145-76."},{"key":"CIT0241","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e318159a3b6"},{"key":"CIT0242","doi-asserted-by":"publisher","DOI":"10.1016\/0020-708X(72)90076-2"},{"key":"CIT0243","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9432(77)90027-9"},{"key":"CIT0245","volume-title":"HCFC 123\u2014Micronucleus Test in Male and Female NMRI Mice after Inhalation","author":"Muller W","year":"1988"},{"key":"CIT0244","volume-title":"CFC 134a: Micronucleus Test in Male and Female NMRI Mice after Inhalation","author":"Muller W","year":"1989"},{"key":"CIT0246","unstructured":"Mullin LS. 1969. (unpublished data). Newark, DE: Haskell Laboratory, E.I. du Pont de Nemours & Co."},{"key":"CIT0247","unstructured":"Mullin LS. 1976. Cardiac Sensitization. Newark, DE.: Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 113-76."},{"key":"CIT0248","unstructured":"Mullin LS. 1977. Cardiac Sensitization (HFA 141b), Newark, DE.: Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 957-77."},{"key":"CIT0249","unstructured":"Mullin LS. 1979. FC 134a: Cardiac Sensitization. Newark, DE.: Haskell Laboratory, E.I. du Pont de Nemours & Co."},{"key":"CIT0250","doi-asserted-by":"publisher","DOI":"10.1080\/0002889728506670"},{"key":"CIT0251","volume-title":"Climate Change 2013: The Physical Science Basis. Contribution of Working Group I to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change","author":"Myhre G, D","year":"2013"},{"key":"CIT0252","volume-title":"Present State of Knowledge of the Upper Atmosphere: An Assessment Report","author":"National Aeronautics and Space Administration NASA.","year":"1986"},{"key":"CIT0253","volume-title":"Bioassay of Trichlorofluoromethane for Possible Carcinogenicity, Case No. 75-69-4, NCI Carcinoa. Tech. Rep. Ser. No. 106, NTIS Pub. No. PB-286-187","author":"NCI","year":"1978"},{"key":"CIT0254","first-page":"420","volume":"49","author":"Nemec M","year":"1994","journal-title":"Teratology"},{"key":"CIT0255","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600640507"},{"key":"CIT0256","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600660111"},{"key":"CIT0257","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2007.03.053"},{"key":"CIT0258","first-page":"37","volume":"9","author":"Nikitenko TK","year":"1965","journal-title":"Gig Tr Prof Zabol"},{"key":"CIT0259","unstructured":"National Institute for Occupational Safety and Health (NIOSH). 1980. Health Hazard Evaluation Determination. NIOSH: Cincinnati, OH. Rep. No. 79-127-644, NTIS PB 80-169816."},{"key":"CIT0261","unstructured":"Nuckolls AH. 1993. The Comparative Life, Fire, and Explosion Hazards of Common Refrigerants, Misc. Hazard No. 2375. Chicago, IL: Underwriters Laboratories; p. 5\u20139, 24\u201326, 57\u201361, 106\u2013107."},{"key":"CIT0262","unstructured":"OECD www.oecd-library.org\/environment\/oecd-guidelines-for-the-testing-of-chemicals-section-4-health-effects"},{"key":"CIT0263","volume-title":"Oxidation of 1,1,1,2-Tetrafluoroethane (R-134a) in Rat Live Microsomes is Catalyzed Primarily by Cytochrome P45011E1","author":"Olson MJ","year":"1990"},{"key":"CIT0264","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S0090-9556(25)08958-5","volume":"19","author":"Olson MJ","year":"1991","journal-title":"Drug Metab Dispos"},{"key":"CIT0265","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)91021-J"},{"key":"CIT0267","volume-title":"Effect of Arcton 22 on Pregnant Rats: Relationship to Anophthalmia and Microphthalmia","author":"Palmer AK","year":"1978"},{"key":"CIT0268","volume-title":"Effect of Arcton 22 on Pregnancy of the New Zealand White Rabbit","author":"Palmer AK","year":"1978"},{"key":"CIT0269","first-page":"255","volume":"22","author":"Pantaleoni GC","year":"1975","journal-title":"Rass Med Sper"},{"key":"CIT0270","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)92149-0"},{"key":"CIT0271","doi-asserted-by":"publisher","DOI":"10.5194\/acp-10-10867-2010"},{"key":"CIT0272","first-page":"74","volume":"180","author":"Paulet G","year":"1969","journal-title":"Labo-Pharma Probl Tech"},{"key":"CIT0273","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(75)90025-3"},{"key":"CIT0274","first-page":"251","volume":"30","author":"Paulet G","year":"1969","journal-title":"Arch Mal Prof M\u00e9d Trav Secur Soc"},{"key":"CIT0275","first-page":"477","volume":"30","author":"Paulet G","year":"1969","journal-title":"Arch Mal Prof M\u00e9d Trav Secur Soc"},{"key":"CIT0276","doi-asserted-by":"publisher","DOI":"10.1007\/BF00297122"},{"key":"CIT0277","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/S0090-9556(25)06665-6","volume":"23","author":"Pike VW","year":"1995","journal-title":"Drug Metab Dispos"},{"key":"CIT0278","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.28.040188.002055"},{"key":"CIT0279","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(67)90110-X"},{"key":"CIT0280","first-page":"14","volume":"20","author":"Quevauviller A","year":"1965","journal-title":"Prod Probl Pharm"},{"key":"CIT0281","first-page":"247","volume":"19","author":"Quevauviller A","year":"1964","journal-title":"Th\u00e9rapie"},{"key":"CIT0282","doi-asserted-by":"publisher","DOI":"10.1007\/BF00377665"},{"key":"CIT0283","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/37.10.716"},{"key":"CIT0284","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1971.10665840"},{"key":"CIT0285","doi-asserted-by":"publisher","DOI":"10.1080\/0002889718506428"},{"key":"CIT0286","first-page":"953","volume":"15","author":"Reinhardt CF","year":"1973","journal-title":"J Occup Med"},{"key":"CIT0287","unstructured":"Rickard LB. 1990. Mouse Bone Marrow Micronucleus Assay of HCFC-124. Newark (DE): Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 52-90."},{"key":"CIT0288","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-813X(01)00011-0"},{"key":"CIT0289","first-page":"281","volume":"19","author":"Rowland FS","year":"1990","journal-title":"Ambio"},{"key":"CIT0290","unstructured":"Rusch GM. 1990. Results from the Program for Alternative Fluorocarbon Toxicology Testing Activities: DECHEMA DCKW-Ausstieg Wohin? (CFC Phaseout Whereto?). Frankfurt Germany: DECEMA; p. 245\u2013261."},{"key":"CIT0291","unstructured":"Rusch GM. 2002. Organic chlorofluoro hydrocarbons. In: Bingham E, Cohrssen B, editors. Patty\u2019s toxicology. Chapter 46, Vol. 3. Hoboken (NJ): John Wiley & Sons. p. 359\u2013427."},{"key":"CIT0294","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/52.2.289"},{"key":"CIT0292","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(94)00144-D"},{"key":"CIT0293","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1994.1095"},{"key":"CIT0295","doi-asserted-by":"publisher","DOI":"10.3109\/01480545.2012.661738"},{"key":"CIT0296","first-page":"113","volume":"4","author":"Russe BR","year":"1980","journal-title":"Chem Depend Behav Biomed Issues"},{"key":"CIT0297","first-page":"307","volume":"2","author":"Russell JF","year":"1980","journal-title":"Environ Mutagen"},{"key":"CIT0298","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(81)90453-1"},{"key":"CIT0299","volume-title":"Arcton 22: Metabolism Study In Vivo in Rats and In Vitro","author":"Salmon AG","year":"1979"},{"key":"CIT0300","first-page":"305","volume":"42","author":"Salmon AG","year":"1985","journal-title":"Br J Ind Med"},{"key":"CIT0301","unstructured":"Sandow J. 1996. Effect of Fluorocarbons on Pituitary-Gonadal Function in a 14-Day Inhalation Toxicity Study\u2014HCFC 123. Hoechst Study No. 95.0089 (unpublished data), Hoechst A. G. Kastengrund, Germany."},{"key":"CIT0302","unstructured":"Sarver JW. 1988. Acute Oral Toxicity Study with FC-141b Male Rats. Newark, DE.: Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. HRL 363-88, E.I."},{"key":"CIT0303","volume-title":"Toxicity of Dichlorofluoromethane: A New Refrigerant, Rep. Invest. No. 3013","author":"Sayers RR","year":"1930"},{"key":"CIT0304","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.05.019"},{"key":"CIT0305","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.02.004"},{"key":"CIT0306","doi-asserted-by":"publisher","DOI":"10.1021\/j100137a023"},{"key":"CIT0307","first-page":"420","volume":"4","author":"Scholz J","year":"1962","journal-title":"Fortschr Biol Aerosol Forsch Jahren 1957\u20131961"},{"key":"CIT0308","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.06.018"},{"key":"CIT0309","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.12.022"},{"key":"CIT0310","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(86)90234-6"},{"key":"CIT0311","unstructured":"Sherman H. 1974. Long-Term Feeding Studies in Rats and Dogs with Dichlorodifluoromethane (Freon 12 Food Freezant). Newark (DE): Haskell Laboratory, E.I. du Pont de Nemours & Co. Med. Res. Proj. No. 1388. Rep. No. 24-74, unpublished."},{"key":"CIT0312","first-page":"629","volume":"46","author":"Shulman M","year":"1967","journal-title":"Anesth Analg"},{"key":"CIT0313","doi-asserted-by":"publisher","DOI":"10.1126\/science.203.4383.899"},{"key":"CIT0314","doi-asserted-by":"publisher","DOI":"10.1029\/JC088iC06p03675"},{"key":"CIT0315","first-page":"99","volume-title":"Halon Properties","author":"Skaggs SR","year":"1995"},{"key":"CIT0316","doi-asserted-by":"publisher","DOI":"10.1007\/BF00539131"},{"key":"CIT0317","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(65)90074-2"},{"key":"CIT0318","doi-asserted-by":"publisher","DOI":"10.3109\/01480548209041059"},{"key":"CIT0401","unstructured":"SORG. 1987. Stratospheric Ozone Review Group, Stratospheric Ozone 1987. London: HMSO Publications Centre."},{"key":"CIT0319","volume-title":"Stratospheric Ozone Review Group, Stratospheric Ozone 1993","author":"SORG.","year":"1993"},{"key":"CIT0320","unstructured":"SPARC. 2013. Report on the Lifetimes of Stratospheric Ozone-Depleting Substances, Their Replacements, and Related Species. In: M. Ko, P. Newman, S. Reimann, S. Strahan, editors. German Aerospace Center, Institut Fur Physik der Atmosphare, Muchener Strasse 20, D-82234 Oberpfaffenhofen, Germany. SPARC Report No. 6, WCRP-15\/2013."},{"key":"CIT0321","volume-title":"1,1,1,2-Tetrafluoroethane HFC 134a Criteria Doc. for an Occupational Exposure Limit","author":"Standing P","year":"1995"},{"key":"CIT0322","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7826275"},{"key":"CIT0323","doi-asserted-by":"publisher","DOI":"10.1080\/00028896709342484"},{"key":"CIT0324","first-page":"77","volume":"90","author":"Szmidt M","year":"1981","journal-title":"Acta Soc Med. Svec Hyg"},{"key":"CIT0325","doi-asserted-by":"publisher","DOI":"10.1539\/joh.40.169"},{"key":"CIT0326","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0022-3565(25)30038-8","volume":"192","author":"Taylor GJ","year":"1974","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0327","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1970.03180010023004"},{"key":"CIT0328","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106640"},{"key":"CIT0329","volume-title":"Report of Worker Exposure to HCFC 123 During Servicing of Hermetic Centrifugal Chillers","author":"The Trane Company.","year":"1992"},{"key":"CIT0330","first-page":"105","volume":"15","author":"Thomas G","year":"1965","journal-title":"Trans Assoc Ind Med off"},{"key":"CIT0331","unstructured":"Thomas R. 2007. Toxicogenomic Assessment of the Carcinogenic Potential of HFO-1234ze. Report 06014. Study conducted by Honeywell International by The Hamner Institute, Research Triangle Park, NC. Ref. MA-RR-07-3453."},{"key":"CIT0332","volume-title":"Chlorodifluoromethane (CFC 22): Long-Term Inhalation Study in the Mouse","author":"Tinston DJ","year":"1981"},{"key":"CIT0333","volume-title":"Chlorodifluoromethane (CFC 22): Long-term Inhalation Study in the Rat","author":"Tinston DJ","year":"1981"},{"key":"CIT0334","unstructured":"TKL. 2010. Repeat Insult Patch Study. TKL Research Study Number DS 100410\u2009MA-RR-10-4300."},{"key":"CIT0335","unstructured":"TKL. 2012. Repeat Insult Patch Study. TKL Research Study Number 103122, [HCFO-1233zd (E)] MA-RR-12-4343."},{"key":"CIT0336","volume-title":"Documentation of the Threshold Limit Values and Biological Exposure Indices: Trichlorofluoromethane","author":"TLV.","year":"1991","edition":"6"},{"key":"CIT0337","unstructured":"TNO. 2008. A 2-Generation inhalation, reproduction study in Wistar rats with HFO-1234yf. Interim report TNO Quality of Life (conducted for Honeywell International) Zeist, The Netherlands."},{"key":"CIT0338","first-page":"711","volume":"26","author":"Tong Z","year":"1998","journal-title":"Drug Metab Dispos"},{"key":"CIT0340","volume-title":"Du Pont (personal communication)","author":"Trochimowicz HJ","year":"1978"},{"key":"CIT0341","volume-title":"The Toxicology of Fluorocarbon 113, presented to the Swedish Board of Occupational Safety and Health","author":"Trochimowicz HJ","year":"1984"},{"key":"CIT0345","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(88)90271-0"},{"key":"CIT0342","unstructured":"Trochimowicz HJ. 1989. The Toxicology of HCFC-123 (2,2-Dichloro-1,1,1-Trifluoro-Ethane), presented at the 1989 European Meeting of the Toxicology Forum, Toulouse, France, September 19\u201322."},{"key":"CIT0339","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(93)90115-E"},{"key":"CIT0343","first-page":"26","volume":"18","author":"Trochimowicz HJ","year":"1976","journal-title":"J Occup Med"},{"key":"CIT0344","doi-asserted-by":"publisher","DOI":"10.1080\/0002889748507083"},{"key":"CIT0346","first-page":"198","volume":"41","author":"Trochimowicz HJ","year":"1977","journal-title":"Toxicol Appl Pharmacol"},{"key":"CIT0347","unstructured":"Trochimowicz HJ, Mullin LS. 1973. Cardiac Sensitization of Fluorocarbon 123. Newark (DE): Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. 132-73, E.I."},{"key":"CIT0348","unstructured":"Trueman RW. 1990. Fluorocarbon 134a: Assessment for the Induction of Unscheduled DNA Synthesis in Rat Hepatocytes In Vivo. Cheshire, UK.: Imperial Chemical Industries, Central Toxicology Laboratory, Alderley Park. CTL Study No. SR0337."},{"key":"CIT0349","doi-asserted-by":"publisher","DOI":"10.3109\/01480545.2012.749273"},{"key":"CIT0350","doi-asserted-by":"publisher","DOI":"10.3109\/01480545.2013.806536"},{"key":"CIT0351","doi-asserted-by":"publisher","DOI":"10.3109\/00498257709035798"},{"key":"CIT0352","unstructured":"UNEP. 2014. Report of the Refrigeration, Air Conditioning and Heat Pumps Technical Options Committee, Lambert Kuijpers and Robert Peixoto (Co-chairs) Montreal Protocol Secretariat. Nairobi, Kenya: UNEP. 2015. ISBN: 978-9966-076-09-0."},{"key":"CIT0353","unstructured":"UNEP\/WMO. 1989. Scientific Assessment of Stratospheric Ozone: 1989, Sect. III, Ch. 4. Geneva: United Environment Programme, World Meteorological Organization. Report dated August 21, 1989."},{"key":"CIT0354","doi-asserted-by":"publisher","DOI":"10.1021\/tx00038a009"},{"key":"CIT0355","first-page":"291","volume":"30","author":"Valentine R","year":"1996","journal-title":"Toxicologist"},{"key":"CIT0356","first-page":"130","volume":"34","author":"Valic F","year":"1977","journal-title":"Ind Med"},{"key":"CIT0357","first-page":"229","volume":"402","author":"Valic F","year":"1982","journal-title":"Red Jazu"},{"key":"CIT0358","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7721121"},{"key":"CIT0359","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1976.tb02996.x"},{"key":"CIT0360","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(60)90002-8"},{"key":"CIT0361","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1994.1233"},{"key":"CIT0362","unstructured":"Vinegar A, Jepson GW, Overton JH. 1998. Inhalation of Halon 1301, HFC-134a, and HFC 227ea for Collection of Pharmacokinetic Data. Dayton, OH.: Mann. Tech Environmental Technology. Rep. NTIS\/AD-A329 1994\/4."},{"key":"CIT0363","unstructured":"Vinegar A, Jepson G. 1995. Gas Uptake Kinetics of 1,1,1,3,3,3-Hexafluoropropane (HFC-236fa) and Identification of Potential Metabolites. Dayten, OH.: Mann-Tech Environmental Technology. Rep. AL\/OE-TR-1995-0177 (unpublished data)."},{"key":"CIT0364","doi-asserted-by":"publisher","DOI":"10.1080\/08958370050085174"},{"key":"CIT0365","unstructured":"Vlachos DA. 1989. Mouse Bone Marrow Micronucleus Assay of FC-141b. Newark, DE.: Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. No. HRL 746-88."},{"key":"CIT0366","first-page":"1159","volume":"68","author":"Voge VM","year":"1997","journal-title":"Aviat Space Environ Med"},{"key":"CIT0367","first-page":"149","volume":"21","author":"von Weigand W","year":"1971","journal-title":"Zentralbl Arbeitsmed"},{"key":"CIT0368","volume-title":"Anesthetic Activity and Fatality (F-123, 123a, 124 and 11)","author":"Wada H","year":"1977"},{"key":"CIT0402","unstructured":"Wagner B, Anger WK, Feigley C, Generosa W, Graves I, Snyder R, Wogan G, Yost G. 1996. Subcommittee to review toxicity of alternatives to chlorofluorocarbons. In: Crossgrove R, editor. Toxicity of Alternatives to Chlorofluorocarbons: HFC 134a and HCFC 123. Washington (DC): National Academy Press. p. 13\u201321."},{"key":"CIT0369","unstructured":"Warheit DB. 1993. Mechanistic Studies with HCFC-123. Newark, DE.: Haskell Laboratory, E.I. du Pont de Nemours & Co. Rep. HLR 828-92 (unpublished data)."},{"key":"CIT0370","unstructured":"Waritz RS. 1971. Toxicology of Some Commercial Fluorocarbons. Springfield, VA: National Technical Information Service. NTIS; AD Rep. No. 751429,"},{"key":"CIT0371","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(75)90087-6"},{"key":"CIT0372","volume-title":"Workplace Environmental Exposure Level Guide: 1,1-Dichloro-1-Fluoroethane","author":"Workplace Environmental Exposure Level (WEEL).","year":"1991"},{"key":"CIT0373","volume-title":"Workplace Environmental Exposure Level Guide: 1-Chloro-1,1-Difluoroethane","author":"Workplace Environmental Exposure Level (WEEL).","year":"1994"},{"key":"CIT0374","volume-title":"Workplace Environmental Exposure Level Guide: 1,1,1-Trifluoroethane","author":"Workplace Environmental Exposure Level (WEEL).","year":"1996"},{"key":"CIT0375","volume-title":"Workplace Environmental Exposure Level Guide: 1,1-Dichloro-2,2,2-Trifluoroethane","author":"Workplace Environmental Exposure Level (WEEL).","year":"1998"},{"key":"CIT0376","volume-title":"Workplace Environmental Exposure Level Guide: 1,1,1,3,3,3-Hexafluoropropane","author":"Workplace Environmental Exposure Level (WEEL).","year":"1998"},{"key":"CIT0377","volume-title":"Workplace Environmental Exposure Level Guide: Tetrafluoroethane (HFC134a)","author":"Workplace Environmental Exposure Level (WEEL).","year":"2003"},{"key":"CIT0378","volume-title":"WEEL Guide 1-Chloro-1,2,2,2-Tetrafluoro-Ethane (HCFC 124)","author":"Workplace Environmental Exposure Level (WEEL).","year":"2005"},{"key":"CIT0379","volume-title":"Workplace Environmental Exposure Level Committee 2,3,3,3-tetrafluoropropene","author":"Workplace Environmental Exposure Level (WEEL).","year":"2009"},{"key":"CIT0380","volume-title":"Workplace Environmental Exposure Level Guide: 1,1,1,3,3-Pentafluorocarbons","author":"Workplace Environmental Exposure Level (WEEL).","year":"2009"},{"key":"CIT0381","volume-title":"Workplace Environmental Exposure Level Guide: Pentafluoroethane","author":"Workplace Environmental Exposure Level (WEEL).","year":"2009"},{"key":"CIT0382","unstructured":"Workplace Environmental Exposure Level (WEEL). 2012. Workplace Environmental Exposure Level Committee, 1,3,3,3-Tetrafluropropylene. OARS WEEL, Workplace Environmental Exposure Level, Cincinnati, OH."},{"key":"CIT0383","volume-title":"Workplace Environmental Exposure Level Guide: Difluoroethane","author":"Workplace Environmental Exposure Level (WEEL).","year":"2012"},{"key":"CIT0384","unstructured":"Workplace Environmental Exposure Level (WEEL). 2013. Workplace Environmental Exposure Level, trans-1-Chloro-3,3,3-trifluoro propene. OARS WEEL, Workplace Environmental Exposure Level, Cincinnati, OH."},{"key":"CIT0385","volume-title":"Workplace Environmental Exposure Level Guide: 1,1-Difluoroethane","author":"Workplace Environmental Exposure Level (WEEL).","year":"2018"},{"key":"CIT0386","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(81)90331-8"},{"key":"CIT0387","unstructured":"WIL. 1996. Research Laboratory (WIL), Acute Inhalation Toxicity Study of HFC-236fa in Albino Rats. Rep. WIL-189022. WIL: Ashland, OH."},{"key":"CIT0388","unstructured":"WMO. 1991a. World Meteorological Organization, Global Ozone Research and Monitoring Project. Geneva: WMO. Rep. No. 25"},{"key":"CIT0389","unstructured":"WMO. 1991b. World Meteorological Organization, Global Research and Monitoring Project. Geneva: WMO. Rep. No. 20. Vol. II, Appendix: AFEAS Report."},{"key":"CIT0391","volume-title":"World Meteorological Organization. 1998\u20131999 WMO Global Ozone Research and Monitoring Project","author":"WMO.","year":"1999"},{"key":"CIT0390","unstructured":"WMO. 2007. World Meteorological Association, Scientific Assessment of Ozone Depletion: 2006, Global Ozone Research and Monitoring Project. Geneva, Switzerland. Report No. 50. p. 572."},{"key":"CIT0392","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0026-895X(25)12433-4","volume":"13","author":"Wolf CR","year":"1977","journal-title":"Mol Pharmacol"},{"key":"CIT0393","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(78)90026-1"},{"key":"CIT0394","unstructured":"Woollen BH. 1988. Arcton 22: Pharmacokinetics in the Pregnant Female Rat Following Inhalation Exposure. CTL report number CTL\/L\/1982 (unpublished data), ICI Alderly Part, Cheshire, England."},{"key":"CIT0395","doi-asserted-by":"publisher","DOI":"10.1007\/BF00397851"},{"key":"CIT0396","doi-asserted-by":"publisher","DOI":"10.1007\/BF00379550"},{"key":"CIT0397","doi-asserted-by":"publisher","DOI":"10.1520\/JFS2003250"},{"key":"CIT0398","unstructured":"Yant WP, Schrenk HH, Patty FA. 1932. Toxicity of Dichlorotetrafluoroethane. U.S. Bureau of Mines: Washington, DC. Rep. No. R.I. 3185."},{"key":"CIT0399","first-page":"281","volume-title":"Cardiovascular Toxicology","author":"Zakhari S","year":"1982"}],"container-title":["Critical Reviews in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10408444.2018.1504276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:57:55Z","timestamp":1775282275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10408444.2018.1504276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,14]]},"references-count":401,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,9,14]]}},"alternative-id":["10.1080\/10408444.2018.1504276"],"URL":"https:\/\/doi.org\/10.1080\/10408444.2018.1504276","relation":{},"ISSN":["1040-8444","1547-6898"],"issn-type":[{"value":"1040-8444","type":"print"},{"value":"1547-6898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,14]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itxc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itxc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}