{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T11:56:54Z","timestamp":1794484614107,"version":"4.9.1"},"reference-count":189,"publisher":"Informa UK Limited","issue":"9","license":[{"start":{"date-parts":[[2018,10,21]],"date-time":"2018-10-21T00:00:00Z","timestamp":1540080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Beiersdorf AG"},{"DOI":"10.13039\/501100006475","name":"Bergen Research Foundation","doi-asserted-by":"crossref","award":["BFS2017TMT01"],"award-info":[{"award-number":["BFS2017TMT01"]}],"id":[{"id":"10.13039\/501100006475","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Toxicology"],"published-print":{"date-parts":[[2018,10,21]]},"DOI":"10.1080\/10408444.2018.1528207","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T11:20:33Z","timestamp":1543490433000},"page":"738-760","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":62,"title":["Computational approaches for skin sensitization prediction"],"prefix":"10.1080","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2891-1407","authenticated-orcid":false,"given":"Anke","family":"Wilm","sequence":"first","affiliation":[{"name":"Center for Bioinformatics, Universit\u00e4t Hamburg, Hamburg, Germany;"},{"name":"HITeC e.V, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8421-9381","authenticated-orcid":false,"given":"Jochen","family":"K\u00fchnl","sequence":"additional","affiliation":[{"name":"Front End Innovation, Beiersdorf AG, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-5877","authenticated-orcid":false,"given":"Johannes","family":"Kirchmair","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, Universit\u00e4t Hamburg, Hamburg, Germany;"},{"name":"Department of Chemistry, University of Bergen, Bergen, Norway;"},{"name":"Computational Biology Unit (CBU), University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-011-0693-2"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.7b04220"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1039\/C6GC01836J"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00124"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1039\/C6GC01492E"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.12.013"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.12.014"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/424203"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000304"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1021\/tx0601004"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2016.07.014"},{"key":"CIT0012","unstructured":"ATSDR. 2018. Substance priority list. [accessed 2018 Aug 14]. https:\/\/www.atsdr.cdc.gov\/SPL\/."},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/0887-2333(94)90081-7"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000003"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.14573\/altex.2012.1.003"},{"key":"CIT0016","unstructured":"Benfenati E, Manganaro A, Gini G. 2013. VEGA-QSAR: AI inside a platform for predictive toxicology. In: Baldoni M, Chesani F, Mello P, Montali M, editors. 2013. Proceedings of the workshop \"Popularize Artificial Intelligence 2013\"; December 5 2013; Turin, Italy. CEUR Workshop Proceedings Vol 1107."},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2016.04.003"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.05.008"},{"key":"CIT0019","unstructured":"BIOVIA. QSAR, ADMET and predictive toxicology. [accessed 2018 Aug 22]. http:\/\/accelrys.com\/products\/collaborative-science\/biovia-discovery-studio\/qsar-admet-and-predictive-toxicology.html."},{"key":"CIT0020","unstructured":"BIOVIA. 2017a. BIOVIA toxicity prediction model \u2013 skin sensitiser vs non sensitiser. (Q)SAR Model Reporting Format Database. [accessed 2018 Jan 16]. https:\/\/qsardb.jrc.ec.europa.eu\/qmrf\/protocol\/Q17-46-0042\/document?media=application%2Fpdf."},{"key":"CIT0021","unstructured":"BIOVIA. 2017b. BIOVIA toxicity prediction model \u2013 weak vs strong sensitiser. (Q)SAR Model Reporting Format Database. [accessed 2018 Jan 16]. https:\/\/qsardb.jrc.ec.europa.eu\/qmrf\/protocol\/Q17-46-0043\/document?media=application%2Fpdf."},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.7b00194"},{"key":"CIT0023","unstructured":"CAESAR. CAESAR project. [accessed 2018 Feb 6]. http:\/\/www.caesar-project.eu."},{"key":"CIT0024","unstructured":"CAESAR. Skin sensitization model. [accessed 2018 Jan 25]. http:\/\/www.caesar-project.eu\/index.php?page=results&section=endpoint&ne=2."},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3448"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-017-2097-4"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1021\/ci300111r"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1186\/1752-153X-4-S1-S5"},{"key":"CIT0029","unstructured":"Chembench. Accelerating chemical genomics research. [accessed 2018 July 25]. https:\/\/chembench.mml.unc.edu\/mudra\/."},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1021\/jm4004285"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2018.03.015"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/839682"},{"key":"CIT0033","unstructured":"CORAL. Free software for QSAR and nanoQSAR. [accessed 2018 Aug 13]. www.insilico.eu\/coral."},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2015.02.012"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2016.01.007"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.5b00197"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1080\/10915810591000631"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2016.04.008"},{"key":"CIT0039","unstructured":"ECHA. Homepage. [accessed 2018 July 17]. https:\/\/echa.europa.eu\/en."},{"key":"CIT0040","unstructured":"ECHA. 2017. The use of alternatives to testing on animals for the REACH Regulation. [accessed 2018 Aug 27]. https:\/\/echa.europa.eu\/documents\/10162\/13639\/alternatives_test_animals_2017_en.pdf."},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1002\/minf.200900006"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1021\/tx700322g"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2011.598141"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1080\/10629360802348985"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1021\/tx4000655"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(97)87277-8"},{"key":"CIT0047","unstructured":"EURL ECVAM. KeratinoSens assay for the testing of skin sensitizers [accessed 2018 Aug 29]. https:\/\/tsar.jrc.ec.europa.eu\/test-method\/tm2010-03."},{"key":"CIT0188","unstructured":"EUR-Lex. 2009. Regulation (EC) No 1223\/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products. [accessed 2018 Jul 4]. https:\/\/eur-lex.europa.eu\/eli\/reg\/2009\/1223\/oj."},{"key":"CIT0048","unstructured":"EURL ECVAM. LuSens assay. [accessed 2018 Mar 28]. https:\/\/tsar.jrc.ec.europa.eu\/test-method\/tm2011-10."},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1842-4"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1080\/1062936X.2017.1311941"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3348"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3354"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1080\/1062936X.2018.1455223"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2004.04034.x"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2005.05040"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1177\/026119290403200505"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.2174\/138161212799436359"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2012.02.007"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2018.03.006"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2017.08.005"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1002\/qsar.19960150307"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.14573\/altex.2013.3.275"},{"key":"CIT0189","doi-asserted-by":"publisher","DOI":"10.14573\/altex.1703291"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1021\/ci900471e"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr174"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12943"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3558"},{"key":"CIT0067","first-page":"379","volume":"32","author":"Hoffmann S","year":"2015","journal-title":"ALTEX"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2018.1429385"},{"key":"CIT0069","unstructured":"ICCVAM. 2011. Test method evaluation report: usefulness and Limitations of the Murine Local Lymph Node Assay for potency categorization of chemicals causing allergic contact dermatitis in humans. [accessed 2018 Apr 16]. https:\/\/ntp.niehs.nih.gov\/iccvam\/docs\/immunotox_docs\/llna-pot\/tmer.pdf."},{"key":"CIT0070","unstructured":"ICCVAM. 2013. NICEATM Murine Local Lymph Node Assay (LLNA) Database. [accessed 2017 Nov 24]. https:\/\/ntp.niehs.nih.gov\/pubhealth\/evalatm\/test-method-evaluations\/immunotoxicity\/nonanimal\/index.html#NICEATM-Murine-Local-Lymph-Node-Assay-LLNA-Database."},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics3020016"},{"key":"CIT0072","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/jat.2869","volume":"33","author":"Jaworska J","year":"2013","journal-title":"J Appl Toxicol"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.14573\/altex.2011.3.211"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1634-2"},{"key":"CIT0075","first-page":"515","volume":"34","author":"Johansson H","year":"2017","journal-title":"ALTEX"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2012.05.019"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfx115"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12199"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-399"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu046"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1021\/tx7002239"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1021\/jm040835a"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2009.09038"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq346"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2016.11.020"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2018.1429386"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1002\/qsar.19920110208"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.5b00392"},{"key":"CIT0089","unstructured":"LabMol. Pred-Skin 2.0. [accessed 2018 Aug 22]. http:\/\/labmol.com.br\/predskin\/."},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00969.x"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1177\/026119291604400309"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.14573\/altex.1606271"},{"key":"CIT0093","unstructured":"Lhasa Limited. Derek Nexus. [accessed 2018 Jan 26]. https:\/\/www.lhasalimited.org\/products\/derek-nexus.htm."},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3172"},{"key":"CIT0095","first-page":"135","volume":"33","author":"Luechtefeld T","year":"2016","journal-title":"ALTEX"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfy152"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1039\/C8TX00051D"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-011-9472-7"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2004.04032.x"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2016.01.009"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02652.x"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-012-0867-6"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1080\/1062936X.2012.679689"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043452596"},{"key":"CIT0105","unstructured":"MultiCASE. CASE Ultra: QSAR expert system. [accessed 2018 Aug 22]. http:\/\/www.multicase.com\/case-ultra."},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.10.194"},{"key":"CIT0107","unstructured":"Naive Bayes Skin Sensitization Model v. 1.1. [accessed 2018 Aug 16]. https:\/\/figshare.com\/articles\/Naive_Bayes_Skin_Sensitization_Model\/5758644."},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu229"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfy135"},{"key":"CIT0110","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/jat.2868","volume":"33","author":"Natsch A","year":"2013","journal-title":"J Appl Toxicol"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2013.05.007"},{"key":"CIT0112","unstructured":"OASIS-LMC. TIMES model for skin sensitization prediction. [accessed 2018 Jan 30]. http:\/\/oasis-lmc.org\/products\/models\/human-health-endpoints\/skin-sensitization.aspx."},{"key":"CIT0113","unstructured":"OASIS-LMC. TIMES-SS Software. [accessed 2018 Jan 30]. http:\/\/oasis-lmc.org\/products\/software\/times.aspx."},{"key":"CIT0114","unstructured":"OCHEM. Online chemical modeling environment. [accessed 2018 Mar 28]. https:\/\/ochem.eu\/home\/show.do."},{"key":"CIT0115","unstructured":"OECD. eChemPortal. [accessed 2018 July 17]. https:\/\/www.echemportal.org\/."},{"key":"CIT0116","unstructured":"OECD. The OECD QSAR Toolbox. [accessed 2018 July 4]. http:\/\/www.oecd.org\/chemicalsafety\/risk-assessment\/oecd-qsar-toolbox.htm."},{"key":"CIT0117","unstructured":"OECD. 2012. The adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins. [accessed 2018 Apr 17]. http:\/\/www.oecd.org\/env\/the-adverse-outcome-pathway-for-skin-sensitisation-initiated-by-covalent-binding-to-proteins-9789264221444-en.htm."},{"key":"CIT0118","unstructured":"OECD. 2014a. OECD series on testing and assessment. Guidance on grouping of chemicals, second edition. [accessed 2018 Apr 17]. https:\/\/www.oecd-ilibrary.org\/environment\/guidance-on-grouping-of-chemicals-second-edition_9789264274679-en."},{"key":"CIT0119","unstructured":"OECD. 2014b. OECD series on testing and assessment. Guidance document on the validation of (quantitative) structure-activity relationship [(Q)SAR] models. [accessed 2018 Apr 17]. http:\/\/www.oecd.org\/env\/guidance-document-on-the-validation-of-quantitative-structure-activity-relationship-q-sar-models-9789264085442-en.htm."},{"key":"CIT0120","unstructured":"OECD. 2015a. Test No. 442C: In chemico skin sensitisation. [accessed 2018 Apr 17] http:\/\/www.oecd.org\/env\/test-no-442c-in-chemico-skin-sensitisation-9789264229709-en.htm."},{"key":"CIT0121","unstructured":"OECD. 2015b. Test No. 442D: In vitro skin sensitisation. [accessed 2018 Apr 17]. http:\/\/www.oecd.org\/env\/test-no-442d-in-vitro-skin-sensitisation-9789264229822-en.htm."},{"key":"CIT0122","unstructured":"OECD. 2017a. Test No. 442E: In vitro skin sensitisation. [accessed 2018 Apr 17]. http:\/\/www.oecd.org\/env\/test-no-442e-in-vitro-skin-sensitisation-9789264264359-en.htm."},{"key":"CIT0123","unstructured":"OECD. 2017b. Guidance document on the reporting of defined approaches and individual information sources to be used within integrated approaches to testing and assessment (IATA) for skin sensitisation. [accessed 2018 July 4]. https:\/\/www.oecd-ilibrary.org\/docserver\/9789264274822-en.pdf."},{"key":"CIT0124","unstructured":"OECD. 2017c. Guidance document on the reporting of defined approaches to be used within integrated approaches to testing and assessment. [accessed 2018 July 4]. https:\/\/www.oecd-ilibrary.org\/docserver\/9789264274822-en.pdf."},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2017.06.002"},{"key":"CIT0126","doi-asserted-by":"publisher","DOI":"10.1186\/2050-6511-15-76"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1002\/qsar.200710067"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2013.06.002"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2016.08.007"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2007.03.003"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1016\/j.comtox.2017.05.003"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2014.06.001"},{"key":"CIT0133","doi-asserted-by":"publisher","DOI":"10.1080\/1062936X.2014.900520"},{"key":"CIT0134","unstructured":"Patlewicz G, Worth A. 2008. Review of Data Sources, QSARs and Integrated Testing Strategies for Skin Sensitisation. [accessed 2018 June 17]. https:\/\/eurl-ecvam.jrc.ec.europa.eu\/laboratories-research\/predictive_toxicology\/doc\/EUR_23225_EN.pdf."},{"key":"CIT0135","doi-asserted-by":"publisher","DOI":"10.1021\/ci00017a019"},{"key":"CIT0136","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2007.11.004"},{"key":"CIT0137","doi-asserted-by":"publisher","DOI":"10.1021\/tx400323e"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2011.00033"},{"key":"CIT0139","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2014.10.018"},{"key":"CIT0140","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2010.09.016"},{"key":"CIT0141","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12057"},{"key":"CIT0142","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.6b00241"},{"key":"CIT0143","doi-asserted-by":"publisher","DOI":"10.1021\/tx400355n"},{"key":"CIT0144","doi-asserted-by":"publisher","DOI":"10.1021\/tx060121y"},{"key":"CIT0145","doi-asserted-by":"publisher","DOI":"10.1021\/tx100420w"},{"key":"CIT0146","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02160.x"},{"key":"CIT0147","doi-asserted-by":"publisher","DOI":"10.1021\/tx800431x"},{"key":"CIT0148","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3479"},{"key":"CIT0149","doi-asserted-by":"publisher","DOI":"10.1021\/tx700169w"},{"key":"CIT0150","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.7b00050"},{"key":"CIT0151","doi-asserted-by":"publisher","DOI":"10.1016\/0022-5193(82)90199-0"},{"key":"CIT0152","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2013.06.003"},{"key":"CIT0153","doi-asserted-by":"publisher","DOI":"10.14573\/altex.1411011"},{"key":"CIT0154","volume-title":"The principles of humane experimental technique","author":"Russell WMS","year":"1959"},{"key":"CIT0155","doi-asserted-by":"publisher","DOI":"10.1002\/minf.201200081"},{"key":"CIT0156","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1919"},{"key":"CIT0157","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2015.05.016"},{"key":"CIT0158","unstructured":"SkinSensDB. [accessed 2018 Mar 29]. http:\/\/cwtung.kmu.edu.tw\/skinsensdb\/."},{"key":"CIT0159","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics3020014"},{"key":"CIT0160","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3366"},{"key":"CIT0161","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-011-9440-2"},{"key":"CIT0162","doi-asserted-by":"publisher","DOI":"10.1021\/ci300245q"},{"key":"CIT0163","unstructured":"Talete S.r.l. Dragon. [accessed 2018 Apr 16]. http:\/\/www.talete.mi.it\/products\/dragon_description.htm."},{"key":"CIT0164","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2013.09.007"},{"key":"CIT0165","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02004_2.x"},{"key":"CIT0166","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01220.x"},{"key":"CIT0167","doi-asserted-by":"publisher","DOI":"10.1002\/9783527628766"},{"key":"CIT0168","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.03.023"},{"key":"CIT0169","unstructured":"ToxFix. CADRE-SS skin sensitization model. [accessed 2018 Jan 30]. http:\/\/toxfix.com\/skin-sensitization.php."},{"key":"CIT0170","unstructured":"Toxtree. [accessed 2018 Apr 16]. http:\/\/toxtree.sourceforge.net\/."},{"key":"CIT0171","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2018.02.014"},{"key":"CIT0172","unstructured":"UL. REACHAcrossTM\u2013 satisfy REACH regulations and ECHA submissions with automated read-across. [accessed 2018 July 7]. https:\/\/www.ulreachacross.com\/index.html."},{"key":"CIT0173","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.6b00055"},{"key":"CIT0174","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2016.04.005"},{"key":"CIT0175","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2014.12.008"},{"key":"CIT0176","unstructured":"U.S. EPA. 2018 Interim science policy: Use of alternative approaches for skin sensitization as a replacement for laboratory animal testing. [accessed 2018 Aug 30]. https:\/\/www.regulations.gov\/document?D=EPA-HQ-OPP-2016-0093-0090."},{"key":"CIT0177","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2014.04.018"},{"key":"CIT0178","unstructured":"VEGA HUB. VEGA. [accessed 2018 Mar 28]. https:\/\/www.vegahub.eu\/portfolio-item\/vega-qsar\/."},{"key":"CIT0179","doi-asserted-by":"publisher","DOI":"10.1080\/1062936X.2017.1278617"},{"key":"CIT0180","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-017-0194-2"},{"key":"CIT0181","first-page":"429","volume":"20","author":"Warne MA","year":"2009","journal-title":"Environ Res"},{"key":"CIT0182","doi-asserted-by":"publisher","DOI":"10.1089\/aivt.2017.0040"},{"key":"CIT0183","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2016.01.008"},{"key":"CIT0184","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2015.05.026"},{"key":"CIT0185","doi-asserted-by":"publisher","DOI":"10.1021\/jz100247x"},{"key":"CIT0186","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10073237"},{"key":"CIT0187","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3424"}],"container-title":["Critical Reviews in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tandfonline.com\/doi\/pdf\/10.1080\/10408444.2018.1528207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10408444.2018.1528207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T21:52:01Z","timestamp":1720821121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10408444.2018.1528207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,21]]},"references-count":189,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,10,21]]}},"alternative-id":["10.1080\/10408444.2018.1528207"],"URL":"https:\/\/doi.org\/10.1080\/10408444.2018.1528207","relation":{},"ISSN":["1040-8444","1547-6898"],"issn-type":[{"value":"1040-8444","type":"print"},{"value":"1547-6898","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,21]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itxc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itxc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}