{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T09:47:37Z","timestamp":1794649657912,"version":"4.9.1"},"reference-count":258,"publisher":"Informa UK Limited","issue":"4-6","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010438","name":"Francis Crick Institute","doi-asserted-by":"publisher","award":["cc2098"],"award-info":[{"award-number":["cc2098"]}],"id":[{"id":"10.13039\/100010438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Critical Reviews in Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2025,11,2]]},"DOI":"10.1080\/10409238.2025.2564068","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:31:38Z","timestamp":1759336298000},"page":"200-230","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":12,"title":["From serendipity to strategy: molecular glue degraders in cancer therapeutics"],"prefix":"10.1080","volume":"60","author":[{"given":"Sarah","family":"Darling","sequence":"first","affiliation":[{"name":"DNA Recombination and Repair, The Francis Crick Institute","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilirjana","family":"Bajrami","sequence":"additional","affiliation":[{"name":"DNA Recombination and Repair, The Francis Crick Institute","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8848-9418","authenticated-orcid":false,"given":"Stephen C.","family":"West","sequence":"additional","affiliation":[{"name":"DNA Recombination and Repair, The Francis Crick Institute","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,10]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.44582"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr050361j"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05175"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-125682"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0366-7"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200792"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2545-9"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10122683"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v98.2.492"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00371-6"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.slasd.2024.100162"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13931"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-02050-4"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023019637"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.66"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83622-1"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2023.02.005"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01973261"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128x(89)90076-7"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005607"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.12.5381"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/369756a0"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0411-6"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-015-9702-0"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25719"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.4c00799"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.12.002"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-1819-y"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2874"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00035-07"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.14.5801-5811.2005"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202500169"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05408-1"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1770109"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031103"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-2437"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.9.4082"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.632399"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1087"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1887"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.e17054"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109394"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2cs00197g"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.12.025"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2019.10.005"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-113191"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.08.013"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69780-8"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00570"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2016.06.002"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256337"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2021.02.009"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-450114"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13527"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00923.x"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.186601"},{"issue":"4","key":"e_1_3_2_58_1","first-page":"334","article-title":"Eukaryotic polypeptide chain release factor eRF3 is an eRF1- and ribosome-dependent guanosine triphosphatase","volume":"2","author":"Frolova L","year":"1996","unstructured":"Frolova L, Le Goff X, Zhouravleva G, Davydova E, Philippe PM, Kisselev L. 1996. Eukaryotic polypeptide chain release factor eRF3 is an eRF1- and ribosome-dependent guanosine triphosphatase. RNA. 2(4):334\u2013341.","journal-title":"RNA"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2022.100994"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1010608317361"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12708"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02415"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1439790"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2024.102825"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.1c00118"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007081"},{"issue":"18","key":"e_1_3_2_67_1","first-page":"5183","article-title":"Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration","volume":"48","author":"Gottardis MM","year":"1988","unstructured":"Gottardis MM, Jordan VC. 1988. Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration. Cancer Res. 48(18):5183\u20135187.","journal-title":"Cancer Res"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36107"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.336"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01444"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/14796694.2024.2377530"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal3755"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-120122-081037"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128342"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.03.001"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00504"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04947-6"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16959"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.11.001"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13866"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01754-x"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07089-6"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.052647"},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00881-07"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05333-5"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116848"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.slasd.2024.100197"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade3168"},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1177319"},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10693"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131033"},{"key":"e_1_3_2_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2021.04.002"},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-018-0236-z"},{"key":"e_1_3_2_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.162"},{"key":"e_1_3_2_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2011.03.006"},{"key":"e_1_3_2_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.32"},{"key":"e_1_3_2_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005116"},{"key":"e_1_3_2_99_1","doi-asserted-by":"publisher","DOI":"10.1177\/2472555221991104"},{"key":"e_1_3_2_100_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090331"},{"key":"e_1_3_2_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.081"},{"key":"e_1_3_2_102_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02251"},{"key":"e_1_3_2_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb02928.x"},{"key":"e_1_3_2_104_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0616"},{"key":"e_1_3_2_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(00)80034-5"},{"key":"e_1_3_2_106_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4368"},{"key":"e_1_3_2_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602164"},{"key":"e_1_3_2_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd6263"},{"key":"e_1_3_2_109_1","doi-asserted-by":"publisher","DOI":"10.1159\/000531452"},{"key":"e_1_3_2_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2024.04.002"},{"key":"e_1_3_2_111_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-698092"},{"key":"e_1_3_2_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-023-01409-z"},{"key":"e_1_3_2_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14610"},{"key":"e_1_3_2_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244851"},{"key":"e_1_3_2_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52871-9"},{"key":"e_1_3_2_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2025.03.006"},{"key":"e_1_3_2_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.190"},{"key":"e_1_3_2_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21610"},{"key":"e_1_3_2_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0541-0"},{"key":"e_1_3_2_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.03.022"},{"key":"e_1_3_2_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.07.003"},{"key":"e_1_3_2_122_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2024.2306845"},{"key":"e_1_3_2_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2020.06.013"},{"key":"e_1_3_2_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.03.020"},{"key":"e_1_3_2_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-024-01668-4"},{"key":"e_1_3_2_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05779-1"},{"key":"e_1_3_2_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1722-1"},{"key":"e_1_3_2_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105505"},{"key":"e_1_3_2_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199909)29:09<2651::AID-IMMU2651>3.0.CO;2-L"},{"key":"e_1_3_2_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16132436"},{"key":"e_1_3_2_131_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061292"},{"key":"e_1_3_2_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90124-h"},{"key":"e_1_3_2_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101015"},{"key":"e_1_3_2_134_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.277236"},{"key":"e_1_3_2_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42233-2"},{"key":"e_1_3_2_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103756"},{"key":"e_1_3_2_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.119"},{"key":"e_1_3_2_138_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244917"},{"key":"e_1_3_2_139_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59994"},{"key":"e_1_3_2_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2016.44"},{"key":"e_1_3_2_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2016.06.007"},{"key":"e_1_3_2_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.03.108"},{"key":"e_1_3_2_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126308"},{"key":"e_1_3_2_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.09.002"},{"key":"e_1_3_2_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-023-01458-4"},{"key":"e_1_3_2_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18611"},{"key":"e_1_3_2_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0129-x"},{"key":"e_1_3_2_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-0594-x"},{"key":"e_1_3_2_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)90927-8"},{"key":"e_1_3_2_150_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.8b00698"},{"key":"e_1_3_2_151_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.28156"},{"key":"e_1_3_2_152_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v99.12.4525"},{"key":"e_1_3_2_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12755"},{"key":"e_1_3_2_154_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.8.2004"},{"key":"e_1_3_2_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3257"},{"key":"e_1_3_2_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.12.020"},{"key":"e_1_3_2_157_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604765113"},{"key":"e_1_3_2_158_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.1858"},{"key":"e_1_3_2_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.597"},{"key":"e_1_3_2_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.02.027"},{"key":"e_1_3_2_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2024.06.004"},{"key":"e_1_3_2_162_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1308539"},{"key":"e_1_3_2_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28907-3"},{"key":"e_1_3_2_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44698-1"},{"key":"e_1_3_2_165_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.20.7572-7582.2000"},{"key":"e_1_3_2_166_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01867-08"},{"key":"e_1_3_2_167_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026336"},{"key":"e_1_3_2_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601629"},{"key":"e_1_3_2_169_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm9902638"},{"key":"e_1_3_2_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.07.004"},{"key":"e_1_3_2_171_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516192"},{"key":"e_1_3_2_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.10.016"},{"key":"e_1_3_2_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.010"},{"key":"e_1_3_2_174_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adt6736"},{"key":"e_1_3_2_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16979"},{"key":"e_1_3_2_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.09.004"},{"key":"e_1_3_2_177_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c06127"},{"key":"e_1_3_2_178_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620711413165"},{"key":"e_1_3_2_179_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4019-0"},{"key":"e_1_3_2_180_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.1136"},{"key":"e_1_3_2_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2823"},{"key":"e_1_3_2_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2024.04.001"},{"key":"e_1_3_2_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90570-3"},{"key":"e_1_3_2_184_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.141230798"},{"key":"e_1_3_2_185_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.17.7769-7778.2004"},{"key":"e_1_3_2_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.162"},{"key":"e_1_3_2_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.031"},{"key":"e_1_3_2_188_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1165409"},{"key":"e_1_3_2_189_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.139.6.1797"},{"key":"e_1_3_2_190_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.27506"},{"key":"e_1_3_2_191_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1877"},{"key":"e_1_3_2_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.07.114"},{"key":"e_1_3_2_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.08.001"},{"key":"e_1_3_2_194_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1702904"},{"key":"e_1_3_2_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90158-9"},{"key":"e_1_3_2_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.12.020"},{"key":"e_1_3_2_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90111-J"},{"key":"e_1_3_2_198_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-337303"},{"key":"e_1_3_2_199_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07064"},{"key":"e_1_3_2_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1295-z"},{"key":"e_1_3_2_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.017"},{"key":"e_1_3_2_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3333"},{"key":"e_1_3_2_203_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2006560117"},{"key":"e_1_3_2_204_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15194816"},{"key":"e_1_3_2_205_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat0572"},{"key":"e_1_3_2_206_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-012-0088-2"},{"key":"e_1_3_2_207_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09358-9"},{"key":"e_1_3_2_208_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911183412102"},{"key":"e_1_3_2_209_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2374-x"},{"key":"e_1_3_2_210_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2925-1"},{"key":"e_1_3_2_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(62)91943-8"},{"key":"e_1_3_2_212_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702541200"},{"key":"e_1_3_2_213_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005827"},{"key":"e_1_3_2_214_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008676"},{"key":"e_1_3_2_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2025.06.005"},{"key":"e_1_3_2_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.09.009"},{"key":"e_1_3_2_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05731"},{"key":"e_1_3_2_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110712"},{"key":"e_1_3_2_219_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01832"},{"key":"e_1_3_2_220_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adk6129"},{"key":"e_1_3_2_221_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.218289"},{"key":"e_1_3_2_222_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2822"},{"key":"e_1_3_2_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.06.028"},{"key":"e_1_3_2_224_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00729-9"},{"key":"e_1_3_2_225_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-025-01936-x"},{"key":"e_1_3_2_226_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2363"},{"key":"e_1_3_2_227_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"e_1_3_2_228_1","doi-asserted-by":"publisher","DOI":"10.1002\/cm.10040"},{"key":"e_1_3_2_229_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21096"},{"key":"e_1_3_2_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(88)90086-6"},{"issue":"15","key":"e_1_3_2_231_1","first-page":"3867","article-title":"A potent specific pure antiestrogen with clinical potential","volume":"51","author":"Wakeling AE","year":"1991","unstructured":"Wakeling AE, Dukes M, Bowler J. 1991. A potent specific pure antiestrogen with clinical potential. Cancer Res. 51(15):3867\u20133873.","journal-title":"Cancer Res"},{"key":"e_1_3_2_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.01.010"},{"key":"e_1_3_2_233_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00802-w"},{"key":"e_1_3_2_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(00)80637-8"},{"key":"e_1_3_2_235_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.4569"},{"key":"e_1_3_2_236_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01647-6"},{"key":"e_1_3_2_237_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070596"},{"key":"e_1_3_2_238_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811267106"},{"key":"e_1_3_2_239_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-594507"},{"key":"e_1_3_2_240_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01576"},{"key":"e_1_3_2_241_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.3.270"},{"key":"e_1_3_2_242_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab1433"},{"key":"e_1_3_2_243_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014701"},{"key":"e_1_3_2_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.04.014"},{"key":"e_1_3_2_245_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.707295"},{"key":"e_1_3_2_246_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01589-z"},{"key":"e_1_3_2_247_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08533-3"},{"key":"e_1_3_2_248_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00598-7"},{"key":"e_1_3_2_249_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020105375"},{"key":"e_1_3_2_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.05.024"},{"key":"e_1_3_2_251_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08532-4"},{"key":"e_1_3_2_252_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.10.069"},{"key":"e_1_3_2_253_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00589"},{"key":"e_1_3_2_254_1","doi-asserted-by":"crossref","unstructured":"Zandi TA et al. 2024. Discovery of molecular glues that bind FKBP12 and novel targets using DNAbarcoded libraries. bioRxiv. 2024.2012.2009.627499. https:\/\/www.biorxiv.org\/content\/10.1101\/2024.12.09.627499v2","DOI":"10.1101\/2024.12.09.627499"},{"key":"e_1_3_2_255_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.11.045"},{"key":"e_1_3_2_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102515"},{"key":"e_1_3_2_257_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02004-x"},{"key":"e_1_3_2_258_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-356063"},{"key":"e_1_3_2_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2010.08.010"}],"container-title":["Critical Reviews in Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10409238.2025.2564068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T10:03:13Z","timestamp":1763805793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10409238.2025.2564068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":258,"journal-issue":{"issue":"4-6","published-print":{"date-parts":[[2025,11,2]]}},"alternative-id":["10.1080\/10409238.2025.2564068"],"URL":"https:\/\/doi.org\/10.1080\/10409238.2025.2564068","relation":{},"ISSN":["1040-9238","1549-7798"],"issn-type":[{"value":"1040-9238","type":"print"},{"value":"1549-7798","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ibmg20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ibmg20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}