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Age, sex and breed distribution; results of a necropsic survey. Bibl Haematol"},{"key":"CIT0155","first-page":"909","volume":"72","author":"Onions DE","year":"1984","journal-title":"J Natl Cancer Inst"},{"key":"CIT0156","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1994.9694435"},{"key":"CIT0158","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1994.9694451"},{"key":"CIT0159","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.7.544"},{"key":"CIT0160","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1981.25"},{"key":"CIT0161","first-page":"1","volume":"10","author":"Hardell L","year":"1998","journal-title":"Oncol Res"},{"key":"CIT0162","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/83.17.1226"},{"key":"CIT0164","first-page":"233","volume":"3","author":"Reynolds PM","year":"1994","journal-title":"Cancer Epidemiol Biomark Prevent"},{"key":"CIT0165","doi-asserted-by":"publisher","DOI":"10.1177\/030098589403100504"},{"key":"CIT0166","first-page":"187","volume":"11","author":"Owen LN","year":"1975","journal-title":"Cell-mediated and humoral immunity in dogs with spontaneous lymphosarco-ma. 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