{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:22:11Z","timestamp":1772770931018,"version":"3.50.1"},"reference-count":50,"publisher":"Informa UK Limited","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia &amp; Lymphoma"],"published-print":{"date-parts":[[2006,1,1]]},"DOI":"10.1080\/10428190600942769","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T20:31:05Z","timestamp":1160166665000},"page":"2488-2504","source":"Crossref","is-referenced-by-count":39,"title":["Very high-dose methotrexate (33.6 g\/m<sup>2<\/sup>) as central nervous system preventive therapy for childhood acute lymphoblastic leukemia: results of National Cancer Institute\/Children's Cancer Group trials CCG-191P, CCG-134P and CCG-144P"],"prefix":"10.1080","volume":"47","author":[{"given":"Paul C.","family":"Nathan","sequence":"first","affiliation":[{"name":"Pediatric Oncology Branch"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trish","family":"Whitcomb","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela L.","family":"Wolters","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch"},{"name":"Medical Illness Counseling Center, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth M.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Biostatistics and Data Management Section and HIV & AIDS Malignancy Branch18, Center for Cancer Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Clinical D","given":"Frank M.","family":"Balis","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pim","family":"Brouwers","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Hunsberger","sequence":"additional","affiliation":[{"name":"Biostatistics Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Feusner","sequence":"additional","affiliation":[{"name":"Children's Hospital of Northern California, Oakland, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harland","family":"Sather","sequence":"additional","affiliation":[{"name":"Children's Oncology Group, Arcadia, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Miser","sequence":"additional","affiliation":[{"name":"Columbus Children's Hospital, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorrie F.","family":"Odom","sequence":"additional","affiliation":[{"name":"Denver Children's Hospital, Denver, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Poplack","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Reaman","sequence":"additional","affiliation":[{"name":"Children's National Medical Center, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Archie","family":"Bleyer","sequence":"additional","affiliation":[{"name":"Children's Regional Medical Center, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2009,7,1]]},"reference":[{"key":"CIT0001","volume-title":"SEER Cancer Statistics Review, 1975 \u2013 2000","author":"Ries L AG","year":"2003"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92997-1"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(02)00042-5"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)11079-6"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035091"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199809)59:1<91::AID-AJH18>3.0.CO;2-4"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91849-3"},{"key":"CIT0008","first-page":"131","volume":"12","author":"Bleyer W A","year":"1985","journal-title":"Semin Oncol"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050038"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197507242930402"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106181"},{"key":"CIT0012","first-page":"115","volume-title":"Clinical Pharmacology of Anti-Neoplastic Drugs","author":"Bleyer W A","year":"1978"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1985.3.1.19"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1985.3.4.485"},{"key":"CIT0015","volume-title":"McCarthy Scales of Children's Abilities","author":"McCarthy D","year":"1972"},{"key":"CIT0016","volume-title":"Wechsler Intelligence Scale for Children \u2013 Revised","author":"Wechsler D","year":"1974"},{"key":"CIT0017","volume-title":"Wechsler Adult Intelligence Scale","author":"Wechsler D","year":"1955"},{"key":"CIT0018","volume-title":"Wechsler Adult Intelligence Scale \u2013 Revised","author":"Wechsler D","year":"1981"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"CIT0020","first-page":"103","volume":"50","author":"Mantel N","year":"1966","journal-title":"Cancer Chemother Rep"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.2307\/2529876"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.1.18"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.3.920"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04738.x"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401939"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.08.047"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1080\/08880010390158810"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.7.1383"},{"key":"CIT0029","first-page":"1226","volume":"94","author":"Kamps W A","year":"1999","journal-title":"Blood"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.5.1211"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1616"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052603"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.096"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsi016"},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1542\/peds.75.4.745","volume":"75","author":"Copeland D R","year":"1985","journal-title":"Pediatrics"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.8.1348"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1984.2.12.1327"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-198806000-00002"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/7.6.481"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-199910000-00013"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.2.445"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4811-9_58"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198602203140803"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.10.1539"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.6.1115"},{"key":"CIT0046","first-page":"1641","volume":"42","author":"Keefe D A","year":"1982","journal-title":"Cancer Res"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1043878"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(87)90308-7"},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1200\/JCO.1995.13.10.2497","volume":"13","author":"Conter V","year":"1995","journal-title":"J Clin Oncol"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.3.520"}],"container-title":["Leukemia &amp; Lymphoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10428190600942769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T07:14:44Z","timestamp":1683616484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10428190600942769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,1]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,1,1]]}},"alternative-id":["10.1080\/10428190600942769"],"URL":"https:\/\/doi.org\/10.1080\/10428190600942769","relation":{},"ISSN":["1042-8194","1029-2403"],"issn-type":[{"value":"1042-8194","type":"print"},{"value":"1029-2403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,1]]}}}