{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:09:21Z","timestamp":1787738961149,"version":"build-2784847793"},"reference-count":51,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Leukemia &amp; Lymphoma"],"published-print":{"date-parts":[[2020,1,28]]},"DOI":"10.1080\/10428194.2019.1672052","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T11:43:12Z","timestamp":1571226192000},"page":"309-317","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":26,"title":["Phase 1 study of the Aurora kinase A inhibitor alisertib (MLN8237) combined with the histone deacetylase inhibitor vorinostat in lymphoid malignancies"],"prefix":"10.1080","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5292-8298","authenticated-orcid":false,"given":"Tanya","family":"Siddiqi","sequence":"first","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Frankel","sequence":"additional","affiliation":[{"name":"Department of Information Sciences, City of Hope National Medical Center, Duarte, CA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"Beumer","sequence":"additional","affiliation":[{"name":"Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA;"},{"name":"Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA;"},{"name":"Division of Hematology\/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian F.","family":"Kiesel","sequence":"additional","affiliation":[{"name":"Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA;"},{"name":"Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Christner","sequence":"additional","affiliation":[{"name":"Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Ruel","sequence":"additional","affiliation":[{"name":"Department of Information Sciences, City of Hope National Medical Center, Duarte, CA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3497-2513","authenticated-orcid":false,"given":"Joo Y.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Division of Hematology, University of Southern California, Los Angeles, CA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sikander","family":"Ailawadhi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Mayo Clinic, Jacksonville, FL, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kaesberg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology and Oncology, University of California-Davis Medical Center, Sacramento, CA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Popplewell","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-5193","authenticated-orcid":false,"given":"Sandrine","family":"Puverel","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Piekarz","sequence":"additional","affiliation":[{"name":"Cancer Therapy Evaluation Program, National Institutes of Health, National Cancer Institute, Bethesda, MD, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Forman","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-5909","authenticated-orcid":false,"given":"Edward M.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Division of Molecular Pharmacology, City of Hope, Duarte, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1405"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-06-0208"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1526"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0019"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1038\/2496"},{"issue":"4","key":"CIT0006","first-page":"1420","volume":"9","author":"Gritsko TM","year":"2003","journal-title":"Clin Cancer Res"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-5268"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.6.4.3817"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1650"},{"issue":"9","key":"CIT0010","first-page":"2041","volume":"59","author":"Tanaka T","year":"1999","journal-title":"Cancer Res"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2006.01974.x"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1080\/10428190410001683615"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-259523"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1536"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0571"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0589"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.06.040"},{"issue":"4","key":"CIT0018","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1470-2045(15)70051-3","volume":"16","author":"Melichar B","year":"2015","journal-title":"Lancet Oncol"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3251"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.6327"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.8793"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-013-0050-9"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.4889"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.158394"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30073"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.3027.3027"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-10-1247"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2016.1164140"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.1398"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.608448"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12819"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1038\/nrd772"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00165-X"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2259"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.11.049"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-012-9831-9"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-0033"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1918"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-007-0260-8"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.7.9.6415"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.04.044"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"issue":"15","key":"CIT0044","first-page":"3094","volume":"28","author":"Dees EC","year":"2010","journal-title":"J Clin Oncol"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V116.21.3273.3273"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-014-0121-6"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.14.167"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.410"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-015-0114-8"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00899"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.9679"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.220012"}],"container-title":["Leukemia &amp; Lymphoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10428194.2019.1672052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T11:57:47Z","timestamp":1584619067000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10428194.2019.1672052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,16]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,1,28]]}},"alternative-id":["10.1080\/10428194.2019.1672052"],"URL":"https:\/\/doi.org\/10.1080\/10428194.2019.1672052","relation":{},"ISSN":["1042-8194","1029-2403"],"issn-type":[{"value":"1042-8194","type":"print"},{"value":"1029-2403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,16]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ilal20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ilal20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-28","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}