{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:31:44Z","timestamp":1794004304117,"version":"4.8.0"},"reference-count":32,"publisher":"Informa UK Limited","issue":"5","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Leukemia & Lymphoma"],"published-print":{"date-parts":[[2021,4,16]]},"DOI":"10.1080\/10428194.2020.1861270","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T11:12:49Z","timestamp":1609153969000},"page":"1187-1194","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":14,"title":["Phase 1 study of belinostat (PXD-101) and bortezomib (Velcade, PS-341) in patients with relapsed or refractory acute leukemia and myelodysplastic syndrome"],"prefix":"10.1080","volume":"62","author":[{"given":"Beata","family":"Holkova","sequence":"first","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"},{"name":"Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Shafer","sequence":"additional","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"},{"name":"Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Yazbeck","sequence":"additional","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"},{"name":"Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Dave","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4343-5712","authenticated-orcid":false,"given":"Prithviraj","family":"Bose","sequence":"additional","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"},{"name":"Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Beth","family":"Tombes","sequence":"additional","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Shrader","sequence":"additional","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wan","sequence":"additional","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"},{"name":"Department of Statistics, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipankar","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"},{"name":"Department of Statistics, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caryn","family":"Weir","sequence":"additional","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth B.","family":"Collins","sequence":"additional","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Garnett","sequence":"additional","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Kmieciak","sequence":"additional","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"},{"name":"Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Garcia-Manero","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Grant","sequence":"additional","affiliation":[{"name":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"},{"name":"Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA"},{"name":"Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA"},{"name":"Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA"},{"name":"The Institute for Molecular Medicine, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4245"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-2977"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601081"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2911"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0508"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207170"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1195"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1015"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.02.001"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252462599"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2177"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-12-1039"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.13.5429-5444.2005"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0737"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0561"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.877134"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08591.x"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.036"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2876"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-3-294"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-285403"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70440-1"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V124.21.972.972"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2173"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1126\/science.1226344"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301689"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.7542"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2017.10.009"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2864"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1177\/2040620715592567"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30949"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2014.06.007"}],"container-title":["Leukemia & Lymphoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10428194.2020.1861270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T12:04:33Z","timestamp":1620475473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10428194.2020.1861270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,28]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,4,16]]}},"alternative-id":["10.1080\/10428194.2020.1861270"],"URL":"https:\/\/doi.org\/10.1080\/10428194.2020.1861270","relation":{},"ISSN":["1042-8194","1029-2403"],"issn-type":[{"value":"1042-8194","type":"print"},{"value":"1029-2403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,28]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ilal20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ilal20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}